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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
42 Results for "
polycomb
" in MedChemExpress (MCE) Product Catalog:
Products (42)
42 Results for "polycomb" in MCE Product Catalog:
Target:
Research Areas:
EED ligand 1 is a diverse, potent, and efficacious inhibitor that target the EED subunit of the polycomb repressive complex 2 (PRC2) methyltransferase.
Cat. No.: HY-122640
CAS No.: 864819-54-5
Target:
Research Areas:
NPD13668 is an EZH2-mediated gene silencing modulator. NPD13668 inhibits EZH2/PRC2 (polycomb repressive complex 2) activity. NPD13668 reactivates the expression of silenced H3K27me3 target genes together with depletion of the H3K27me3 modification. NPD13668 can be used for the study of prostate cancer and ovarian cancer .
Cat. No.: HY-101512D
CAS No.: 2747996-65-0
Target:
Research Areas:
rel-A-395 hydrochloride is the relative configuration of A-395 (HY-101512) hydrochloride. A-395 is an antagonist of polycomb repressive complex 2 (PRC2) protein-protein interactions that potently inhibits the trimeric PRC2 complex (EZH2-EED-SUZ12) with an IC50 of 18 nM .
Cat. No.: HY-P2252
Target:
Research Areas:
Cat. No.: HY-P2253
Target:
Research Areas:
Cat. No.: HY-P701224
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: BMI1; BMI1 polycomb Ring Finger Proto-Oncogene; Prev. PCGF4; polycomb Group Ring Finger 4; RNF51; polycomb Group Protein Bmi1; polycomb Group RING Finger Protein 4; Ring Finger Protein 51; polycomb Complex Protein BMI-1; RING Finger Protein 51; B Lymphoma
Species:
Human
Source:
E. coli
Cat. No.: HY-124660A
CAS No.: 2089056-09-5
Target:
Research Areas:
A-395N serves as a control probe for A-395, a highly potent and selective chemical probe targeting the polycomb protein EED, a key player in Polycomb repressive complex 2 (PRC2) responsible for transcriptional repression via histone H3K27 methylation. While A-395N bears structural similarities to A-395, it demonstrates no pharmacological activity in biochemical or cellular assays, making it an ideal control compound.
Cat. No.: HY-P7614
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: ASXL1; Putative polycomb Group Protein ASXL1; ASXL Transcriptional Regulator 1; Additional Sex Combs-Like Protein 1; KIAA0978; polycomb Group Protein; Additional Sex Combs Like 1, Transcriptional Regulator; ASXL1 Protein; polycomb Group Protein ASXL1; ASX
Species:
Human
Source:
E. coli
Cat. No.: HY-P74179
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: EED; Embryonic Ectoderm Development Protein; Embryonic Ectoderm Development; Alternative Protein EED; HEED; polycomb Protein Eed; WD Protein Associating With Integrin Cytoplasmic Tails 1; COGIS; polycomb Protein EED; WAIT1; WAIT-1
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-100846R
CAS No.: 1913252-04-6
Research Areas:
JQEZ5 (Standard) is the analytical standard of JQEZ5 (HY-100846). This product is intended for research and analytical applications. JQEZ5 is a potent and selective EZH2 lysine methyltransferase inhibitor. JQEZ5 SAM-competitively inhibits polycomb repressive complex 2 (PRC2) with an IC50 of 80 nM. JQEZ5 has anti-tumor effects .
Cat. No.: HY-101512R
CAS No.: 2089148-72-9
Research Areas:
A-395 (Standard) is the analytical standard of A-395 (HY-101512). This product is intended for research and analytical applications. A-395, a chemical probe, is an antagonist of polycomb repressive complex 2 (PRC2) protein-protein interactions that potently inhibits the trimeric PRC2 complex (EZH2-EED-SUZ12) with an IC50 of 18 nM .
Cat. No.: HY-101117R
CAS No.: 2083627-02-3
Research Areas:
EED226 (Standard) is the analytical standard of EED226 (HY-101117). This product is intended for research and analytical applications. EED226 is a polycomb repressive complex 2 (PRC2) inhibitor, which binds to the K27me3-pocket on embryonic ectoderm development (EED) and shows strong antitumor activity in xenograft mice model . EED226 is a potent, selective, and orally bioavailable EED inhibitor . EED226 inhibits PRC2 with an IC50 of 23.4 nM when the H3K27me0 peptide is used as a substrate in the in vitro enzymatic assays .
Cat. No.: HY-L017
2,931 compounds
Adult stem cells are important for tissue homeostasis and regeneration due to their ability to self-renew and generate multiple types of differentiated daughters. Self-renewal is reflected by their capacity to undergo multiple/limitless divisions. Several signaling pathways are involved in self-renewal of stem cells, that is, Notch, Wnt, and Hedgehog pathways or Polycomb family proteins. Recent studies mainly focus on cancer stem cell (CSCs), induced pluripotent stem cell (iPSCs), neural stem cell and maintenance of embryonic stem cell pluripotency. Among them, CSCs have been believed to be responsible for tumor initiation, growth, and recurrence that have implications for cancer therapy.
MCE owns a unique collection of 2,931 compounds that can be used for stem cell regulatory and signaling pathway research.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
