Antifungal agent 176

Antifungal agent 176 (H2) (1.5625-100 μg/mL) potently inhibits mycelial growth of Phomopsis sp. in vitro, with an EC₅₀ value of 9.85 μg/mL^[1].
Antifungal agent 176 (1.5625-100 μg/mL) inhibits mycelial growth of Phytophthora capsici in vitro, with an EC₅₀ value of 21.5 μg/mL^[1].
Antifungal agent 176 reduces the mycelial biomass of Phomopsis sp. in liquid culture in a concentration-dependent manner^[1].
Antifungal agent 176 (50-100 μg/mL; 24 h) disrupts the mycelial structure of Phomopsis sp. in a concentration-dependent manner^[1].
Antifungal agent 176 (50-100 μg/mL; 24 h) disrupts the cell membrane integrity of Phomopsis sp. in a concentration-dependent manner, allowing propidium iodide to penetrate and stain the hyphal cell nuclei^[1].
Antifungal agent 176 (50-100 μg/mL) induces dissipation of mitochondrial membrane potential in hyphae of Phomopsis strains in a concentration-dependent manner^[1].
Antifungal agent 176 (12.5-100 μg/mL; 0-9 h) increases the cell membrane permeability of hyphae from Phomopsis strains in a concentration-dependent manner, resulting in continuous electrolyte efflux within 9 h^[1].
Antifungal agent 176 (12.5-100 μg/mL) promotes the intracellular substance leakage of hyphae of Phomopsis sp. in a concentration-dependent manner^[1].

Antifungal agent 176 (50-100 μg/mL) induces membrane lipid peroxidation in Phomopsis sp. hyphae in a concentration-dependent manner, and the malondialdehyde (MDA) content reaches 83.9 nM/g at the concentration of 100 μg/mL^[1].