K02288 (GMP) is K02288 (HY-12278) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. K02288 is a potent bone morphogenetic protein (BMP) type I receptor inhibitor with IC50s of 1.8, 1.1, 6.4 nM for ALK1, ALK2 and ALK6, respectively. K02288 shows slightly weaker inhibition against ALK3 and ALK6 with IC50s of of 5-34 nM.
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- CAS 番号: 1431985-92-0
- 分子式: C20H20N2O4
- 分子量:352.38
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-12278
K02288BMPI Inhibitor -
HY-13226
GalunisertibTGFβRI Inhibitor -
HY-15897
LDN-212854ALK2 Inhibitor -
HY-12273
DMH-1BMP Inhibitor -
HY-10431
SB-431542TGF-β Receptor Kinase Inhibitor -
HY-12071
LDN193189ALK2/3 Inhibitor -
HY-13012
RepSoxTGFβR-1/ALK5 Inhibitor -
HY-10431G
SB-431542 (GMP)TGF-β Receptor Kinase Inhibitor -
HY-12075
LY2109761TGF-βR I/II Inhibitor -
HY-10432
A 83-01ALK4/5/7 Inhibitor -
HY-10326
GW788388ALK5 Inhibitor -
HY-13227
SD-208TGF-β Receptor Inhibitor
生物活性
製品説明
体外実験
K02288 (GMP) reduces a robust phosphorylation of Smad1/5/8 induced by BMP4 stimulation, with an apparent IC50 of 100 nM. K02288 (GMP) causes near complete inhibition of Smad2 phosphorylation at 0.5 μM[1].
K02288 (GMP) binds to ALK1 in an ATP-mimetic fashion with two hydrogen bonds to the kinase hinge. K02288 (GMP) also inhibits BMP9-ALK1 signalling, and induces a hypersprouting phenotype in HUVECs[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1431985-92-0
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分子量 352.38
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分子式 C20H20N2O4
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SMILES
OC1=CC=CC(C2=CC(C3=CC(OC)=C(OC)C(OC)=C3)=C(N)N=C2)=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Sanvitale CE, et al. A new class of small molecule inhibitor of BMP signaling. PLoS One. 2013 Apr 30;8(4):e62721. [Content Brief]
[2]. Kerr G, et al. A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis. Angiogenesis. 2015 Apr;18(2):209-17. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
K02288 (GMP) 関連分類
HY-12278G 関連分類
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