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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
41 Results for "
ALK3
" in MedChemExpress (MCE) Product Catalog:
Products (41)
41 Results for "ALK3" in MCE Product Catalog:
Cat. No.: HY-17661
CAS No.: 1062368-55-1
Synonyms: Depiperazine-LDN-193189
Target:
Research Areas:
Depiperazine-DM3189 is a derivative of LDN193189 (HY-12071). LDN193189 is a potent selective BMP type I receptor (BMP I) inhibitor. LDN-193189 efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 values of 5 nM and 30 nM, respectively. LDN-193189 can be used for the research of bone morphogenetic protein signalling, such as fibrodysplasia ossificans progressiva [3].
Cat. No.: HY-13418R
CAS No.: 1219168-18-9
Synonyms: Compound C dihydrochloride (Standard); BML-275 dihydrochloride (Standard)
Research Areas:
Dorsomorphin (dihydrochloride) (Standard) is the analytical standard of Dorsomorphin (dihydrochloride). This product is intended for research and analytical applications. Dorsomorphin (Compound C) dihydrochloride is a potent, selective and ATP-competitive AMPK inhibitor, with a Ki of 109 nM. Dorsomorphin dihydrochloride inhibits BMP pathway by targeting the type I receptors ALK2, ALK3, and ALK6. Dorsomorphin dihydrochloride can reverse autophagy activation and anti-inflammatory effect of Urolithin A (HY-100599).
Cat. No.: HY-12071AR
CAS No.: 2310134-98-4
Synonyms: DM-3189 Tetrahydrochloride (Standard)
Research Areas:
LDN193189 (DM-3189) Tetrahydrochloride (Standard) is the analytical standard of LDN193189 Tetrahydrochloride (HY-12071A). This product is intended for research and analytical applications. LDN193189 (DM-3189) Tetrahydrochloride is a potent selective BMP type I receptor (BMP I) inhibitor. LDN193189 efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 values of 5 nM and 30 nM, respectively. LDN193189 can be used for the research of bone morphogenetic protein signalling, such as fibrodysplasia ossificans progressiva [3].
Cat. No.: HY-P7484
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: BMPR1A; BMP Type-1A Receptor; Prev. ACVRLK3; ALK-3; ALK3; SKR5; CD292; Activin A Receptor, Type II-Like Kinase 3; Bone Morphogenetic Protein Receptor, Type IA; Receptor Protein Serine/Threonine Kinase; Bone Morphogenetic Protein Receptor Type-1A; CD292 An
Species:
Human
Source:
HEK293
Cat. No.: HY-P7483
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: BMPR1A; BMP Type-1A Receptor; Prev. ACVRLK3; ALK-3; ALK3; SKR5; CD292; Activin A Receptor, Type II-Like Kinase 3; Bone Morphogenetic Protein Receptor, Type IA; Receptor Protein Serine/Threonine Kinase; Bone Morphogenetic Protein Receptor Type-1A; CD292 An
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P75594
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: BMPR1A; BMP Type-1A Receptor; Prev. ACVRLK3; ALK-3; ALK3; SKR5; CD292; Activin A Receptor, Type II-Like Kinase 3; Bone Morphogenetic Protein Receptor, Type IA; Receptor Protein Serine/Threonine Kinase; Bone Morphogenetic Protein Receptor Type-1A; CD292 An
Species:
Human
Source:
HEK293
Cat. No.: HY-P703876
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: BMPR1A; BMP Type-1A Receptor; Prev. ACVRLK3; ALK-3; ALK3; SKR5; CD292; Activin A Receptor, Type II-Like Kinase 3; Bone Morphogenetic Protein Receptor, Type IA; Receptor Protein Serine/Threonine Kinase; Bone Morphogenetic Protein Receptor Type-1A; CD292 An
Species:
Human
Source:
HEK293
Cat. No.: HY-P76173
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: BMPR1A; BMP Type-1A Receptor; Prev. ACVRLK3; ALK-3; ALK3; SKR5; CD292; Activin A Receptor, Type II-Like Kinase 3; Bone Morphogenetic Protein Receptor, Type IA; Receptor Protein Serine/Threonine Kinase; Bone Morphogenetic Protein Receptor Type-1A; CD292 An
Species:
Canine
Source:
HEK293
Cat. No.: HY-179400
CAS No.: 1062368-51-7
Research Areas:
LDN-193688 (Compound 26) is a ALK2 inhibitor, with IC₅₀ values of 104, 18, 235, 1530, and 1080 nM against ALK1, ALK2, ALK3, ALK4, and ALK5, respectively. LDN-193688 inhibits bone morphogenetic protein 4 (BMP4)-induced phosphorylation of SMAD1/5/8, with an IC₅₀ of 2.6 μM .
Cat. No.: HY-12071R
CAS No.: 1062368-24-4
Synonyms: DM-3189 (Standard)
Research Areas:
LDN193189 (Standard) is the analytical standard of LDN193189 (HY-12071). This product is intended for research and analytical applications. LDN193189 (DM-3189) is a potent selective BMP type I receptor (BMP I) inhibitor. LDN193189 efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 values of 5 nM and 30 nM, respectively. LDN193189 can be used for the research of bone morphogenetic protein signalling, such as fibrodysplasia ossificans progressiva [3].
Cat. No.: HY-RS01546
Target:
Research Areas:
BMPR1A Human Pre-designed siRNA Set A contains three designed siRNAs for BMPR1A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS01547
Target:
Research Areas:
Bmpr1a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bmpr1a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-13418AR
CAS No.: 866405-64-3
Synonyms: BML-275 (Standard)
Research Areas:
Dorsomorphin (Standard) is the analytical standard of Dorsomorphin (HY-13418A). This product is intended for research and analytical applications. Dorsomorphin (BML-275) is a selective and ATP-competitive AMPK inhibitor (Ki=109 nM in the absence of AMP). Dorsomorphin (BML-275) selectively inhibits BMP type I receptors ALK2, ALK3, and ALK6. Dorsomorphin can reverse autophagy activation and anti-inflammatory effect of Urolithin A (HY-100599) .
Cat. No.: HY-155227B
CAS No.: 2730432-72-9
Target:
Research Areas:
ALK/EGFR-IN-3 is a dual inhibitor of ALK and EGFR. ALK/EGFR-IN-3 inhibits the cell proliferation of H1975, PC9, and Baf3-EML4-ALK cancer cell lines with IC50s of 0.1360, 0.0332, and 0.0339 μM, respectively .
Cat. No.: HY-171248
CAS No.: 3034215-86-3
Research Areas:
CDD-1115 is a BMPR2 serine/threonine kinase inhibitor with an IC50 of 1.8 nM against human BMPR2 kinase. CDD-1115 selectively inhibits the catalytic activity of BMPR2, and shows weak inhibitory effects on ALK1 and ALK2 .
Cat. No.: HY-155227A
CAS No.: 2730432-75-2
Target:
Research Areas:
ALK/EGFR-IN-2 is a potent dual inhibitor of ALK and EGFR. ALK/EGFR-IN-2 induces apoptosis and G0/G1 cell cycle arrest in cancer cells. ALK/EGFR-IN-2 significantly inhibits the cell proliferation of H1975, PC9, and Baf3-EML4-ALK cancer cell lines with IC50s of 0.0034, 0.0065, and 0.0018 μM, respectively .
Cat. No.: HY-12278G
CAS No.: 1431985-92-0
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
