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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
193 Results for "
APP
" in MedChemExpress (MCE) Product Catalog:
Products (193)
193 Results for "APP" in MCE Product Catalog:
Cat. No.: HY-176036A
Target:
Research Areas:
MS1262 TFA is a blood-brain barrier-permeable, selective inhibitor of histone methyltransferases G9a (EHMT2) and GLP (EHMT1), with an IC50 of 19 nM and a Kd of 74 nM against G9a, and an IC50 of 6 nM and a Kd of 19 nM against GLP. MS1262 TFA reduces the dimethylation level of histone H3 lysine 9 and decreases the size of Aβ plaques. MS1262 TFA restores hippocampal long-term potentiation (LTP) and miniature excitatory postsynaptic current (sEPSC) frequency, ameliorates spatial memory deficits, and reverses anxiety-like and depression-like behaviors in AD model mice. MS1262 TFA reverses the expression/phosphorylation levels of early AD biomarkers, providing support for stage-specific diagnosis of AD. MS1262 TFA reduces the risk of thrombus rupture. MS1262 TFA can be used in research related to Alzheimer's disease, colorectal cancer, and triple-negative breast cancer .
Cat. No.: HY-P990301
Target:
Research Areas:
Cat. No.: HY-P703772
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: XPNPEP2; X-Prolyl Aminopeptidase 2; Xaa-Pro Aminopeptidase 2; Membrane-Bound Aminopeptidase P; X-Prolyl Aminopeptidase (Aminopeptidase P) 2; Membrane-Bound; Aminoacylproline Aminopeptidase; X-Pro Aminopeptidase 2; Membrane-Bound APP; Membrane-Bound AmP;
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P7499
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: XPNPEP2; X-Prolyl Aminopeptidase 2; Xaa-Pro Aminopeptidase 2; Membrane-Bound Aminopeptidase P; X-Prolyl Aminopeptidase (Aminopeptidase P) 2; Membrane-Bound; Aminoacylproline Aminopeptidase; X-Pro Aminopeptidase 2; Membrane-Bound APP; Membrane-Bound AmP; MAmP; AEACE
Species:
Human
Source:
HEK293
Cat. No.: HY-P703785
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: XPNPEP2; X-Prolyl Aminopeptidase 2; Xaa-Pro Aminopeptidase 2; Membrane-Bound Aminopeptidase P; X-Prolyl Aminopeptidase (Aminopeptidase P) 2; Membrane-Bound; Aminoacylproline Aminopeptidase; X-Pro Aminopeptidase 2; Membrane-Bound APP; Membrane-Bound AmP; MAmP; AEACE
Species:
Rat
Source:
HEK293
Cat. No.: HY-P71435
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: XPNPEP3; X-Prolyl Aminopeptidase 3; APP3; NPHPL1; ICP55; X-Prolyl Aminopeptidase 3; Mitochondrial; Intermediate Cleaving Peptidase 55; Xaa-Pro Aminopeptidase 3; X-Pro Aminopeptidase 3; X-Prolyl Aminopeptidase (Aminopeptidase P) 3; Putative; Probable Xaa-Pro Amino
Species:
Human
Source:
E. coli
Cat. No.: HY-P82169
Synonyms: BACE1; BACE; KIAA1149; Beta-secretase 1; Aspartyl protease 2; ASP2; Asp 2; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; Memapsin-2; Membrane-associated aspartic protease 2
Cat. No.: HY-P85420
Synonyms: BACE1; BACE; KIAA1149; Beta-secretase 1; Aspartyl protease 2; ASP2; Asp 2; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; Memapsin-2; Membrane-associated aspartic protease 2
Cat. No.: HY-P86180
Synonyms: BACE1; BACE; KIAA1149; Beta-secretase 1; Aspartyl protease 2; ASP2; Asp 2; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; Memapsin-2; Membrane-associated aspartic protease 2
Cat. No.: HY-185724
Target:
Research Areas:
rG4 mut_AHPC_PEG2 is a structure-disruptive negative control PROTAC. rG4 mut_AHPC_PEG2 demonstrates that the RNA G-quadruplex conformation is an absolute prerequisite for the recruitment and degradation of DHX36 by retaining the E3-recruiting moiety (AHPC-PEG2) while disrupting the secondary structure of the nucleic acid moiety (mutated RNA G-quadruplex), .
Cat. No.: HY-P7498
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: XPNPEP1; X-Prolyl Aminopeptidase 1; XPNPEPL1; XPNPEPL; XPNPEP; Xaa-Pro Aminopeptidase 1; X-Prolyl Aminopeptidase (Aminopeptidase P) 1; Soluble; X-Prolyl Aminopeptidase 1; Soluble; Aminoacylproline Aminopeptidase; Cytosolic Aminopeptidase P; Soluble Aminopeptidase P; X-Pro Aminopeptidase 1; X-Prolyl Aminopeptidase (Aminopeptidase P)-Like; Aminopeptidase P; Cytosolic; APP1; SAMP; SAmp
Species:
Human
Source:
E. coli
Cat. No.: HY-P700260
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: XPNPEP1; X-Prolyl Aminopeptidase 1; XPNPEPL1; XPNPEPL; XPNPEP; Xaa-Pro Aminopeptidase 1; X-Prolyl Aminopeptidase (Aminopeptidase P) 1; Soluble; X-Prolyl Aminopeptidase 1; Soluble; Aminoacylproline Aminopeptidase; Cytosolic Aminopeptidase P; Soluble Aminopeptidase P; X-Pro Aminopeptidase 1; X-Prolyl Aminopeptidase (Aminopeptidase P)-Like; Aminopeptidase P; Cytosolic; APP1; SAMP; SAmp
Species:
Human
Source:
E. coli
Cat. No.: HY-P703601
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: UBA3; NEDD8-Activating Enzyme E1 Subunit 2; Prev. UBE1C; NEDD8-Activating Enzyme E1C; NEDD8-Activating Enzyme E1 Catalytic Subunit; UBA3, Ubiquitin-Activating Enzyme E1 Homolog; HUba3; Ubiquitin-Like Modifier Activating Enzyme 3; NAE2; Ubiquitin-Like Modifier-Activating Enzyme 3; Ubiquitin-Activating Enzyme E1C (Homologous To Yeast UBA3); Ubiquitin-Activating Enzyme E1C; Ubiquitin-Activating Enzyme E1C (UBA3 Homolog, Yeast); Nedd8-Activating Enzyme HUba3; Ubiquitin Like Modifier Activating Enzyme 3; Ubiquitin-Activating Enzyme 3; NAE1; Proto-Oncogene Protein 1; Prev. APPBP1; NEDD8-Activating Enzyme E1 Subunit; APP-BP1; Alternative Protein NAE1; Ula-1; Protooncogene Protein 1; Amyloid Beta Precursor Protein-Binding Protein 1, 59 KDa; A-116A10.1; Amyloid Beta Precursor Protein Binding Protein 1, 59kDa; NEDFIH; NEDD8-Activating Enzyme E1 Regulatory Subunit; HPP1; Amyloid Protein-Binding Protein 1; NEDD8 Activating Enzyme E1 Subunit 1; Amyloid Beta Precursor Protein-Binding Protein 1, 59kD
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
