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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
284 Results for "
protons
" in MedChemExpress (MCE) Product Catalog:
Products (284)
284 Results for "protons" in MCE Product Catalog:
Cat. No.: HY-115312
CAS No.: 101387-98-8
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Ro 18-5364 is an inhibitor of gastric H+/K+ ATPase, which has the effect of inhibiting the activity of the enzyme. Ro 18-5364 has a very strong inhibitory effect on gastric mucosal H+/K+ ATPase, and the inhibitory effect is more significant at low pH. At the same time, there is no selectivity difference between the two enantiomers of H+/K+ ATPase, and its inhibitory effect can be studied and verified by a variety of experimental methods, including inhibition of enzyme activity, proton transport, and studies on its binding.
Cat. No.: HY-17507S2
CAS No.: 934294-34-5
Synonyms: BY1023-d8; SKF96022-d8
Cat. No.: HY-17507S4
CAS No.: 934294-71-0
Synonyms: BY1023-d4; SKF96022-d4
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Thonzonium (bromide) (Standard) is the analytical standard of Thonzonium (bromide). This product is intended for research and analytical applications. Thonzonium bromide is an antibacterial agent that is structurally similar to Farnesol (HY-Y0248A). Thonzonium bromide is also a monocationic surface-active agent, which inhibits RANKL-induced osteoclast formation and bone resorption in vitro and prevents LPS-induced bone loss in vivo. Thonzonium bromide inhibits proton transport in a dose-dependent manner (EC50=69 μM) .
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Cat. No.: HY-W739793
Synonyms: BY1023-d8 sodium; SKF96022-d8 sodium
Cat. No.: HY-139994
CAS No.: 2820169-36-4
Synonyms: XP
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XN methyl pyrazole (XP) is an orally active, blood-brain barrier permeable uncoupler/proton carrier. XN methyl pyrazole uncouples oxidative phosphorylation, depolarizes mitochondrial transmembrane potential, increases energy expenditure, spontaneous activity levels, and cortical inosine monophosphate levels. XN methyl pyrazole reduces plasma purine and energy metabolite levels, improves glucose tolerance, and decreases weight gain, while avoiding potential estrogenic side effects. XN methyl pyrazole can be used in studies related to diet-induced obesity and insulin resistance .
Cat. No.: HY-Y1309S1
CAS No.: 124251-84-9
Synonyms: Furro ER-d7; NSC 9586-d7; Nako TRB-d7
Cat. No.: HY-100560R
CAS No.: 21293-29-8
Synonyms: (S)-(+)-Abscisic acid (Standard); ABA (Standard)
Cat. No.: HY-D1739
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DDAO phosphate diTEA is an amphoteric surfactant derived from DDAO (dimethyldodecylamine oxide). The head group of DDAO in DDAO phosphate diTEA exists in a non-ionic state at pH > 7 and in a cationic state at pH < 5 due to protonation of the oxygen atom. When combined with the anionic surfactant SDS, DDAO can incorporate into mixed micelles, reducing the net micellar charge and attenuating electrostatic repulsion between SDS head groups. DDAO can be used to formulate the ONOO⁻-targeting probe DDAO-PN, which generates significant near-infrared fluorescence at 657 nm .
Cat. No.: HY-D3163
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Endo-pH is a cell-permeable, pH-responsive fluorescent probe based on BODIPY, with a pKa of 5.08. When pH decreases from 7.32 to 4.97, Endo-pH undergoes protonation under acidic conditions, resulting in a 79-fold increase in fluorescence intensity at 786 nm. The detection wavelengths of its protonated form are Ex/Em=688/786 nm, while the absorption wavelength of its non-protonated form is 745 nm. Endo-pH can be used for staining late endosomes in live cells and determining the fusion time of late endosomes and lysosomes .
Cat. No.: HY-P10794
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Cat. No.: HY-185180
CAS No.: 14836-73-8
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Ferrioxamine B is a bacterial desferrioxamine siderophore produced by actinomycetes. Ferrioxamine B acts as a ligand for FpvB and FoxA, and is transported into Pseudomonas aeruginosa via the FpvB and FoxA transporters. Ferrioxamine B competitively binds to FpvB, thereby antagonizing the uptake of thiostrepton into Pseudomonas aeruginosa. Ferrioxamine B can provide an iron source to support the growth of Pseudomonas aeruginosa under iron-limiting conditions .
Cat. No.: HY-126751
CAS No.: 331686-58-9
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DBM-819 is a reversible inhibitor of H⁺/K⁺-ATPase (H +/K +-ATPase), with an IC50 value of 5 μM. DBM-819 can reversibly block gastric acid secretion by inhibiting the proton pump in the gastric mucosa. It shows significant protective effects against duodenal ulcers induced by Cysteamine (HY-77591), gastric ulcers induced by Indomethacin (HY-14397), and gastric ulcers induced by Aspirin (HY-14654), with EC50 values of 6, 3.1, and 4 mg/kg respectively. DBM-819 can be used in ulcer prevention research .
Cat. No.: HY-184638
APTS Fe2O3 Nanoparticles (Aminated ferric oxide magnetic nanoparticles) are magnetic nanomaterials modified with amino functional groups using APTS. This material consists of a ferric oxide (Fe3O4) nanoparticle core and an amino (-NH2) surface modification layer. The aminated surface helps improve the biocompatibility of the nanoparticles and reduce cytotoxicity. The amino functional groups can be further chemically modified for coupling with biomolecules such as drugs, proteins, and nucleic acids. The amino functional groups undergo protonation at different pH values, resulting in different surface charges on the nanoparticles in different pH environments.
Cat. No.: HY-187478A
Synonyms: DOPE-PEG2000-Mal-Cys-LIRLWSHLIHIWFQNRRLKWKKK
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DOPE-PEG2000-EB1 (DOPE-PEG2000-Mal-Cys-LIRLWSHLIHIWFQNRRLKWKKK) is an amphiphilic lipid-PEG-peptide conjugate composed of DOPE (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine), PEG2000, and the EB1 peptide (a penetratin analog). EB1 peptide is an endosomolytic agent that forms an amphipathic alpha helix upon protonation in endosomes, driving endosomal membrane permeabilization. DOPE-PEG2000-EB1 is used for intracellular delivery of nucleic acids (e.g., siRNA) and other macromolecular therapeutics.
Cat. No.: HY-D3130
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Mem-pH is a ratiometric fluorescent probe used for measuring vesicular pH. Mem-pH inserts into the plasma membrane bilayer and localizes to the vesicular lumen, switching between its basic and acidic forms via protonation during vesicular acidification to enable ratiometric pH readout. In aqueous media, Mem-pH forms non-emissive aggregates through aggregation-induced quenching, and then depolymerizes and recovers its fluorescent activity upon binding to the plasma membrane. The excitation/emission wavelengths of the basic form of Mem-pH are 405/450-550 nm, while those of the acidic form are 488/500-700 nm .
Cat. No.: HY-W251598B
CAS No.: 144-55-8
Synonyms: Sodium hydrogen carbonate for molecular biology; Soda bicarbonate for molecular biology
Cat. No.: HY-L011
2,278 compounds
Most of molecules enter or leave cells mainly via membrane transport proteins, which play important roles in several cellular functions, including cell metabolism, ion homeostasis, signal transduction, the recognition process in the immune system, energy transduction, etc. There are three major types of transport proteins, ATP-powered pumps, channel proteins and transporters. Transport proteins such as channels and transporters play important roles in the maintenance of intracellular homeostasis, and mutations in these transport protein genes have been identified in the pathogenesis of a number of hereditary diseases. In the central nervous system, ion channels have been linked to, but not limited to, many diseases such asataxias, paralyses, epilepsies, and deafness. This indicates the roles of ion channels in the initiation and coordination of movement, sensory perception, and encoding and processing of information. Ion channels are a major class of drug targets in drug development.
MCE designs a unique collection of 2,278 smal-molecule modulators that can be used for the research of Ion Channel and Membrane Transporter or high throughput screening (HTS) related drug discovery.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
