309283-89-4
309283-89-4
Chemical Structure
Cemtirestat
Synonym(s): CMTI
- CAS No.: 309283-89-4
- Formula:C11H8N4O2S
- Molecular Weight:260.27
IUPAC Name: 2-(3-thioxo-3,4-dihydro-5H-[1,2,4]triazino[5,6-b]indol-5-yl)acetic acid
InChIKey: LCMDWJXBUZDEKA-UHFFFAOYSA-N
SMILES: O=C(O)CN1C=2C=CC=CC2C=3N=NC(=S)NC31
Biological Activity: Cemtirestat (CMTI) is a carboxymethylated thiatriazinoindole inhibitor of aldose reductase (ALR2). Cemtirestat potently inhibits rat ocular lens ALR2 with an IC50 of 0.116 μM, and exhibits a 302-fold selectivity for rat kidney ALR1. Cemtirestat is applicable to the research of advanced diabetic complications[1].
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Cemtirestat | Cemtirestat (CMTI) is a carboxymethylated thiatriazinoindole inhibitor of aldose reductase (ALR2). Cemtirestat potently inhibits rat ocular lens ALR2 with an IC50 of 0.116 μM, and exhibits a 302-fold selectivity for rat kidney ALR1. Cemtirestat is applicable to the research of advanced diabetic complications. | |||||||||||||||||||||
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