1014-70-6
Chemical Structure
Simetryn
- CAS No.: 1014-70-6
- Formula:C8H15N5S
- Molecular Weight:213.30
IUPAC Name: N2,N4-diethyl-6-(methylthio)-1,3,5-triazine-2,4-diamine
InChIKey: MGLWZSOBALDPEK-UHFFFAOYSA-N
SMILES: CSC1=NC(NCC)=NC(NCC)=N1
Biological Activity: Simetryn is a triazine herbicide that exerts teratogenicity. Simetryn inhibits photosynthesis by blocking electron transfer in the chloroplast photosystem II and activates the MEK/Erk signaling pathway. Simetryn triggers vascular and developmental abnormalities in zebrafish and tadpoles, suppresses proliferation, enhances apoptosis, and induces malformations. Simetryn serves as a tool to establish a zebrafish model for studying arteriovenous malformations and related pathogenesis. Simetryn controls paddy weeds and can be used for research on developmental and vascular disorders[1][2].
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Simetryn | 99.75% | Simetryn is a triazine herbicide that exerts teratogenicity. Simetryn inhibits photosynthesis by blocking electron transfer in the chloroplast photosystem II and activates the MEK/Erk signaling pathway. Simetryn triggers vascular and developmental abnormalities in zebrafish and tadpoles, suppresses proliferation, enhances apoptosis, and induces malformations. Simetryn serves as a tool to establish a zebrafish model for studying arteriovenous malformations and related pathogenesis. Simetryn controls paddy weeds and can be used for research on developmental and vascular disorders. | ||||||||||||||||||||
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Simetryn (Standard) | ≥98% | Simetryn (Standard) is the analytical standard of Simetryn (HY-B1853). This product is intended for research and analytical applications. Simetryn is a triazine herbicide that exerts teratogenicity. Simetryn inhibits photosynthesis by blocking electron transfer in the chloroplast photosystem II and activates the MEK/Erk signaling pathway. Simetryn triggers vascular and developmental abnormalities in zebrafish and tadpoles, suppresses proliferation, enhances apoptosis, and induces malformations. Simetryn serves as a tool to establish a zebrafish model for studying arteriovenous malformations and related pathogenesis. Simetryn controls paddy weeds and can be used for research on developmental and vascular disorders. | ||||||||||||||||||||
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- [1]. Xiao Z, et al. Simetryn induces arteriovenous malformations in zebrafish embryos through activation of Erk signaling. Biochem Biophys Res Commun. 2026;804:153339. [Content Brief]
- [2]. Saka M, et al. Application of an amphibian (Silurana tropicalis) metamorphosis assay to the testing of the chronic toxicity of three rice paddy herbicides: simetryn, mefenacet, and thiobencarb. Ecotoxicol Environ Saf. 2013;92:135-143. [Content Brief]
Keywords
