Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
58 Results for "
VCAM1
" in MedChemExpress (MCE) Product Catalog:
Products (58)
58 Results for "VCAM1" in MCE Product Catalog:
Cat. No.: HY-P705108
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: VCAM1; Vascular Cell Adhesion Molecule 1; Vascular Cell Adhesion Protein 1; CD106; CD106 Antigen; INCAM-100; V-CAM 1; VCAM-1
Species:
Human
Source:
HEK293
Category:
Flavonols other families Flavonoids Phenols Polyphenols Plants
Target:
Cat. No.: HY-187596
CAS No.: 133669-72-4
Target:
Research Areas:
Sjc 13 is an inhibitor of E-selectin and VCAM-1, with IC50 values of 150 μg/mL and 115 μg/mL, respectively. Sjc 13 prevents neutrophil migration and adhesion by selectively inhibiting the expression and mRNA synthesis of E-selectin and VCAM-1 in LPS-stimulated endothelial cells, thereby protecting against LPS-induced lethal shock. Sjc 13 is applicable to the study of septic shock [1] .
Cat. No.: HY-P704202
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: VCAM1; Vascular Cell Adhesion Molecule 1; Vascular Cell Adhesion Protein 1; CD106; CD106 Antigen; INCAM-100; V-CAM 1; VCAM-1
Species:
Cynomolgus
Source:
HEK293
Cat. No.: HY-112868A
CAS No.: 222638-65-5
Target:
Research Areas:
Cardiovascular Disease Metabolic Disease Inflammation/Immunology
ABH is an orally active arginase inhibitor (Ki = 8.5 nM). ABH promotes NO production and reduces the expression of inflammatory response-related molecules (ICAM-1, VCAM-1, MCP-1). ABH improves erectile function, reduces lung damage, promotes wound healing, reduces arterial blood pressure, and improves vascular fibrosis [1] .
Cat. No.: HY-135876
CAS No.: 29873-99-2
Synonyms: (-)-γ-Elemene
Cat. No.: HY-183516
CAS No.: 19220-35-0
Synonyms: OPG
Target:
Research Areas:
Osteoprotegerin (OPG) belongs to the tumor necrosis factor receptor (TNFR) superfamily . Osteoprotegerin blocks the RANKL-RANK interaction as well as the binding of TRAIL to its receptor. Osteoprotegerin activates NF-κB to induce the expression of ICAM-1, VCAM-1 and E-selectin, and activates the phosphorylation of ERK1/2. Osteoprotegerin regulates osteoclast activity, inhibits osteoclast maturation and formation, bone lysis and bone resorption, and increases bone mass. Osteoprotegerin regulates vascular endothelial cell function. Osteoprotegerin can be used in the research of cardio-cerebrovascular and bone-related diseases [1].
Cat. No.: HY-171216
CAS No.: 278598-52-0
Target:
Research Areas:
GW559090 is a selective, competitive, and high-affinity α4 integrin antagonist with a Kd of 0.19 nM for α4β1. GW559090 can effectively block the binding of α4β1 to vascular cell adhesion molecule 1 (VCAM-1) and fibronectin with IC50 values of 7.72 and 8.04 nM. GW559090 also inhibits the interaction between α4β7 and mucosal addressin cell adhesion molecule 1 (MAdCAM-1) (IC50 = 23 nM). GW559090 can inhibit inflammatory infiltration in the eyes, repair the corneal barrier and restore the function of goblet cells. GW559090 can be used for research of Sjögren's syndrome associated dry eye [1].
Cat. No.: HY-183448
CAS No.: 117666-86-1
Research Areas:
ETMTC is an orally active anti-inflammatory and antioxidant agent. ETMTC inhibits IKK-mediated phosphorylation and degradation of IkBα, blocks nuclear translocation and activation of NF-κB, and reduces the expression of ICAM-1, VCAM-1, E-selectin, Th2 cytokines and eosinophil chemokines. ETMTC abrogates neutrophil adhesion to endothelial monolayers and inhibits TNF-α-induced ROS production. ETMTC activates Nrf2, and enhances the activities of mitochondrial complex I and IV. ETMTC reduces lipid peroxidation levels, oxidative DNA damage, cytochrome c and caspase 9 activity, and decreases goblet cell metaplasia and subepithelial fibrosis. ETMTC can be used for the research of inflammatory diseases and asthma [1] .
Cat. No.: HY-P11887
CAS No.: 1174559-81-9
Research Areas:
Cat. No.: HY-136692
CAS No.: 479203-71-9
Target:
Research Areas:
HMR 1031 is a very late antigen-4 (VLA4, i.e., integrin α4β1) inhibitor, with IC50 values of 0.7 nM and 0.3 nM against VLA-4/VCAM-1 and VLA-4/fibronectin, respectively. HMR 1031 blocks allergen-induced airway responses and airway inflammation in mouse and sheep models. HMR 1031 can be used in asthma-related research [1].
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
