K02288 (GMP) is K02288 (HY-12278) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. K02288 is a potent bone morphogenetic protein (BMP) type I receptor inhibitor with IC50s of 1.8, 1.1, 6.4 nM for ALK1, ALK2 and ALK6, respectively. K02288 shows slightly weaker inhibition against ALK3 and ALK6 with IC50s of of 5-34 nM.
For research use only. We do not sell to patients.
- CAS No.: 1431985-92-0
- Formula: C20H20N2O4
- Molecular Weight:352.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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HY-12278
K02288BMPI Inhibitor -
HY-13226
GalunisertibTGFβRI Inhibitor -
HY-15897
LDN-212854ALK2 Inhibitor -
HY-12273
DMH-1BMP Inhibitor -
HY-10431
SB-431542TGF-β Receptor Kinase Inhibitor -
HY-12071
LDN193189ALK2/3 Inhibitor -
HY-13012
RepSoxTGFβR-1/ALK5 Inhibitor -
HY-10431G
SB-431542 (GMP)TGF-β Receptor Kinase Inhibitor -
HY-12075
LY2109761TGF-βR I/II Inhibitor -
HY-10432
A 83-01ALK4/5/7 Inhibitor -
HY-10326
GW788388ALK5 Inhibitor -
HY-13227
SD-208TGF-β Receptor Inhibitor
Biological Activity
Description
In Vitro
K02288 (GMP) reduces a robust phosphorylation of Smad1/5/8 induced by BMP4 stimulation, with an apparent IC50 of 100 nM. K02288 (GMP) causes near complete inhibition of Smad2 phosphorylation at 0.5 μM[1].
K02288 (GMP) binds to ALK1 in an ATP-mimetic fashion with two hydrogen bonds to the kinase hinge. K02288 (GMP) also inhibits BMP9-ALK1 signalling, and induces a hypersprouting phenotype in HUVECs[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1431985-92-0
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Molecular Weight 352.38
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Formula C20H20N2O4
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SMILES
OC1=CC=CC(C2=CC(C3=CC(OC)=C(OC)C(OC)=C3)=C(N)N=C2)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Sanvitale CE, et al. A new class of small molecule inhibitor of BMP signaling. PLoS One. 2013 Apr 30;8(4):e62721. [Content Brief]
[2]. Kerr G, et al. A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis. Angiogenesis. 2015 Apr;18(2):209-17. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
K02288 (GMP) Related Classifications
HY-12278G Related Classifications
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