54143-55-4
54143-55-4
Chemical Structure
Flecainide
- CAS No.: 54143-55-4
- Formula:C17H20F6N2O3
- Molecular Weight:414.34
IUPAC Name: N-(piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide
InChIKey: DJBNUMBKLMJRSA-UHFFFAOYSA-N
SMILES: O=C(C1=CC(OCC(F)(F)F)=CC=C1OCC(F)(F)F)NCC2NCCCC2
Biological Activity: Flecainide is an orally active antiarrhythmic agent. Flecainide can block sodium channels and inhibit calcium ion release mediated by the cardiac ryanodine receptor (RyR2). Flecainide can be used in the research of diseases such as catecholaminergic polymorphic ventricular tachycardia (CPVT)[1][2].
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Flecainide | 99.98% | Flecainide is an orally active antiarrhythmic agent. Flecainide can block sodium channels and inhibit calcium ion release mediated by the cardiac ryanodine receptor (RyR2). Flecainide can be used in the research of diseases such as catecholaminergic polymorphic ventricular tachycardia (CPVT). | ||||||||||||||||||||
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Flecainide (Standard) | 99.52% | Flecainide (Standard) is the analytical standard of Flecainide. This product is intended for research and analytical applications. Flecainide is an orally active antiarrhythmic agent. Flecainide can block sodium channels and inhibit calcium ion release mediated by the cardiac ryanodine receptor (RyR2). Flecainide can be used in the research of diseases such as catecholaminergic polymorphic ventricular tachycardia (CPVT). | ||||||||||||||||||||
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Flecainide-d3 | 99.9% | Flecainide-d3 is the deuterium labeled Flecainide. Flecainide is an orally active antiarrhythmic agent. Flecainide can block sodium channels and inhibit calcium ion release mediated by the cardiac ryanodine receptor (RyR2). Flecainide can be used in the research of diseases such as catecholaminergic polymorphic ventricular tachycardia (CPVT). | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 1.00
HY-124883R-(–)-Flecainide -
Similarity Score 0.99
HY-W010950AFlecainide hydrochloride -
Similarity Score 0.94
HY-17429Flecainide acetate -
Similarity Score 0.82
HY-Z8177Flecainide Impurity 2 -
Similarity Score 0.71
HY-17429SFlecainide-d4 acetate -
Similarity Score 0.67
HY-Z8178Flecainide Impurity 3 -
Similarity Score 0.53
HY-112217APSEM 89S TFA -
Similarity Score 0.50
HY-160997Prosulpride -
Similarity Score 0.50
HY-B1059Levosulpiride -
Explore the MedChemAI to find more analogs
References
- [1]. Kuroda Y, et al. Flecainide ameliorates arrhythmogenicity through NCX flux in Andersen-Tawil syndrome-iPS cell-derived cardiomyocytes. Biochem Biophys Rep. 2017 Jan 11;9:245-256. [Content Brief]
- [2]. Watanabe H, et al. Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans. Nat Med. 2009 Apr;15(4):380-3. [Content Brief]
