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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
39 Results for "
Mixed Lineage Kinase
" in MedChemExpress (MCE) Product Catalog:
Products (39)
39 Results for "Mixed Lineage Kinase" in MCE Product Catalog:
Cat. No.: HY-P811716A
Synonyms: hMLKL ; Mixed Lineage Kinase domain like; Mixed Lineage Kinase domain like protein; Mixed Lineage Kinase domain like pseudoKinase
Cat. No.: HY-P705851
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MLKL; FLJ34389; Mixed Lineage Kinase Domain Like PseudoKinase; HMLKL; Mixed Lineage Kinase Domain-Like Protein; Mixed Lineage Kinase Domain-Like
Species:
Human
Source:
sf9 insect cells
Cat. No.: HY-P705605
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MAP3K9; MEKK9; Prev. MLK1; Mitogen-Activated Protein Kinase Kinase Kinase; PRKE1; Mixed Lineage Kinase 1; Mitogen-Activated Protein Kinase Kinase Kinase 9; Mixed Lineage Kinase 1 (Tyr And Ser/Thr Specificity)
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P705995
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAP3K9; MEKK9; Prev. MLK1; Mitogen-Activated Protein Kinase Kinase Kinase; PRKE1; Mixed Lineage Kinase 1; Mitogen-Activated Protein Kinase Kinase Kinase 9; Mixed Lineage Kinase 1 (Tyr And Ser/Thr Specificity)
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P810809
Synonyms: LZK, MAP3K13, Mitogen-activated protein Kinase Kinase Kinase 13, Leucine zipper-bearing Kinase, Mixed Lineage Kinase, MLK
Cat. No.: HY-101524R
CAS No.: 2093393-05-4
Research Areas:
TC13172 (Standard) is the analytical standard of TC13172 (HY-101524). This product is intended for research and analytical applications. TC13172 is a mixed lineage kinase domain-like protein (MLKL) inhibitor with an EC50 value of 2 nM for HT-29 cells .
Cat. No.: HY-111351R
CAS No.: 1627729-62-7
Research Areas:
MLK-IN-1 (Standard) is the analytical standard of MLK-IN-1 (HY-111351). This product is intended for research and analytical applications. MLK-IN-1 is a potent, brain penetrant and specific mixed lineage Kinase 3 (MLK-3) inhibitor, compound 68, extracted from patent US20140256733A1 .
Cat. No.: HY-P83492A
Synonyms: MAP3K11; MLK3; PTK1; SPRK; Mitogen-activated protein Kinase Kinase Kinase 11; Mixed Lineage Kinase 3; Src-homology 3 domain-containing proline-rich Kinase
Cat. No.: HY-182344
Research Areas:
MLKL ligand-2 is a mixed lineage kinase domain-like pseudokinase (MLKL) PROTAC ligand with a KD of 9.408 μM. MLKL ligand-2 forms hydrogen bond networks and hydrophobic interactions with specific MLKL residues, and stabilizes MLKL in hepatic cells. MLKL ligand-2 can be used to synthesize PROTAC MLKL Degrader-3 (HY-182343) .
Cat. No.: HY-P703370
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MAP3K21; KIAA1804; Mitogen-Activated Protein Kinase Kinase Kinase 21; Mitogen-Activated Protein Kinase Kinase Kinase MLK4; MLK4; DJ862P8.3; Mixed Lineage Kinase 4
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P705606
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAP3K10; MEKK10; Prev. MLK2; Protein Kinase MST; MST; MKN28 Kinase; Mixed Lineage Kinase 2; Mitogen-Activated Protein Kinase Kinase Kinase 10; MKN28 Derived Nonreceptor_type Serine/Threonine Kinase
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P706067
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: MAP3K10; MEKK10; Prev. MLK2; Protein Kinase MST; MST; MKN28 Kinase; Mixed Lineage Kinase 2; Mitogen-Activated Protein Kinase Kinase Kinase 10; MKN28 Derived Nonreceptor_type Serine/Threonine Kinase
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P702929
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: MAP3K11; Src-Homology 3 Domain-Containing Proline-Rich Kinase; Prev. MLK3; SH3 Domain-Containing Proline-Rich Kinase; Prev. PTK1; Protein-Tyrosine Kinase PTK1; SPRK; MLK-3; MEKK11; Mitogen-Activated Protein Kinase Kinase Kinase 11; Mixed Lineage Kinase 3
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-182343
Target:
Research Areas:
PROTAC MLKL Degrader-3 is a MLKL PROTAC degrader with DC50 values of 248.9 nM (Hepa1-6) and 271.3 nM (HepG2), respectively. PROTAC MLKL Degrader-3 induces proteasome- and cereblon-dependent MLKL degradation via ubiquitination. PROTAC MLKL Degrader-3 reduces intratumoral MLKL levels and inhibits tumor growth in mice. PROTAC MLKL Degrader-3 can be used in the research of hepatocellular carcinoma .
Cat. No.: HY-111970
CAS No.: 869796-50-9
Target:
Research Areas:
SAR113945 is a highly selective IKK-β inhibitor with an IC50 value of 0.4 nM. SAR113945 blocks the canonical NFκB signaling pathway. SAR113945 alleviates hyperalgesia to heat and mechanical stimuli, and exerts effects in a zymosan-induced knee joint inflammation model. SAR113945 is applicable to research related to symptomatic knee osteoarthritis .
Cat. No.: HY-111970B
CAS No.: 899418-65-6
Target:
Research Areas:
SAR113945 monopotassium is a highly selective IKK-β inhibitor with an IC50 value of 0.4 nM. SAR113945 monopotassium blocks the canonical NFκB signaling pathway. SAR113945 monopotassium alleviates hyperalgesia to heat and mechanical stimuli, and exerts effects in a zymosan-induced knee joint inflammation model. SAR113945 monopotassium is applicable to research related to symptomatic knee osteoarthritis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
