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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
37 Results for "
Reserpine
" in MedChemExpress (MCE) Product Catalog:
Products (37)
37 Results for "Reserpine" in MCE Product Catalog:
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OPC 4392 hydrochloride is an agonist for presynaptic dopamine receptor and an antagonist for postsynaptic D2 receptor. OPC 4392 reverses the Reserpine (HY-N0480)-induced dopamine accumulation, inhibits Apomorphine (HY-12723)-induced stereotypic and climbing behaviors in mouse models .
Cat. No.: HY-171033
CAS No.: 2342576-75-2
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ASM-IN-3 (Compound 21b) is a selective and BBB-penetrating acid sphingomyelinase (ASM) inhibitor (IC50: 3.37 μM for pure human ASM). ASM-IN-3 improves depression-like behaviors by inhibiting ASM activity and increasing neurogenesis in hippocampus in Reserpine (HY-N0480)-induced depressed rats .
Cat. No.: HY-105973
CAS No.: 71827-56-0
Synonyms: BRL 14342
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Clemeprol (BRL 14342) is an orally active Noradrenaline (NA) and 5-HT uptake blocker. Clemeprol inhibits 6-
Hydroxydopamine (HY-B1081)-induced depletion of brain NA. Clemeprol exerts a dose-dependent inhibition of Reserpine (HY-N0480)-induced hypothermia. Clemeprol can be used in the research of depression .
Cat. No.: HY-100679B
CAS No.: 1821379-62-7
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(R)-Pirlindole mesylate is selective and reversible a Monoamine oxidase A (MAO-A) inhibitor with an IC50 of 0.43 μM for MAO-A over MAO-B. (R)-Pirlindole mesylate has an antidepressant activity. (R)-Pirlindole mesylate significantly decreases immobility time of the forced swim test and inhibits Reserpine (HY-N0480)-induced palpebral ptosis in behavioural mice models. (R)-Pirlindole mesylate can be used for depression research .
Cat. No.: HY-131527
CAS No.: 93413-90-2
Synonyms: N-Desmethyl Venlafaxine hydrochloride; Wy 45494
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Wy-45494 hydrochloride (N-Desmethyl Venlafaxine hydrochloride; Wy 45494) is a minor active metabolite of the selective norepinephrine and serotonin reuptake inhibitor (SNRI) venlafaxine. It is formed from venlafaxine via the cytochrome P450 (CYP) isomer CYP3A4.2. Wy-45494 hydrochloride inhibits norepinephrine and serotonin reuptake in rat synaptosomal preparations (IC50s of 4.7 and 1.6 μM, respectively). In vivo, Wy-45494 hydrochloride reversed reserpine-induced hypothermia in mice at a minimum effective dose (MED) of 10 mg/kg.
Cat. No.: HY-B1716S1
Synonyms: L-5-HTP-d3-1; Oxitriptan-d3-1
Cat. No.: HY-N0913R
CAS No.: 13382-86-0
Cat. No.: HY-119468R
CAS No.: 32359-34-5
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Medifoxamine (Standard) is the analytical standard of Medifoxamine (HY-119468). This product is intended for research and analytical applications. Medifoxamine is an orally active monoamine reuptake inhibitor and antidepressant. Medifoxamine preferentially inhibits presynaptic dopamine reuptake. Medifoxamine acts as an intraocular pressure-lowering agent to reduce intraocular pressure, and also functions as a miotic agent to decrease pupil diameter. Medifoxamine exhibits characteristic properties of antidepressant compounds, including preventing hypothermia induced by Reserpine (HY-N0480) or Apomorphine (HY-12723), potentiating the toxic effects of Yohimbine (HY-N0127) in mice, and reducing immobility behavior in mice and rats in the "behavioral despair" model. Medifoxamine has no anticholinergic activity. Medifoxamine can be used in research related to depression .
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Bishomoreserpine is a reserpine analog with potent inhibitory effect .
Cat. No.: HY-106604
CAS No.: 70384-91-7
Synonyms: LM 1404
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Lortalamine (LM 1404) is a selective norepinephrine transporter inhibitor with an IC50 of <1 nM. Lortalamine is a non-tricyclic antidepressant. Lortalamine antagonises Reserpine (HY-N0480)-induced ptosis and hypothermia. Lortalamine inhibits norepinephrine uptake .
Cat. No.: HY-187059
CAS No.: 39640-15-8
Synonyms: EGYT-475; Trelibet
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Piberaline (EGYT-475; Trelibet) is a psychoactive piperazine derivative with stimulant and antidepressant effects. Piberaline antagonizes Reserpine (HY-N0480)-induced dopamine depletion. Piberaline can be used for research on depression and central nervous system disorders .
Cat. No.: HY-116707A
CAS No.: 1178-29-6
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Metoserpate hydrochloride is a reserpine-type sedative for poultry. Metoserpate hydrochloride reduces fear-related tonic immobility responses in chicks, inhibits neonatal imprinting approach behavior in an age-dependent manner, and controls hysteria in pullet flocks after administration via drinking water. Metoserpate hydrochloride can be used in studies related to avian fear, stress, imprinting learning and behavioral regulation .
Cat. No.: HY-106470
CAS No.: 20170-20-1
Synonyms: Pasalin
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Difenamizole (Pasalin) is an orally active pyrazole non-steroidal anti-inflammatory agent and pain inhibitor, which capable of crossing the blood-brain barrier. Difenamizole inhibits the release of catecholamines by monoaminergic neurons, reduces the concentrations of dopamine metabolites and normetanephrine (NE) in the striatum, and thereby regulates the levels of dopamine and norepinephrine in the brain. Difenamizole is not only antagonized by dopamine in the brain, but also exerts synergistic effects with Oxidopamine (6-OHDA) (HY-B1081/A), Phenoxybenzamine (HY-B0431), Reserpine (HY-N0480), and other agents. Difenamizole inhibits conditioned, emotional and aggressive behaviors in rodents, and can be used in studies of pain and related neurobehaviors .
Cat. No.: HY-184060
CAS No.: 1704716-36-8
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ASP8062 is an orally active, blood-brain barrier-permeable selective GABAB receptor positive allosteric modulator. ASP8062 enhances GABA-mediated activation of GABAB receptors and strengthens GABAergic neurotransmission. ASP8062 reverses Reserpine (HY-N0480)-induced myalgia, regulates the sleep-wake cycle, increases delta wave power during non-REM sleep, and impairs motor coordination at high doses. ASP8062 penetrates the central nervous system with a half-life of 40-50 h. ASP8062 can be used in research related to opioid use disorder, fibromyalgia, chronic pain, and alcohol use disorder .
Cat. No.: HY-B1716SA
Synonyms: L-5-HTP-d3 hydrate; Oxitriptan-d3 hydrate
Cat. No.: HY-177797
CAS No.: 30439-19-1
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5-Methoxytryptoline acts as a modulator of the Serotonin transporter complex, as well as a ligand for the 5-HT2A and 5-HT2C receptors, with Ki values of 130 nM and 140 nM for the 5-HT2A and 5-HT2C receptors, respectively. 5-Methoxytryptoline inhibits the active uptake of Serotonin (HY-B1473A) and Tryptamine (HY-B2132) in platelets. 5-Methoxytryptoline induces behavioral excitation, cortical electroencephalographic desynchronization, and dose-dependent elevation of plasma prolactin, followed by behavioral sedation and partial recovery of cortical electroencephalographic voltage. 5-Methoxytryptoline antagonizes Reserpine (HY-N0480)-induced sedation, reduced locomotor activity, and hypothermia. 5-Methoxytryptoline exerts dose-dependent effects on behavior and cortical electroencephalographic activity in freely moving rats. 5-Methoxytryptoline can be used in depression-related research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
