869796-50-9
Chemical Structure
SAR113945
- CAS No.: 869796-50-9
- Formula:C28H25N7O3
- Molecular Weight:507.55
IUPAC Name: (S)-2-(2-(2-(methylamino)pyrimidin-4-yl)-1H-indole-5-carboxamido)-3-(phenyl(pyridin-2-yl)amino)propanoic acid
InChIKey: ICBAJJBPHLBVEN-DEOSSOPVSA-N
SMILES: N(C[C@H](NC(=O)C=1C=C2C(=CC1)NC(=C2)C3=NC(NC)=NC=C3)C(O)=O)(C4=CC=CC=C4)C5=CC=CC=N5
Biological Activity: SAR113945 is a highly selective IKK-β inhibitor with an IC50 value of 0.4 nM. SAR113945 blocks the canonical NFκB signaling pathway. SAR113945 alleviates hyperalgesia to heat and mechanical stimuli, and exerts effects in a zymosan-induced knee joint inflammation model. SAR113945 is applicable to research related to symptomatic knee osteoarthritis[1][2][3].
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SAR113945 | SAR113945 is a highly selective IKK-β inhibitor with an IC50 value of 0.4 nM. SAR113945 blocks the canonical NFκB signaling pathway. SAR113945 alleviates hyperalgesia to heat and mechanical stimuli, and exerts effects in a zymosan-induced knee joint inflammation model. SAR113945 is applicable to research related to symptomatic knee osteoarthritis. | |||||||||||||||||||||
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- [1]. Grothe K, et al. IκB kinase inhibition as a potential treatment of osteoarthritis - results of a clinical proof-of-concept study. Osteoarthritis Cartilage. 2017 Jan;25(1):46-52. [Content Brief]
- [2]. Liu D, et al. Small molecule inhibitors of osteoarthritis: Current development and future perspective. Frontiers in physiology. 2023;14:1156913. [Content Brief]
- [3]. Noha SM, et al. Discovery of a novel IKK-β inhibitor by ligand-based virtual screening techniques. Bioorganic & medicinal chemistry letters. 2011 Jan 01;21(1):577-83. [Content Brief]
Keywords
