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Cat. No.: HY-189368

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SDH-IN-49

SDH-IN-49 is a MoSDH inhibitor that inhibits SDH activity and disrupts the tricarboxylic acid cycle and respiratory chain electron transport. SDH-IN-49 exhibits antifungal activity against Magnaporthe oryzae (EC₅₀ of 2.56 μg/mL). SDH-IN-49 can be used in research related to plant pathogenic fungi, such as Magnaporthe oryzae.

For research use only. We do not sell to patients.

Formula: C₁₈H₁₀F₇NO
Molecular Weight:389.27

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SDH-IN-49 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

In Vitro

SDH-IN-49 (compound Kc1) (1-50 μg/mL; 3-6 days) exhibits potent and specific antifungal activity against Magnaporthe oryzae, with an EC₅₀ of 2.56 μg/mL^[1].
SDH-IN-49 inhibits Magnaporthe oryzae succinate dehydrogenase (MoSDH) activity, with inhibition rates of 45.76% and 73.20% at 2.5 and 5 μg/mL, respectively^[1].
SDH‑IN‑49 forms a complex with MoSDH that maintains a stable conformation throughout the entire 100 ns simulation, demonstrating strong binding affinity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Chemical Information

Molecular Weight 389.27
Formula C₁₈H₁₀F₇NO
SMILES

OC(C1=CC=C(F)C=C1)C2=CC(C(F)(F)F)=NC3=C(C(F)(F)F)C=CC=C32
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Qin LL, et al. Design and Synthesis of Potential Quinoline-Based SDH Inhibitors Inspired by Quinine Alkaloids with Activity against Phytopathogenic Fungi and Bacteria. Journal of agricultural and food chemistry. 2026 Aug 26;74(33):26759-26769.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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