1874157-95-5
1874157-95-5
Chemical Structure
Tebentafusp
Synonym(s): IMCgp100
- CAS No.: 1874157-95-5
- Formula:N/A
- Molecular Weight:(76.16 kDa)
IUPAC Name: cyclopentan-1-d-1-amine hydrochloride
SMILES: [Tebentafusp]
Biological Activity: Tebentafusp (IMCgp100) is a bispecific fusion protein to target gp100 peptide-HLA-A*02:01 (a melanoma-associated antigen). Tebentafusp guides T cells to kill gp100-expressing tumor cells via a high affinity T-cell receptor (TCR) binding domain and an anti-CD3 T-cell engaging domain. Tebentafusp leads to inflammatory cytokines and cytolytic proteins production, resulting in the direct lysis of tumour cells[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Tebentafusp | 99.90% | Tebentafusp (IMCgp100) is a bispecific fusion protein to target gp100 peptide-HLA-A*02:01 (a melanoma-associated antigen). Tebentafusp guides T cells to kill gp100-expressing tumor cells via a high affinity T-cell receptor (TCR) binding domain and an anti-CD3 T-cell engaging domain. Tebentafusp leads to inflammatory cytokines and cytolytic proteins production, resulting in the direct lysis of tumour cells. | ||||||||||||||||||||
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References
- [1]. Middleton MR, et al. Tebentafusp, A TCR/Anti-CD3 Bispecific Fusion Protein Targeting gp100, Potently Activated Antitumor Immune Responses in Patients with Metastatic Melanoma. Clin Cancer Res. 2020 Nov 15;26(22):5869-5878. [Content Brief]
- [2]. Dhillon S. Tebentafusp: First Approval. Drugs. 2022 Apr;82(6):703-710. [Content Brief]
