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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
80 Results for "
SCD
" in MedChemExpress (MCE) Product Catalog:
Products (80)
80 Results for "SCD" in MCE Product Catalog:
Cat. No.: HY-163822
CAS No.: 2879250-73-2
Research Areas:
WIZ degrader 5 (example 41) is a molecular glue degrader for widely interspaced zinc (WIZ) finger motifs with an AC50 of 0.14 nM. WIZ degrader 5 induces the expression of fetal hemoglobin (HbF) with an EC50 of 25 nM. WIZ degrader 5 can be used in research related to hereditary blood disorders, such as sickle cell disease (SCD) and thalassemia .
Cat. No.: HY-163818
CAS No.: 2839552-69-9
Research Areas:
WIZ degrader 2 (Compound 142) is a molecular glue degrader for widely interspaced zinc (WIZ) finger motifs with an AC50 of 0.011 μM. WIZ degrader 2 induces the expression of fetal hemoglobin (HbF) with an EC50 of 0.038 μM. WIZ degrader 2 can be used in research related to hereditary blood disorders, such as sickle cell disease (SCD) and thalassemia .
Cat. No.: HY-P991465
Target:
Research Areas:
Cat. No.: HY-P991466
Target:
Research Areas:
Cat. No.: HY-P81418A
Synonyms: SCD1; FADS5; SCDOS; MSTP008
Cat. No.: HY-P702428
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SCD; Stearoyl-CoA Desaturase Opposite Strand; Prev. SCDOS; HSCD1; FADS5; Predicted Protein Of HQ0998; SCD1; Delta-9-Desaturase; Fatty Acid Desaturase; Delta-9 Desaturase; Acyl-CoA Desaturase; MSTP008; Stearoyl-CoA Desaturase (Delta-9-Desaturase); Stearoyl
Species:
Human
Source:
E. coli Cell-free
Cat. No.: HY-114606
CAS No.: 1673557-43-1
Research Areas:
SW208108 is a prodrug of dMe-SW208108, a CYP4F11-activated SCD inhibitor, with an IC50 value of 9 nM. SW208108 undergoes demethylation by CYP4F11 to form the active metabolite dMe-SW208108, thereby inhibiting enzyme function. SW208108 depletes unsaturated fatty acids, induces cytotoxicity in non-small cell lung cancer (NSCLC) cells expressing CYP4F11, and does not affect SCD activity in mouse sebocytes. SW208108 can be used in studies related to NSCLC .
Cat. No.: HY-102045R
CAS No.: 1809151-56-1
Research Areas:
T-3764518 (Standard) is the analytical standard of T-3764518 (HY-102045). This product is intended for research and analytical applications. T-3764518 is a novel and potent stearoyl coenzyme A desaturase (SCD) inhibitor with an IC50 of 4.7 nM.
Cat. No.: HY-100249R
CAS No.: 1072803-08-7
Research Areas:
XEN723 (Standard) is the analytical standard of XEN723 (HY-100249). This product is intended for research and analytical applications. XEN723 is a novel and potent thiazolylimidazolidinone inhibitor of Stearoyl-CoA Desaturase (SCD1) with IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively.
Cat. No.: HY-P705462
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Scavenger receptor cysteine-rich type 1 protein M130; Hemoglobin scavenger receptor; Soluble CD163; SCD163; CD163; M130
Species:
Human
Source:
HEK293
Cat. No.: HY-189199
CAS No.: 3093981-26-8
Research Areas:
SARS-CoV-2-IN-124 is an antiviral compound. SARS-CoV-2-IN-124 directly binds to NCOA1 and promotes its lysosome-dependent degradation. SARS-CoV-2-IN-124 downregulates the expression of lipogenic enzymes FASN and SCD1. SARS-CoV-2-IN-124 inhibits SARS-CoV-2 replication in multiple cell lines. SARS-CoV-2-IN-124 can be used for research related to SARS-CoV-2 infection .
Cat. No.: HY-15823R
CAS No.: 944808-88-2
Research Areas:
CAY10566 (Standard) is the analytical standard of CAY10566 (HY-15823). This product is intended for research and analytical applications. CAY10566 is a potent, orally bioavailable and selective stearoyl-CoA desaturase1 (SCD1) inhibitor with IC50s of 4.5 and 26 nM in mouse and human enzymatic assays, respectively.
CAY10566 also shows excellent cellular activity in blocKing the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 cells (IC50=7.9 nM or 6.8 nM) .
Cat. No.: HY-L087
3,741 compounds
Obesity is widely recognized as the largest and fastest growing public health problem and is associated with numerous chronic disorders including osteoarthritis, obstructive sleep apnea, gallstones, fatty liver disease, reproductive and gastrointestinal cancers, dyslipidemia, hypertension, type 2 diabetes, heart failure, coronary artery disease, stroke, etc. Although obesity has long been associated with serious health issues, it has only recently been regarded as a disease in the sense of being a specific target for medical therapy. Obesity may be viewed as the dysregulation of two physiological functions, appetite regulation and energy metabolism, which combine to create disordered energy balance. Consequently, developing obesity treatments that target novel pathways is a growing focus for both biopharmaceutical industries.
MCE Anti-Obesity Compound Library owns a unique collection of 3,741 compounds, which mainly target signaling pathway of controlling appetite, fatty acid metabolism and energy expenditure, etc. This library is a useful tool for discovery anti-obesity drugs.
Cat. No.: HY-182046
CAS No.: 2930131-74-9
Research Areas:
HD202A is an orally active, selective dual inhibitor of MNK1/MNK2 (with IC50 values of 6.09 nM and 8.06 nM, and Kd values of 1.913 μM and 5.244 μM, respectively) that inhibits the MNK-eIF4E signaling pathway. By downregulating perilipin 2 and SCD1, while upregulating adipose triglyceride lipase and PPARγ coactivator 1α, HD202A enhances mitochondrial fatty acid oxidation and redox homeostasis. HD202A effectively suppresses body weight gain, hepatic lipid accumulation and elevation of serum lipids, significantly improves glucose tolerance and insulin sensitivity of the organism, and ameliorates inflammatory features. With these comprehensive pharmacological activities, HD202A exhibits great application potential in studies of metabolic dysfunction-associated steatotic liver disease .
Cat. No.: HY-P72456
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD320; TCII-R; CD320 Molecule; TCN2R; TCblR; 8D6; 8D6A; FDC-Signaling Molecule 8D6; Transcobalamin Receptor; Transcobalamin 2 Receptor; CD320 Antigen; Soluble CD320; 8D6 Antigen; FDC-SM-8D6; SCD320
Species:
Human
Source:
HEK293
Cat. No.: HY-P76226
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD320; TCII-R; CD320 Molecule; TCN2R; TCblR; 8D6; 8D6A; FDC-Signaling Molecule 8D6; Transcobalamin Receptor; Transcobalamin 2 Receptor; CD320 Antigen; Soluble CD320; 8D6 Antigen; FDC-SM-8D6; SCD320
Species:
Rat
Source:
HEK293
Cat. No.: HY-P76798
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CD320; TCII-R; CD320 Molecule; TCN2R; TCblR; 8D6; 8D6A; FDC-Signaling Molecule 8D6; Transcobalamin Receptor; Transcobalamin 2 Receptor; CD320 Antigen; Soluble CD320; 8D6 Antigen; FDC-SM-8D6; SCD320
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P76797
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD320; TCII-R; CD320 Molecule; TCN2R; TCblR; 8D6; 8D6A; FDC-Signaling Molecule 8D6; Transcobalamin Receptor; Transcobalamin 2 Receptor; CD320 Antigen; Soluble CD320; 8D6 Antigen; FDC-SM-8D6; SCD320
Species:
Mouse
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
