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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
25 Results for "
MYC/MAX
" in MedChemExpress (MCE) Product Catalog:
Products (25)
25 Results for "MYC/MAX" in MCE Product Catalog:
Cat. No.: HY-12702R
CAS No.: 403811-55-2
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10058-F4 (Standard) is the analytical standard of 10058-F4 (HY-12702). This product is intended for research and analytical applications. 10058-F4 is a c-Myc inhibitor that prevents c-Myc-Max dimerization and transactivation of c-Myc target gene expression.
Cat. No.: HY-100669R
CAS No.: 944547-46-0
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Mycro 3 (Standard) is the analytical standard of Mycro 3 (HY-100669). This product is intended for research and analytical applications. Mycro 3 is an orally active, potent and selective inhibitor of Myc-associated factor X (MAX) dimerization. Mycro 3 also inhibit DNA binding of c-Myc . Mycro 3 could be used for the research of pancreatic cancer .
Cat. No.: HY-100996R
CAS No.: 413611-93-5
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10074-G5 (Standard) is the analytical standard of 10074-G5 (HY-100996). This product is intended for research and analytical applications. 10074-G5 is an inhibitor of c-Myc-Max dimerization with an IC50 of 146 μM.
Cat. No.: HY-159756
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KI-MS2-008b is the enantiomer of KI-MS2-008 (HY-159756B). KI-MS2-008 is a selective Max binder. KI-MS2-008 exhibits anticancer activity against Myc-dependent cancers .
Cat. No.: HY-L109
826 compounds
Protein protein interactions (PPI) have pivotal roles in life processes. The studies showed that aberrant PPI are associated with various diseases, including cancer, infectious diseases, and neurodegenerative diseases. The classic drug targets are usually enzymes, ion channels, or receptors, the PPI indicate new potential therapeutic targets. Therefore, targeting PPI is a new direction in treating diseases and an essential strategy for the development of new drugs.
However, the design of modulators targeting PPI still faces tremendous challenges, such the difficult PPI interfaces for the drug design, lack of ligands reference, lack of guidance rules for the PPI modulators development and high-resolution PPI proteins structures.
With the development of high-throughput technology, high-throughput screening is also gradually used for the identification of PPI inhibitors, but the compound library used for conventional target screening is not very effective in screening PPI inhibitors. To improve screening efficiency, MCE carefully selected 826 PPI inhibitors and mainly targeting MDM2-p53, Keap1-Nrf2, PD-1/PD-L1, Myc-Max, etc. MCE Protein-protein Interaction Inhibitor Library is a useful tool for PPI drug discovery and related research.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
