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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
261 Results for "
membrane function
" in MedChemExpress (MCE) Product Catalog:
Products (261)
261 Results for "membrane function" in MCE Product Catalog:
Cat. No.: HY-108191
CAS No.: 101411-70-5
Synonyms: Antibiotic 273a1α
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Cat. No.: HY-134406
CAS No.: 94200-58-5
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6-Cl-cPuMP (sodium) is a cAMP analog with active chlorine function. 6-Cl-cPuMP (sodium) has good membrane permeability and phosphodiesterase (PDE) stability. 6-Cl-cPuMP (sodium) can be used for nervous system research .
Cat. No.: HY-155769
Antimicrobial agent-24 (compound E8) is a hydrazide compound with excellent and broad-spectrum fungicidal activities. Antimicrobial agent-24 affects the normal function of the plasma membrane, further generating changes in the morphology and subcellular structure of mycelia .
Cat. No.: HY-W989120
CAS No.: 29428-96-4
Cat. No.: HY-P10594
CAS No.: 143244-89-7
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Cat. No.: HY-179287
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SDH-IN-42 (Compound D28) is a SDH (IC50: 5.38 μg/mL) inhibitor and antifungal agent. SDH-IN-42 exerts antifungal activity against R. solani by disrupting mycelial morphology, increasing cell membrane permeability, inducing the production and accumulation of ROS, and impairing mitochondrial function .
Cat. No.: HY-W286362
CAS No.: 6832-98-0
Synonyms: Palmitic acid anilide
Palmitanilide (Palmitic acid anilide) is an antibacterial agent against Gram-positive bacteria. Palmitanilide can electrostatically bind to relevant components in the cell walls of Gram-positive bacteria (such as Bacillus cereus), alter the cell membrane structure, and affect the normal functions of the cells. Palmitanilide is promising for research of infectious diseases caused by Gram-positive bacteria .
Cat. No.: HY-W923366
CAS No.: 119110-38-2
Synonyms: ETH 4030
Magnesium ionophore III (ETH 4030) is an ionophore that has the activity of regulating the intracellular magnesium concentration. Magnesium ionophore III can promote the permeability of cell membranes to magnesium ions and enhance cell functions and metabolic activities. Magnesium ionophore III is also used to study the importance of magnesium ions in biological processes and its effects on cell physiology.
Cat. No.: HY-10655AR
CAS No.: 2469274-58-4
Synonyms: ACT-058362 hydrochloride (Standard)
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Palosuran (hydrochloride) (Standard) is the analytical standard of Palosuran (hydrochloride). This product is intended for research and analytical applications. Palosuran hydrochloride (ACT-058362 hydrochloride) is a potent, selective, and orally active antagonist of urotensin II receptor, with an IC50 of 3.6 nM for CHO cell membranes expressing human recombinant receptors. Palosuran hydrochloride can improves pancreatic and renal function in diabetic rats .
Cat. No.: HY-10655R
CAS No.: 540769-28-6
Synonyms: ACT-058362 (Standard)
Research Areas:
Palosuran (Standard) is the analytical standard of Palosuran. This product is intended for research and analytical applications. Palosuran (ACT-058362) is a potent, selective, and orally active antagonist of urotensin II receptor, with an IC50 of 3.6 nM for CHO cell membranes expressing human recombinant receptors. Palosuran can improves pancreatic and renal function in diabetic rats .
Cat. No.: HY-W014118R
CAS No.: 101-86-0
Cat. No.: HY-184209
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Antifungal agent-163 is an antifungal agent. Antifungal agent-163 inhibits the activity of coenzyme Q-cytochrome C reductase (CoQ-Ccr), thereby disrupting electron transport in the mitochondrial respiratory chain. Antifungal agent-163 induces intracellular ROS accumulation, causes cell membrane damage, and impairs mitochondrial function in *Sublineola* cells. Antifungal agent-163 exhibits control effects against fungal plant diseases. Antifungal agent-163 can be used in the research of sorghum anthracnose .
Cat. No.: HY-L149
7,999 compounds
A membrane protein is a protein molecule that is attached to or associated with the membrane of a cell or an organelle. Membrane proteins can be classified into two groups based on how the protein is associated with the membrane: integral membrane proteins and peripheral membrane proteins. In humans, about 30% genome encodes membrane proteins. Membrane proteins perform a variety of functions vital to the survival of organisms, for example, signal transduction, molecules or ion transportation, enzymatic catalysis, and intercellular communication. Membrane proteins also play important roles in drug discovery. As reported, more than 60% of current drug targets are membrane proteins.
MCE supplies a unique collection of 7,999 compounds targeting a variety of membrane proteins. MCE Membrane Protein-targeted Compound Library can be used for membrane protein-focused screening and drug discovery.
Cat. No.: HY-L144
1,112 compounds
Normal mitochondrial function is critical for maintaining cellular homeostasis because mitochondria produce ATP and are the major intracellular source of free radicals. Cellular dysfunctions induced by intracellular or extracellular insults converge on mitochondria and induce a sudden increase in permeability on the inner mitochondrial membrane, the so-called mitochondrial membrane permeability transition (MMPT). MMPT is caused by the opening of pores in the inner mitochondrial membrane, matrix swelling, and outer membrane rupture. The MMPT is an endpoint to initiate cell death because the pore opening together with the release of mitochondrial cytochrome c activates the apoptotic pathway of caspases.
The normal operation of mitochondrial function is important for maintaining normal cell death and treatment of mitochondrial diseases. MCE offers a unique collection of 1,112 compounds with identified and potential mitochondrial protective activity. MCE Mitochondrial Protection Compound Library is critical for drug discovery and development.
Cat. No.: HY-W040171
CAS No.: 79538-32-2
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Tefluthrin is a pyrethroid insecticide. Tefluthrin prolongs the opening time of Nav1.6 sodium channels, leading to membrane depolarization and conductance block in the insect nervous system, thereby disrupting neural function .
Cat. No.: HY-P11744
CAS No.: 503474-42-8
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Cat. No.: HY-165180
CAS No.: 70005-46-8
Synonyms: Psychosine 3′-O-sulfate sodium; Psychosine 3′-sulfate sodium
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Lyso-sulfatide (bovine) sodium is a phospholipid component derived from sphingolipid catabolism and a potent factor Xa inhibitor and anticoagulant. Lyso-sulfatide (bovine) sodium binds directly to factor Xa and inhibits prothrombin activation mediated by the prothrombinase complex, thereby prolonging factor Xa-induced plasma clotting time and suppressing thrombin generation. Lyso-sulfatide (bovine) sodium serves as a reliable lipid membrane mimic for studying cell membrane structure, function, and molecular interactions .
Cat. No.: HY-189069
Antifungal agent 176 is an antifungal agent. Antifungal agent 176 disrupts the cell wall and cell membrane integrity of Phomopsis sp., leading to electrolyte leakage and malondialdehyde accumulation. Antifungal agent 176 induces dissipation of mitochondrial membrane potential in Phomopsis sp., indicating impaired mitochondrial function. Antifungal agent 176 exhibits protective efficacy against kiwifruit soft rot caused by Phomopsis sp. Antifungal agent 176 can be used in studies related to Phomopsis sp. infections such as kiwifruit soft rot .
Cat. No.: HY-167813
CAS No.: 85405-05-6
Cat. No.: HY-D3093
CAS No.: 2757682-02-1
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NRERcl is a Golgi-targeting lipid order probe. NRERcl can be used for imaging the lipid order and polarity of the endoplasmic reticulum. NRERcl carries a propyl chloride targeting group that directs it to the endoplasmic reticulum, and it functions via excited-state charge transfer, emitting colors according to local polarity changes associated with lipid order. NRERcl partitions into lipid membranes, with a higher fluorescence quantum yield in membrane environments than in aqueous buffers; its excitation wavelength is 520 nm, and the emission maximum varies with the environment (Ex/Em = 520/584-653 nm) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
