2254082-79-4
2254082-79-4
Chemical Structure
Isecarosmab
Synonym(s): M-6495
- CAS No.: 2254082-79-4
- Formula:N/A
- Molecular Weight:(28.89 kDa)
IUPAC Name: tert-butyl 5-methyl-4-oxo-3,4-dihydropyridine-1(2H)-carboxylate
SMILES: [Isecarosmab]
Biological Activity: Isecarosmab (M-6495) is an anti-ADAMTS monoclonal antibody (mAb) with a KD value of 3.65 pM. Isecarosmab has chondroprotective and anti-inflammatory activities. Isecarosmab can bind albumin to extend plasma half-life[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Isecarosmab | 96.95% | Isecarosmab (M-6495) is an anti-ADAMTS monoclonal antibody (mAb) with a KD value of 3.65 pM. Isecarosmab has chondroprotective and anti-inflammatory activities. Isecarosmab can bind albumin to extend plasma half-life. | ||||||||||||||||||||
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References
- [1]. Siebuhr AS, et al. The Anti-ADAMTS-5 Nanobody® M6495 Protects Cartilage Degradation Ex Vivo. Int J Mol Sci. 2020 Aug 20;21(17):5992. [Content Brief]
- [2]. Sharma N, et al. Inflammation and joint destruction may be linked to the generation of cartilage metabolites of ADAMTS-5 through activation of toll-like receptors. Osteoarthritis Cartilage. 2020 May;28(5):658-668. [Content Brief]
- [3]. C. Brenneis. Structural and symptomatic benefit of a half-live extended, systemically applied anti-ADAMTS-5 inhibitor (M6495). 2018. 26 (1), S299-S300.
Keywords
