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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
84 Results for "
DDB
" in MedChemExpress (MCE) Product Catalog:
Products (84)
84 Results for "DDB" in MCE Product Catalog:
Cat. No.: HY-150641
CAS No.: 3031561-92-6
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CDK-IN-9 (compound 24) is a potent CDK inhibitor, also as a molecular glue inducing an interaction between CDK12 and DDB1, with an IC50 values of 4 nM for CDK2/E. CDK-IN-9 leads to polyubiquitination of cyclin K and its subsequent degradation. CDK-IN-9 induce apoptosis through dephosphorylation of retinoblastoma protein and RNA polymerase II .
Cat. No.: HY-177780
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Cyclin K degrader 2 is a molecular glue degrader of Cyclin K. By bridging CDK12 and DDB1, the receptor of the CRL4 E3 ligase, Cyclin K degrader 2 specifically induces the targeted degradation of Cyclin K within the CDK12-Cyclin K complex. Cyclin K degrader 2 can be used in studies related to acute myeloid leukemia .
Cat. No.: HY-170900
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SJ44236 is a BET PROTAC degrader with activity against BRD2, BRD3 and BRD4 (DC50 = 127 pM). SJ44236 induces ubiquitination and proteasomal degradation by forming a ternary complex with BET proteins and CRBN-DDB1. SJ44236 downregulates c-Myc, upregulates p53 and reduces cancer cell viability. SJ44236 can be used for the research of leukemia and medulloblastoma .
Cat. No.: HY-177559
CAS No.: 3037413-54-7
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NEK7 degrader-2 is a NEK7 molecular glue degrader that promotes the formation of the NEK7-compound-CRBN/DDB1 ternary complex. NEK7 degrader-2 reduces the release of IL-1β after NLRP3 inflammasome activation induced by LPS (HY-D1056). NEK7 degrader-2 can be applied in studies related to NEK7-dependent NLRP3 inflammasome activation and inflammatory responses .
Cat. No.: HY-175280
CAS No.: 3095033-62-5
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Lck degrader-1 is a molecular glue degrader that recruits cereblon to target LCK and CK1α. Lck degrader-1 promotes the formation of the LCK/CRBN-DDB1 ternary complex with an EC50 of 77.1 nM, and induces the degradation of LCK and CK1α. LCK degradation induced by Lck degrader-1 depends on the G415-containing helical G-loop degron, and maintains LCK-degrading activity in cells with the LCK T316I gatekeeper mutation. Lck degrader-1 can be used for research related to T-cell acute lymphoblastic leukemia (T-ALL) and LCK inhibitor resistance .
Cat. No.: HY-W018791R
CAS No.: 73536-69-3
Synonyms: DDB (Standard)
Research Areas:
Bifendate (DDB), extracted from Schisandrae chinensis, is an orally active anti-HBV agent against chronic hepatitis B. Bifendate inhibits ATG5-dependent autophagy and attenuates oleic acid-induced lipid accumulation with anti-oxidant properties in vitro. Bifendate can decrease alanine transaminase (ALT) level in mice. Bifendate attenuates hepatic steatosis in cholesterol/bile salt- and high-fat diet-induced hypercholesterolemia in mice. Bifendate potently increases the activity of cytochrome proteins (CYPs) and reverse P-gp-mediated multi-drug resistance (MDR) .
Cat. No.: HY-149441
CAS No.: 444579-59-3
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Indisulam analog-1 (Compound 4) is an analog of Indisulam (HY-13650). Indisulam analog-1 recruits DCAF15-DDB1-DDA1-RBM39 with an EC50 of 1.21 µM. Indisulam analog-1 can be used in the research of colon cancer .
Cat. No.: HY-173274
CAS No.: 3056259-55-0
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CB039 is a RBM39 molecular glue degrader with an IC50 of 36.7 nM against HCT-116 cells. CB039 induces RBM39 degradation in a dose- and time-dependent manner. This process depends on the Cullin-RING E3 ubiquitin ligase complex (CRL) and proteasome, and promotes the recruitment of RBM39 to the DCAF15-DDB1 complex with an IC50 of 594 nM. CB039 causes abnormal RNA splicing, reduces CEP192 protein levels, induces G2/M phase cell cycle arrest and mitotic spindle disorder. CB039 can be used in studies on RBM39-targeted protein degradation and colorectal cancer-related mechanisms .
Cat. No.: HY-177786
CAS No.: 3093763-27-7
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CDK12 ligand-3 is a monovalent CDK12/13 and cyclin K molecular glue degrader. CDK12 ligand-3 recruits DDB1, a core component of CUL4-based E3 ubiquitin ligase complexes, to drive ubiquitination and degradation of its targets .
Cat. No.: HY-161632
CAS No.: 3034244-56-6
PROTAC EGFR degrader 10 (Compound B56) is a PROTAC degrader for epidermal growth factor receptor (EGFR), with DC50 <100 nM. PROTAC EGFR degrader 10 binds CRBN-DDB1 with a Ki of 37 nM. PROTAC EGFR degrader 10 degrades EGFR, focal adhesion kinase (FAK), and RSK1, inhibits the proliferation of BaF3 wild type and EGFR mutants, with IC50 <150 nM .
Cat. No.: HY-RS03606
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DDB1 Human Pre-designed siRNA Set A contains three designed siRNAs for DDB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS03607
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DDB2 Human Pre-designed siRNA Set A contains three designed siRNAs for DDB2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS24422
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Ddb1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ddb1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P11028
Cat. No.: HY-182983
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DDB1 ligand-1 is a DNA damage-binding protein 1 (DDB1) ligand. DDB1 ligand-1 binds to a unique pocket on the β propeller C (BPC) domain of DDB1, induces conformational changes, and blocks the canonical DCAF/HBx peptide binding site of DDB1. DDB1 ligand-1 engages full-length DDB1 in cellular settings and supports PROTAC development research .
Cat. No.: HY-184425
HBx-DDB1-IN-1 is an orally active HBx-DDB1 protein-protein interaction inhibitor and antiviral agent. HBx-DDB1-IN-1 interferes with HBx-mediated Smc5/6 degradation, thereby partially restoring Smc6 protein levels. HBx-DDB1-IN-1 can be used for the research of chronic hepatitis B virus infection .
Cat. No.: HY-RS17951
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Ddb1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ddb1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS18473
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Ddb2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ddb2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS24954
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Ddb2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ddb2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
