1201 Results for "

Humanized

" in MedChemExpress (MCE) Product Catalog:
Products (1201)

1201 Results for "Humanized" in MCE Product Catalog:

Cat. No.: HY-P99339
CAS No.: 1874157-95-5
Synonyms: IMCgp100

Research Areas:  

Cancer

Tebentafusp (IMCgp100) is a bispecific fusion protein to target gp100 peptide-HLA-A*02:01 (a melanoma-associated antigen). Tebentafusp guides T cells to kill gp100-expressing tumor cells via a high affinity T-cell receptor (TCR) binding domain and an anti-CD3 T-cell engaging domain. Tebentafusp leads to inflammatory cytokines and cytolytic proteins production, resulting in the direct lysis of tumour cells .
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Cat. No.: HY-P99393
CAS No.: 1635395-25-3
Synonyms: MEDI 0562; Tavolimab

Target:  

TNF Receptor

Research Areas:  

Cancer

Tavolixizumab (MEDI 0562; Tavolimab) is a human monoclonal antibody to TNFRSF4 (TNF receptor superfamily member 4) for use in cancer immunology research .
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Cat. No.: HY-P9940
CAS No.: 1610943-06-0
Synonyms: ACE-910; RG6013

Target:  

Factor VIII

Research Areas:  

Cardiovascular Disease

Emicizumab is a bispecific monoclonal antibody that bridges activated factor IX and factor X to replace the function of missing activated factor VIII, thereby restoring hemostasis. Emicizumab can be used for hemophilia A research .
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Cat. No.: HY-P99453
CAS No.: 1826819-57-1

Target:  

ADC Antibodies

Research Areas:  

Cancer

Azintuxizumab is an anti-SLAMF7 human IgG4κ monoclonal antibody. Azintuxizumab can be used in the synthesis of antibody-drug conjugate (ADC), Azintuxizumab vedotin .
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Cat. No.: HY-P99455
CAS No.: 2437210-79-0
Synonyms: EMB-01

Target:  

EGFR c-Met/HGFR

Research Areas:  

Cancer

Bafisontamab (EMB-01) is a bispecific antibody targeting EGFR and cMET with antitumor activity .
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Cat. No.: HY-P99470
CAS No.: 2109730-69-8
Synonyms: GEN1029

Target:  

TNF Receptor Apoptosis

Research Areas:  

Cancer

Benufutamab (GEN1029) is a death receptor 5 (DR5)-specific agonistic antibody. Benufutamab is a mixture of 2 noncompeting DR5-specific IgG1 antibodies, each with an E430G mutation in the Fc domain. Benufutamab has antitumor effects .
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Cat. No.: HY-P99481
CAS No.: 1608108-91-3
Synonyms: NEOD001

Target:  

Amyloid-β

Research Areas:  

Neurological Disease

Birtamimab (NEOD001) is an investigational monoclonal antibody that specifically and selectively target and clear the amyloid. Birtamimab can be used for the research of light chain amyloidosis .
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Cat. No.: HY-P99563
CAS No.: 1849636-24-3
Synonyms: LY 3090106

Research Areas:  

Inflammation/Immunology

Tibulizumab (LY 3090106) is a tetravalent bispecific monoclonal antibody targeting B-cell activating factor (BAFF) and IL-17A with Kd values of 60 pM and 14 pM, respectively. Tibulizumab can be used for autoimmune disease research .
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Cat. No.: HY-P99572
CAS No.: 2253891-70-0
Synonyms: BNT-312; DuoBody-CD40x-4-1BB; GEN1042

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology Cancer

Tecaginlimab (BNT-312) is a Fc-inert bispecific antibody for dual targeting and conditional stimulation of CD40 and 4-1BB. Tecaginlimab can enhance priming and reactivation of tumor-specific immunity .
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Cat. No.: HY-P99618
CAS No.: 2377419-89-9
Synonyms: IBI-315; BH2950

Target:  

EGFR PD-1/PD-L1

Research Areas:  

Cancer

Fidasimtamab is a bispecific antibody targeting human epidermal growth factor receptor 2 (Her2) and programmed death protein 1 (PD-1), with a Ka of 3.55e-10 M for human Her2 and a Ka of 1.17e-9 M for human PD-1. Fidasimtamab cross-links Her2-positive tumor cells with PD-1-positive T cells to form immune synapses, blocks PD-1-ligand interactions, preserves antibody-dependent cellular cytotoxicity, induces gasdermin B (GSDMB)-mediated pyroptosis, and activates T cells. Fidasimtamab is applicable to relevant research on Her2-positive gastric cancer .
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Cat. No.: HY-P99619
CAS No.: 2350298-85-8
Synonyms: SCT-I10A

Target:  

PD-1/PD-L1

Research Areas:  

Cancer

Finotonlimab (SCT-I10A) is a recombinant humanised IgG PD-1 antibody. Finotonlimab has the potential for solid tumors or lymphomas research .
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Cat. No.: HY-P99623
CAS No.: 1664355-28-5
Synonyms: MGD006; S80880

Target:  

CD3

Research Areas:  

Cancer

Flotetuzumab (MGD006; S80880) is an investigational CD123/CD3 bispecific dual-affinity retargeting antibody (DART) molecule. Flotetuzumab reactivates T cells by simultaneously binding to CD123 in target cells and CD3 in effector T cells, leading to T-cell-mediated cytotoxicity in target cells. Flotetuzumab shows inhibitory effect on a mouse model of patient-derived xenograft (PDX) in acute myeloid leukemia (AML) .
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Cat. No.: HY-P99640
CAS No.: 2226292-20-0
Synonyms: ABBV-927

Target:  

Inhibitory Antibodies

Research Areas:  

Cancer

Giloralimab (ABBV-927) is a potent antiCD40 agonistic monoclonal antibody. Giloralimab has the potential for the research of cancer .
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Cat. No.: HY-P99652
CAS No.: 2428381-52-4
Synonyms: AK 111

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Gumokimab (AK 111) is a monoclonal antibody targeting IL-17A, which can be used in the study of psoriasis, ankylosing spondylitis. Gumokimab competitively blocks the binding of human IL-17A to IL-17R.
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Cat. No.: HY-P99668
CAS No.: 2417649-33-1

Target:  

PD-1/PD-L1

Research Areas:  

Cancer

Iparomlimab is an anti-human PD-1/CD279/PDCD1 IgG4κ antibody. Iparomlimab also targets to human monoclonal PSB103 γ4-chain, disulfided with human monoclonal PSB103 κ-chain to form a dimer. Iparomlimab can be used for Oncology research .
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Cat. No.: HY-P99671
CAS No.: 2254082-79-4
Synonyms: M-6495

Target:  

ADAMTS

Research Areas:  

Inflammation/Immunology

Isecarosmab (M-6495) is an anti-ADAMTS monoclonal antibody (mAb) with a KD value of 3.65 pM. Isecarosmab has chondroprotective and anti-inflammatory activities. Isecarosmab can bind albumin to extend plasma half-life .
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Cat. No.: HY-P99674
CAS No.: 2364496-42-2
Synonyms: GEN-3009

Research Areas:  

Cancer

Ivicentamab (GEN-3009) is a bispecific antibody targeting CD37 with dual epitopes. Ivicentamab carries an E430G mutation in the Fc region, which efficiently promotes IgG hexamer formation on the surface of target cells. Ivicentamab provides the parental variable regions for an H429F-engineered anti-CD37 bispecific antibody, enabling it to exert complement-dependent cytotoxicity in Daudi lymphoma cells. Ivicentamab is mainly used in lymphoma-related research .
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Cat. No.: HY-P99694
CAS No.: 2396411-71-3
Synonyms: JR-171

Target:  

Transferrin Receptor

Research Areas:  

Neurological Disease

Lepunafusp alfa (JR-171) is a BBB-penetrable fusion protein consisting of J-Brain Cargo and IDUA (a lysosomal enzyme, α-L-iduronidase). Lepunafusp alfa can reduce concentration of heparan sulfate (HS) and dermatan sulfate (DS). Lepunafusp alfa can be used for research of mucopolysaccharidosis type I .
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Cat. No.: HY-P99708
CAS No.: 2412004-88-5
Synonyms: ABBV-151; ARGX-115

Target:  

TGF-beta/Smad

Research Areas:  

Cancer

Livmoniplimab (ABBV-151) is a monoclonal antibody against GARP/TGF-β1 that can inhibit the release of active TGF-β1. Livmoniplimab has anti-tumor activity in colon cancer mice. Livmoniplimab can be used for the study of locally advanced or metastatic solid tumors .
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Cat. No.: HY-P99714
CAS No.: 2416595-46-3
Synonyms: MGD019

Target:  

PD-1/PD-L1 CTLA-4

Research Areas:  

Cancer

Lorigerlimab (MGD019) is a bispecific IgG4 dual-affinity re-targeting antibody (DART). Lorigerlimab can block PD-1 and CTLA-4, and improves T-cell responses. Lorigerlimab can be used for research of metastatic castration-resistant prostate cancer (mCRPC) .
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