79538-32-2
Chemical Structure
Tefluthrin
- CAS No.: 79538-32-2
- Formula:C17H14ClF7O2
- Molecular Weight:418.73
IUPAC Name: 2,3,5,6-tetrafluoro-4-methylbenzyl (1S,3S)-3-((Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropane-1-carboxylate
InChIKey: ZFHGXWPMULPQSE-SZGBIDFHSA-N
SMILES: O=C(OCC1=C(C(F)=C(C(F)=C1F)C)F)[C@@H]2C(C)([C@@H]2/C=C(C(F)(F)F)\Cl)C
Biological Activity: Tefluthrin is a pyrethroid insecticide with developmental toxicity. Tefluthrin modifies the Nav1.6 voltage-gated sodium channel, prolonging Nav1.6 channel inactivation and deactivation in HEK293 cells. Tefluthrin reduces L-type Ca2+ currents, inhibits K+ outward currents, and enhances spontaneous/oscillatory action currents. Tefluthrin induces oxidative stress in rat models, causing damage to blood, immune, and nucleic acid metabolism, chromosomal aberrations, and sperm malformations; it induces oxidative stress and p53‑caspase‑3 pathway apoptosis in zebrafish models, leading to cardiac-skeletal developmental malformations such as pericardial edema, spinal curvature, and decreased skeletal mineralization. Tefluthrin can be used for pest control and research on diseases such as neurodegenerative diseases[1][2][3][4][5][6].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Tefluthrin | 98.12% | Tefluthrin is a pyrethroid insecticide with developmental toxicity. Tefluthrin modifies the Nav1.6 voltage-gated sodium channel, prolonging Nav1.6 channel inactivation and deactivation in HEK293 cells. Tefluthrin reduces L-type Ca2+ currents, inhibits K+ outward currents, and enhances spontaneous/oscillatory action currents. Tefluthrin induces oxidative stress in rat models, causing damage to blood, immune, and nucleic acid metabolism, chromosomal aberrations, and sperm malformations; it induces oxidative stress and p53‑caspase‑3 pathway apoptosis in zebrafish models, leading to cardiac-skeletal developmental malformations such as pericardial edema, spinal curvature, and decreased skeletal mineralization. Tefluthrin can be used for pest control and research on diseases such as neurodegenerative diseases. | ||||||||||||||||||||
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Tefluthrin-d5 | Tefluthrin-d5 is the deuterated-labeled Tefluthrin (HY-W040171). Tefluthrin is a pyrethroid insecticide with developmental toxicity. Tefluthrin modifies the Nav1.6 voltage-gated sodium channel, prolonging Nav1.6 channel inactivation and deactivation in HEK293 cells. Tefluthrin reduces L-type Ca2+ currents, inhibits K+ outward currents, and enhances spontaneous/oscillatory action currents. Tefluthrin induces oxidative stress in rat models, causing damage to blood, immune, and nucleic acid metabolism, chromosomal aberrations, and sperm malformations; it induces oxidative stress and p53‑caspase‑3 pathway apoptosis in zebrafish models, leading to cardiac-skeletal developmental malformations such as pericardial edema, spinal curvature, and decreased skeletal mineralization. Tefluthrin can be used for pest control and research on diseases such as neurodegenerative diseases. | |||||||||||||||||||||
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References
- [1]. Wu AZ, et al. Ventricular arrhythmias evoked by tefluthrin, a pyrethroid, at longer pacing cycle lengths in mice hearts. Circulation. 2016 Nov 11;134(suppl_1):A15870-.
- [2]. Maximiliano JE, et al. Dopaminergic and serotoninergic systems as preferential targets of the pyrethroid tefluthrin exposure in the rat brain. Environmental research. 2024 Apr 15;247:118239.
- [3]. Wu Y, et al. Effects of tefluthrin exposure on early life stages in zebrafish: Insights into cardiac and skeletal development, oxidative stress and apoptosis. Ecotoxicology and environmental safety. 2025 Mar 01;292:117931.
- [4]. Wu SN, et al. Underlying mechanism of actions of tefluthrin, a pyrethroid insecticide, on voltage-gated ion currents and on action currents in pituitary tumor (GH3) cells and GnRH-secreting (GT1-7) neurons. Toxicology. 2009 Apr 05;258(1):70-7.
- [5]. Salah SH, et al. Modulatory effect of vitamins A, C and E mixtures against tefluthrin pesticide genotoxicity in rats. Pesticide biochemistry and physiology. 2010 Oct 1;98(2):191-7.
- [6]. He B, et al. Effects of the β1 auxiliary subunit on modification of rat Nav1. 6 sodium channels expressed in HEK293 cells by the pyrethroid insecticides tefluthrin and deltamethrin. Toxicology and applied pharmacology. 2016 Jan 15;291:58-69.
