21 Results for "

curcuminoid

" in MedChemExpress (MCE) Product Catalog:
Products (21)

21 Results for "curcuminoid" in MCE Product Catalog:

Bisdemethoxycurcumin
Bisdemethoxycurcumin
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Cat. No.: HY-N2942
CAS No.: 52328-96-8
Category:  

Zingiberaceae Extract Ketones, Aldehydes, Acids Alpinia officinarum Hance Plants

Target:  

PI3K Akt p38 MAPK PDK-1 mTOR Autophagy AMPK Keap1-Nrf2 Interleukin Related TNF Receptor NOD-like Receptor (NLR) Pyroptosis Bacterial

Bisdemethoxycurcumin is an orally effective curcuminoid. Bisdemethoxycurcumin downregulates pro-inflammatory cytokines in macrophages by inhibiting the phosphorylation of PI3K/Akt and p38 MAPK. Bisdemethoxycurcumin relieves autophagy inhibition and promotes lipophagy to clear vascular smooth muscle foam cells by inhibiting the PDK1/Akt/mTOR pathway. Bisdemethoxycurcumin activates the cAMP/Epac/AMPKα axis and the NRF2/HO-1 antioxidant axis, thereby indirectly inhibiting the phosphorylation of NF-κB p65 and pro-inflammatory outputs such as IL-1β/IL-6/TNF-α, so as to alleviate pulmonary oxidative stress, inflammatory infiltration and pulmonary edema. Bisdemethoxycurcumin blocks NLRP3-mediated pyroptosis and protects cartilage extracellular matrix degradation by activating NRF2/HO-1. Bisdemethoxycurcumin also exerts a synergistic effect with potassium iodide against Candida .
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