30 Results for "

RyR2

" in MedChemExpress (MCE) Product Catalog:
Products (30)

30 Results for "RyR2" in MCE Product Catalog:

Cat. No.: HY-W010950AR
CAS No.: 57415-44-8
Flecainide hydrochloride is an orally active antiarrhythmic agent. Flecainide hydrochloride can block sodium channels and inhibit calcium ion release mediated by the cardiac ryanodine receptor (RyR2). Flecainide hydrochloride can be used in the research of diseases such as catecholaminergic polymorphic ventricular tachycardia (CPVT) [2] .
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Cat. No.: HY-166478S
CAS No.: 1794817-24-5
Synonyms: Desmethylcarvedilol-d5; BM-14242-d5
O-Desmethyl carvedilol-d5 (Desmethylcarvedilol-d5) is deuterium labeled O-Desmethylcarvedilol. O-Desmethylcarvedilol (Desmethylcarvedilol) is an active metabolite of the non-selective β-adrenergic receptor (β-AR) antagonist Carvedilol (HY-B0006). O-Desmethylcarvedilol inhibits store-overload-induced calcium release in HEK293 cells expressing the ryanodine receptor 2 (RyR2) R4496C (RyR2 R4496C) mutation (IC50 = 7.62 μM). O-Desmethylcarvedilol reduces increases in heart rate and prevents decreases in diastolic blood pressure induced by Isoproterenol (HY-B0468) in conscious rabbits (ED50s = 32 and 5 μg/kg, respectively) [2].
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Cat. No.: HY-W010950R
CAS No.: 54143-55-4
Flecainide (Standard) is the analytical standard of Flecainide. This product is intended for research and analytical applications. Flecainide is an orally active antiarrhythmic agent. Flecainide can block sodium channels and inhibit calcium ion release mediated by the cardiac ryanodine receptor (RyR2). Flecainide can be used in the research of diseases such as catecholaminergic polymorphic ventricular tachycardia (CPVT) [2] .
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Cat. No.: HY-P5114
CAS No.: 269745-22-4
Target:  

Calcium Channel

Research Areas:  

Others

Maurocalcine is an agonist of ryanodine receptor (RyR) channel types 1, 2 and 3 with cellular permeability. Maurocalcine induces [ 3H]ryanodine binding on RyR1 with an EC50 value of 2558 nM. Maurocalcine exhibits a apparent affinity of 14 nM for RyR2. Maurocalcine can be applied to in vivo cell tracking or other cell imaging techniques [2] .
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Cat. No.: HY-113273B
CAS No.: 102783-61-9
Purity:  ≥96.0%
Synonyms: Ap5A pentaammonium; P1,P5-Di(adenosine-5'-)pentaphosphate pentaammonium
Target:  

Endogenous Metabolite

Diadenosine pentaphosphate (Ap5A; P1,P5-Di(adenosine-5'-)pentaphosphate) pentaammonium is an endogenous generated diadenosine polyphosphate, possessing the dual identities of intracellular alarm signal and extracellular signaling molecule. Diadenosine pentaphosphate regulates calcium signaling in the nervous, cardiac and peripheral sensory systems by activating P2X1/P2X3/P2Y receptor and RyR2 channels (EC50 = 140 μM). Diadenosine pentaphosphate can be used in studies related to intracellular calcium release channels, cardiovascular diseases and nociception (pain) [2] .
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Cat. No.: HY-113273C
CAS No.: 94108-02-8
Synonyms: Ap5A pentalithium; P1,P5-Di(adenosine-5'-)pentaphosphate pentalithium
Target:  

Endogenous Metabolite

Diadenosine pentaphosphate (Ap5A; P1,P5-Di(adenosine-5'-)pentaphosphate) pentalithium is an endogenous generated diadenosine polyphosphate, possessing the dual identities of intracellular alarm signal and extracellular signaling molecule. Diadenosine pentaphosphate regulates calcium signaling in the nervous, cardiac and peripheral sensory systems by activating P2X1/P2X3/P2Y receptor and RyR2 channels (EC50 = 140 μM). Diadenosine pentaphosphate can be used in studies related to intracellular calcium release channels, cardiovascular diseases and nociception (pain) [2] .
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Cat. No.: HY-P5494
Target:  

Inhibitory Antibodies

Research Areas:  

Others

DPc10 is a biological active peptide. (This is amino acids 2460 to 2495 fragment of cardiac ryanodine receptor (RyR2). RyR2 controls calcium release from the sarcoplasmic reticulum, which begins muscle contraction. Mutated RyR2 is associated to ventricular tachycardia (VT) and sudden death.)
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Cat. No.: HY-P811083
Synonyms: Ryanodine receptor 2, RyR-2, RyR2, hRyR-2, Cardiac muscle ryanodine receptor, Cardiac muscle ryanodine receptor-calcium release channel, Type 2 ryanodine receptor, RyR2

Host:  

Rabbit

Application:  

WB, IHC-P, ICC/IF

Reactivity:  

Human, Mouse, Rat, Rabbit

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Cat. No.: HY-103059R
CAS No.: 1479049-35-8
SOICR-IN-1 (Standard) is the analytical standard of SOICR-IN-1 (HY-103059). This product is intended for research and analytical applications. SOICR-IN-1 (compound 32) is a store-overload induced calcium release (SOICR) inhibitor with an IC50 value of 14.6 μM. SOICR-IN-1 can be used for the research of cardiac arrhythmias .
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Cat. No.: HY-D3579
Target:  

Fluorescent Dye

Research Areas:  

Others

AF568 C5 Maleimide is a bright orange-red thiol-reactive fluorescent dye. AF568 C5 Maleimide selectively labels the thiol groups on cysteine residues in proteins, peptides and antibodies via stable thioether bonds (Ex/Em = 575/600 nm) [2].
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