117666-86-1
Chemical Structure
ETMTC
- CAS No.: 117666-86-1
- Formula:C14H18O4S
- Molecular Weight:282.36
InChIKey: JUABUGKQZWXRLB-VOTSOKGWSA-N
SMILES: S=C(/C=C/C1=CC(OC)=C(C(OC)=C1)OC)OCC
Biological Activity: ETMTC is an orally active anti-inflammatory and antioxidant agent. ETMTC inhibits IKK-mediated phosphorylation and degradation of IkBα, blocks nuclear translocation and activation of NF-κB, and reduces the expression of ICAM-1, VCAM-1, E-selectin, Th2 cytokines and eosinophil chemokines. ETMTC abrogates neutrophil adhesion to endothelial monolayers and inhibits TNF-α-induced ROS production. ETMTC activates Nrf2, and enhances the activities of mitochondrial complex I and IV. ETMTC reduces lipid peroxidation levels, oxidative DNA damage, cytochrome c and caspase 9 activity, and decreases goblet cell metaplasia and subepithelial fibrosis. ETMTC can be used for the research of inflammatory diseases and asthma[1][2][3][4].
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ETMTC | ETMTC is an orally active anti-inflammatory and antioxidant agent. ETMTC inhibits IKK-mediated phosphorylation and degradation of IkBα, blocks nuclear translocation and activation of NF-κB, and reduces the expression of ICAM-1, VCAM-1, E-selectin, Th2 cytokines and eosinophil chemokines. ETMTC abrogates neutrophil adhesion to endothelial monolayers and inhibits TNF-α-induced ROS production. ETMTC activates Nrf2, and enhances the activities of mitochondrial complex I and IV. ETMTC reduces lipid peroxidation levels, oxidative DNA damage, cytochrome c and caspase 9 activity, and decreases goblet cell metaplasia and subepithelial fibrosis. ETMTC can be used for the research of inflammatory diseases and asthma. | |||||||||||||||||||||
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- [1]. Kumar S, et al. Novel natural product-based cinnamates and their thio and thiono analogs as potent inhibitors of cell adhesion molecules on human endothelial cells. European journal of medicinal chemistry. 2011 Nov;46(11):5498-511. [Content Brief]
- [2]. Kumar S, et al. Ethyl 3',4',5'-trimethoxythionocinnamate modulates NF-κB and Nrf2 transcription factors. European journal of pharmacology. 2013 Jan 30;700(1-3):32-41. [Content Brief]
- [3]. Kumar S, et al. Anti-inflammatory and antioxidant properties of Piper species: a perspective from screening to molecular mechanisms. Current topics in medicinal chemistry. 2015;15(9):886-93. [Content Brief]
- [4]. Kumar S, et al. A novel cinnamate derivative attenuates asthma features and reduces bronchial epithelial injury in mouse model. International immunopharmacology. 2013 Jan;15(1):150-9. [Content Brief]
Keywords
