Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
54 Results for "
ALR
" in MedChemExpress (MCE) Product Catalog:
Products (54)
54 Results for "ALR" in MCE Product Catalog:
Cat. No.: HY-146661
CAS No.: 2446136-17-8
Target:
Research Areas:
Aldose reductase-IN-4 (compund IIc) is an aldose reductase inhibitor with IC50s of 11.70 μM and 0.98 μM for aldehyde reductase 1 (ALR1) and ALR2, respectively .
Cat. No.: HY-RS24841
Target:
Research Areas:
Gfer Rat Pre-designed siRNA Set A contains three designed siRNAs for Gfer gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS18362
Target:
Research Areas:
Gfer Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gfer gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-146129
CAS No.: 2480090-03-5
Target:
Research Areas:
As an aldose reductase (ALR2) inhibitor, the compound is used to enhance the combination of inhibitory excitability and antioxidant capacity to delay the progress of diabetes complications.
Cat. No.: HY-D0064
CAS No.: 88404-14-2
Cat. No.: HY-RS00531
Target:
Research Areas:
AKR1A1 Human Pre-designed siRNA Set A contains three designed siRNAs for AKR1A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-175854
Target:
Research Areas:
Aldose reductase-IN-9 (Compound 8b) is an Aldose reductase (ALR2) inhibitor with a Ki value of 3.59 nM. Aldose reductase-IN-9 has anti-tumor activity .
Cat. No.: HY-RS17767
Target:
Research Areas:
Kmt2d Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kmt2d gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-184283
Target:
Research Areas:
ALR2-IN-11 is a competitive aldose reductase (ALR2) inhibitor with a Ki value of 0.052 μM. ALR2-IN-11 can be used for the research of diabetic complications .
Cat. No.: HY-W283860
CAS No.: 135-64-8
Target:
Research Areas:
ALR2-IN-10 (Compound 23) is a weak Aldose Reductase 2 inhibitor with inhibition rate of 6% at 27 μM. ALR2-IN-10 can be used for the research of diabetic complication .
Cat. No.: HY-184330
Target:
Research Areas:
ALR2/α-Glucosidase-IN-2 is an inhibitor of α-glucosidase and aldose reductase ALR2. ALR2/α-Glucosidase-IN-2 has a Ki value of 11.68 nM against yeast α-glucosidase and a Ki value of 72.64 nM against ovine ALR2. ALR2/α-Glucosidase-IN-2 inhibits intestinal carbohydrate digestion regulatory enzymes and key enzymes in the polyol pathway. ALR2/α-Glucosidase-IN-2 can be used in diabetes-related research .
Cat. No.: HY-182311
Target:
Research Areas:
ALR2/α-Glucosidase-IN-1 (Compound 4) is a competitive ALR2 inhibitor and competitive α-glucosidase inhibitor, with an IC50 of 0.250 μM against ALR2 and an IC50 of 0.561 μM against α-glucosidase. ALR2/α-Glucosidase-IN-1 binds to the active sites of ALR2 and α-glucosidase, and inhibits enzymatic activity by competing with their respective substrates. ALR2/α-Glucosidase-IN-1 can be used in diabetes-related research .
Cat. No.: HY-181519
Research Areas:
ALR2/α-GLY-IN-1 is a potent dual-target inhibitor that targets aldose reductase ALR2 and α-glucosidase (IC50 values are 0.72 μM and 0.82 μM, respectively; Ki values are 1.67 μM and 1.37 μM, respectively). ALR2/α-GLY-IN-1 also acts as a DNA binder, which stably interacts with calf thymus double-stranded DNA through non-covalent interactions such as groove-binding mode and water-bridged hydrogen bonds. ALR2/α-GLY-IN-1 can be used in studies related to diabetes and its complications .
Cat. No.: HY-106697R
CAS No.: 72702-95-5
Synonyms: ICI 128436 (Standard)
Target:
Research Areas:
Ponalrestat (Standard) (ICI 128436 (Standard)) is the analytical standard of Ponalrestat (HY-106697). This product is intended for research and analytical applications. Ponalrestat (ICI 128436) is an orally active, selective and noncompetitive aldose reductase (AKR1B1; ALR) inhibitor. Ponalrestat selectively inhibits ALR2 (Ki=7.7 nM) over ALR1 (Ki=60 μM). Ponalrestat inhibits the conversion of glucose to sorbitol .
Cat. No.: HY-P703415
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: AKR1A1; HEL-S-6; Aldo-Keto Reductase Family 1 Member A1; ALDR1; Aldehyde Reductase; ScorR; ALR; Aldo-Keto Reductase Family 1, Member A1 (Aldehyde Reductase); Glucuronolactone Reductase; Epididymis Secretory Sperm Binding Protein Li 165mP; S-Nitroso-CoA Re
Species:
Others
Source:
E. coli
Cat. No.: HY-P76137
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: AKR1A1; HEL-S-6; Aldo-Keto Reductase Family 1 Member A1; ALDR1; Aldehyde Reductase; ScorR; ALR; Aldo-Keto Reductase Family 1, Member A1 (Aldehyde Reductase); Glucuronolactone Reductase; Epididymis Secretory Sperm Binding Protein Li 165mP; S-Nitroso-CoA Re
Species:
Human
Source:
E. coli
Cat. No.: HY-W151897
CAS No.: 309283-89-4
Synonyms: CMTI
Target:
Research Areas:
Cemtirestat (CMTI) is a carboxymethylated thiatriazinoindole inhibitor of aldose reductase (ALR2). Cemtirestat potently inhibits rat ocular lens ALR2 with an IC50 of 0.116 μM, and exhibits a 302-fold selectivity for rat kidney ALR1. Cemtirestat is applicable to the research of advanced diabetic complications .
Cat. No.: HY-187119
CAS No.: 158575-73-6
Target:
Research Areas:
CC13401 is an aldose reductase (ALR2) inhibitor with an IC50 of 41.41 μM in rats. CC13401 inhibits the NADPH-dependent reduction reaction catalyzed by ALR2. CC13401 can be used in studies on the mechanisms related to the polyol pathway and diabetic complications .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
