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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
129 Results for "
pathogenesis
" in MedChemExpress (MCE) Product Catalog:
Products (129)
129 Results for "pathogenesis" in MCE Product Catalog:
Target:
Research Areas:
RORγt Inverse agonist 10 is a potent and orally bioavailable RORγt (retinoic acid receptor-related orphan nuclear receptor gamma t) inverse agonist, with an IC50 of 51 nM. RORγt is a major transcription factor of genes related to psoriasis pathogenesis such as IL-17A, IL-22, and IL-23R
Cat. No.: HY-123156
CAS No.: 60149-28-2
SC-23110 is a potent anti-acne agent. SC-23110 inhibits the growth of P. acnes, one of the organisms associated with acne, and most frequently mentioned as the organism involved in the pathogenesis of inflammatory pustules/lesions .
Cat. No.: HY-101045
CAS No.: 139047-55-5
Target:
Research Areas:
AT-112 is a ketotanserin analogue. AT-112 has hemodynamic effects. AT-112 significantly reduces portal vein branch blood flow and portal vein pressure. AT-112 can be used to study the pathogenesis of portal hypertension .
Cat. No.: HY-174763
Target:
Research Areas:
Human CCL2 mRNA encodes the human C-C motif chemokine ligand 2 (CCL2) protein. CCL2 displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis.
Cat. No.: HY-121252S
Cat. No.: HY-174639
Target:
Research Areas:
Human IL13 mRNA encodes the human interleukin 13 (IL13) protein, an immunoregulatory cytokine produced primarily by activated Th2 cells. IL13 is involved in several stages of B-cell maturation and differentiation and is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils.
Cat. No.: HY-113238F
Purity: 90.01%
Synonyms: FITC-Sulfolithocholic acid
Cat. No.: HY-157082
CAS No.: 2925912-67-8
Target:
Research Areas:
ZHSI-1 is an EV71 (Enterovirus 71) inhibitor that inhibits EV71/CVA16 replication and virus-induced pyroptosis associated with viral pathogenesis. ZHSI-1 effectively prevents EV71 infection in neonatal and young mice in animal models. ZHSI-1 can be used to study viral infections such as hand, foot and mouth disease (HFMD) .
Cat. No.: HY-B1118A
CAS No.: 227622-73-3
Synonyms: RP-14539 hemihydrate; PM-185184 hemihydrate
Secnidazole (RP-14539) hemihydrate is an orally active azole antibiotic and a imidazole mitigator of Serratia marcescens virulence. Secnidazole hemihydrate, as an analog of acylhomoserine lactones, effectively inhibits QS resulting in the attenuation of Pseudomonas aeruginosa pathogenesis. Secnidazole hemihydrate has antimicrobial activity against many anaerobic Gram-negative and Gram-positive bacterial species in vitro. Secnidazole hemihydrate can be used for the research of various diseases, such as amoebiasis and giardiasis, and bacterial vaginitis .
Cat. No.: HY-148449
CAS No.: 1402931-66-1
Research Areas:
eIF4A3-IN-15 (compound 52) is a Silvestrol (HY-13251) analogue. eIF4A3-IN-15 interferes the assembling of eIF4F translation complex with EC50s of 11, 700 and 120 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-15 can be used for the research of human cancer pathogenesis .
Cat. No.: HY-B1118S2
Synonyms: RP-14539-d4; PM-185184-d4
Cat. No.: HY-N1743
CAS No.: 376362-03-7
Category:
Metabolic Disease Phenols Polyphenols Plants Moraceae Broussonetia kazinoki Sieb. et Zucc. Disease Research Fields
Target:
Cat. No.: HY-N1836
CAS No.: 33417-17-3
Synonyms: 3-Hydroxy-3-acetonyloxindole
Category:
Infection Alkaloids Acanthaceae Plants Disease Research Fields Jacobaea cannabifolia (Less.) E. Wiebe Indole Alkaloids
Target:
Cat. No.: HY-14863
CAS No.: 250384-82-8
Synonyms: CTA-018
Target:
Research Areas:
Lunacalcipol (CTA-018), as a vitamin D analogue, has a dual role in the pathogenesis of Chronic Kidney Disease (CKD), as an agonist of vitamin D receptor and an antagonist of cytochrome P450 enzyme 24-hydroxylase. Lunacalcipol binds to VDR and regulates transcriptional activity of VDR by influencing ligand binding affinity, ligand-dependent coactivator recruitment or inhibitory factor dissociation, efficiency of ligand entry into target cells, tissue specificity and different metabolism of ligand. Lunacalcipol can be used in the study of CKD, especially Secondary Hyperparathyroidism (sHPT) .
Cat. No.: HY-103018S
Synonyms: ASN-002-d4
Target:
Research Areas:
Simetryn (Standard) is the analytical standard of Simetryn (HY-B1853). This product is intended for research and analytical applications. Simetryn is a triazine herbicide that exerts teratogenicity. Simetryn inhibits photosynthesis by blocking electron transfer in the chloroplast photosystem II and activates the MEK/Erk signaling pathway. Simetryn triggers vascular and developmental abnormalities in zebrafish and tadpoles, suppresses proliferation, enhances apoptosis, and induces malformations. Simetryn serves as a tool to establish a zebrafish model for studying arteriovenous malformations and related pathogenesis. Simetryn controls paddy weeds and can be used for research on developmental and vascular disorders .
Cat. No.: HY-P10525
CAS No.: 167278-49-1
Target:
Research Areas:
Cat. No.: HY-B1118S3
Synonyms: RP-14539-d3; PM-185184-d3
Cat. No.: HY-P76364
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GLIPR1; GliPR 1; GLI pathogenesis Related 1; CDNA FLJ50386, Highly Similar To Glioma pathogenesis-Related Protein 1; RTVP1; Related To Testis-Specific, Vespid, And pathogenesis Proteins 1; GliPR; Testes-Specific Vespid And pathogenesis Protein 1; Glioma P
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P70359
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GLIPR1; GliPR 1; GLI pathogenesis Related 1; CDNA FLJ50386, Highly Similar To Glioma pathogenesis-Related Protein 1; RTVP1; Related To Testis-Specific, Vespid, And pathogenesis Proteins 1; GliPR; Testes-Specific Vespid And pathogenesis Protein 1; Glioma P
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
