Simazine
Based on 1 Customer Validation
Simazine is a triazine herbicide. Simazine is widely used in agriculture, potted plant and tree production. In addition, Simazine can induce the apoptosis of immune cells in the spleen of mice and inhibit the proliferation of B cells and T cells in mice.
For research use only. We do not sell to patients.
- Purity: 99.44%
- CAS No.: 122-34-9
- Formula: C7H12ClN5
- Molecular Weight:201.66
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Apoptosis Compound Library
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Biological Activity
Simazine (200-400 μM; 9-12 h) can inhibit the maturation, disrupt the spindle morphology, affect mitochondrial function, increase the level of ROS, and induce DNA damage and early apoptosis of mouse oocytes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:one-month-old healthy BALB/c mice[2]
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Dosage:0, 90, 200, or 400 mg/kg
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Administration:Oral gavage; 3 weeks
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Result:Reduced proliferation of both spleen T and B cells.
Decreased the number of spleen CD4+ T lymphocytes, while CD8+ T cells remained unchanged.
Reduced immune function, higher intracellular [Ca2+], and oxidative stress.
Induced spleen immune cells apoptosis by reducing Bcl-2, while increasing Fas and Caspase-3 level.
Chemical Information
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CAS No. 122-34-9
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Appearance Solid
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Molecular Weight 201.66
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Formula C7H12ClN5
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Color White to off-white
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SMILES
CCNC1=NC(Cl)=NC(NCC)=N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 16.67 mg/mL (82.66 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (622 KB)
- English - EN (622 KB)
- Français - FR (622 KB)
- Deutsch - DE (622 KB)
- Norwegian - NO (622 KB)
- Español - ES (622 KB)
- Swedish - SV (622 KB)
- Italian - IT (622 KB)
- Korean - KR (622 KB)
- Portuguese - PT (622 KB)
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Handling Instructions (2659 KB)
References
[1]. Shang JZ, et al. Simazine perturbs the maturational competency of mouse oocyte through inducing oxidative stress and DNA damage. Ecotoxicol Environ Saf. 2022 Jan 15;230:113105. [Content Brief]
[2]. Ren R, et al. Oral exposure to the herbicide simazine induces mouse spleen immunotoxicity and immune cell apoptosis. Toxicol Pathol. 2013 Jan;41(1):63-72. [Content Brief]
[3]. Morten T Strandberg, et al. Field Effects of Simazine at Lower Trophic Levels--A Review. ci Total Environ. 2002 Sep 16;296(1-3):117-37. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.9588 mL | 24.7942 mL | 49.5884 mL | 123.9710 mL |
| 5 mM | 0.9918 mL | 4.9588 mL | 9.9177 mL | 24.7942 mL | |
| 10 mM | 0.4959 mL | 2.4794 mL | 4.9588 mL | 12.3971 mL | |
| 15 mM | 0.3306 mL | 1.6529 mL | 3.3059 mL | 8.2647 mL | |
| 20 mM | 0.2479 mL | 1.2397 mL | 2.4794 mL | 6.1986 mL | |
| 25 mM | 0.1984 mL | 0.9918 mL | 1.9835 mL | 4.9588 mL | |
| 30 mM | 0.1653 mL | 0.8265 mL | 1.6529 mL | 4.1324 mL | |
| 40 mM | 0.1240 mL | 0.6199 mL | 1.2397 mL | 3.0993 mL | |
| 50 mM | 0.0992 mL | 0.4959 mL | 0.9918 mL | 2.4794 mL | |
| 60 mM | 0.0826 mL | 0.4132 mL | 0.8265 mL | 2.0662 mL | |
| 80 mM | 0.0620 mL | 0.3099 mL | 0.6199 mL | 1.5496 mL |
Simazine Related Classifications
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