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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
45 Results for "
SCD-1
" in MedChemExpress (MCE) Product Catalog:
Products (45)
45 Results for "SCD-1" in MCE Product Catalog:
Cat. No.: HY-100249R
CAS No.: 1072803-08-7
Research Areas:
XEN723 (Standard) is the analytical standard of XEN723 (HY-100249). This product is intended for research and analytical applications. XEN723 is a novel and potent thiazolylimidazolidinone inhibitor of Stearoyl-CoA Desaturase (SCD1) with IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively.
Cat. No.: HY-189199
CAS No.: 3093981-26-8
Research Areas:
SARS-CoV-2-IN-124 is an antiviral compound. SARS-CoV-2-IN-124 directly binds to NCOA1 and promotes its lysosome-dependent degradation. SARS-CoV-2-IN-124 downregulates the expression of lipogenic enzymes FASN and SCD1. SARS-CoV-2-IN-124 inhibits SARS-CoV-2 replication in multiple cell lines. SARS-CoV-2-IN-124 can be used for research related to SARS-CoV-2 infection [1].
Cat. No.: HY-15823R
CAS No.: 944808-88-2
Research Areas:
CAY10566 (Standard) is the analytical standard of CAY10566 (HY-15823). This product is intended for research and analytical applications. CAY10566 is a potent, orally bioavailable and selective stearoyl-CoA desaturase1 (SCD1) inhibitor with IC50s of 4.5 and 26 nM in mouse and human enzymatic assays, respectively.
CAY10566 also shows excellent cellular activity in blocKing the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 cells (IC50=7.9 nM or 6.8 nM) [1] .
Cat. No.: HY-182046
CAS No.: 2930131-74-9
Research Areas:
HD202A is an orally active, selective dual inhibitor of MNK1/MNK2 (with IC50 values of 6.09 nM and 8.06 nM, and Kd values of 1.913 μM and 5.244 μM, respectively) that inhibits the MNK-eIF4E signaling pathway. By downregulating perilipin 2 and SCD1, while upregulating adipose triglyceride lipase and PPARγ coactivator 1α, HD202A enhances mitochondrial fatty acid oxidation and redox homeostasis. HD202A effectively suppresses body weight gain, hepatic lipid accumulation and elevation of serum lipids, significantly improves glucose tolerance and insulin sensitivity of the organism, and ameliorates inflammatory features. With these comprehensive pharmacological activities, HD202A exhibits great application potential in studies of metabolic dysfunction-associated steatotic liver disease [1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
