71827-56-0
71827-56-0
Chemical Structure
Clemeprol
Synonym(s): BRL 14342
- CAS No.: 71827-56-0
- Formula:C17H20ClNO
- Molecular Weight:289.80
IUPAC Name: 1-(3-chlorophenyl)-3-(dimethylamino)-1-phenylpropan-2-ol
InChIKey: KGSABFQIAANNPS-UHFFFAOYSA-N
SMILES: CN(C)CC(O)C(C1=CC=CC=C1)C2=CC(Cl)=CC=C2
Biological Activity: Clemeprol (BRL 14342) is an orally active Noradrenaline (NA) and 5-HT uptake blocker. Clemeprol inhibits 6- Hydroxydopamine (HY-B1081)-induced depletion of brain NA. Clemeprol exerts a dose-dependent inhibition of Reserpine (HY-N0480)-induced hypothermia. Clemeprol can be used in the research of depression[1][2].
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Clemeprol | Clemeprol (BRL 14342) is an orally active Noradrenaline (NA) and 5-HT uptake blocker. Clemeprol inhibits 6- Hydroxydopamine (HY-B1081)-induced depletion of brain NA. Clemeprol exerts a dose-dependent inhibition of Reserpine (HY-N0480)-induced hypothermia. Clemeprol can be used in the research of depression. | |||||||||||||||||||||
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References
- [1]. Clark JA, et al. Substituted 3-amino-1,1-diaryl-2-propanols as potential antidepressant agents. J Med Chem. 1979 Nov;22(11):1373-9. [Content Brief]
- [2]. Clark MS, et al. Pharmacological and biochemical properties of BRL 14342, a novel potential antidepressant drug. Neuropharmacology. 1980 Dec;19(12):1207-8. [Content Brief]
Keywords
