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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
160 Results for "
AXL
" in MedChemExpress (MCE) Product Catalog:
Products (160)
160 Results for "AXL" in MCE Product Catalog:
Cat. No.: HY-104075
CAS No.: 1037798-41-6
Target:
Research Areas:
R916562 is an orally active and selective Axl/VEGF-R2 inhibitor with IC50s of 136 nM and 24 nM, respectively. R916562 has anti-angiogenesis and anti-metastasis .
Cat. No.: HY-15150G
CAS No.: 1037624-75-1
Synonyms: R428 (GMP); BGB324 (GMP)
Cat. No.: HY-15150S
Synonyms: R428-d8; BGB324-d8
Cat. No.: HY-P700723
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GAS6; AXSF; Prev. AXLLG; DKFZp666G247; AXL Receptor Tyrosine Kinase Ligand; FLJ34709; Growth Arrest-Specific Protein 6; GAS-6; Growth Arrest Specific 6; AXL Stimulatory Factor
Species:
Cynomolgus
Source:
HEK293
Cat. No.: HY-P70780A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GAS6; AXSF; Prev. AXLLG; DKFZp666G247; AXL Receptor Tyrosine Kinase Ligand; FLJ34709; Growth Arrest-Specific Protein 6; GAS-6; Growth Arrest Specific 6; AXL Stimulatory Factor
Species:
Human
Source:
HEK293
Target:
Research Areas:
RIPK1-IN-7 is a potent and selective RIPK1 inhibitor with a Kd of 4 nM and an enzymatic IC50 of 11 nM. RIPK1-IN-7 exhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model .
Cat. No.: HY-100509R
CAS No.: 1221713-92-3
Research Areas:
NPS-1034 (Standard) is the analytical standard of NPS-1034 (HY-100509). This product is intended for research and analytical applications. NPS-1034 is a dual inhibitor of AXL and MET with IC50s of 10.3 and 48 nM, respectively.
Target:
Research Areas:
BPI-9016M is a potent, orally active, and selective dual c-Met and AXL tyrosine kinases inhibitor. BPI-9016M suppresses tumor cell growth, migration and invasion of lung adenocarcinoma .
Cat. No.: HY-100946R
CAS No.: 1437321-24-8
Synonyms: RXDX-106 (Standard)
Research Areas:
CEP-40783 (Standard) is the analytical standard of CEP-40783 (HY-100946). This product is intended for research and analytical applications. CEP-40783 is a potent, selective and orally available inhibitor of AXL and c-Met with IC50 values of 7 nM and 12 nM, respectively.
Cat. No.: HY-W400801
CAS No.: 1457983-33-3
Synonyms: G-749 hydrochloride
Target:
Research Areas:
Denfivontinib (G-749) hydrochloride is an AXL inhibitor that has synergistic antitumor effects with the PD-1 inhibitor Pembrolizumab (HY-P9902). Denfivontinib can enhance the NOD-like receptor pathway, thereby promoting the formation of the NLRP3 inflammasome .
Cat. No.: HY-P704624
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GAS6; AXSF; Prev. AXLLG; DKFZp666G247; AXL Receptor Tyrosine Kinase Ligand; FLJ34709; Growth Arrest-Specific Protein 6; GAS-6; Growth Arrest Specific 6; AXL Stimulatory Factor
Species:
Human
Source:
HEK293
Cat. No.: HY-P704625
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: GAS6; AXSF; Prev. AXLLG; DKFZp666G247; AXL Receptor Tyrosine Kinase Ligand; FLJ34709; Growth Arrest-Specific Protein 6; GAS-6; Growth Arrest Specific 6; AXL Stimulatory Factor
Species:
Human
Source:
HEK293
Cat. No.: HY-15150C
CAS No.: 1037624-76-2
Synonyms: (R)-R428; (R)-BGB324
Target:
Research Areas:
(R)-Bemcentinib ((R)-R428) is the R-isomer of Bemcentinib (HY-15150). Bemcentinib (R428) is a selective, orally active Axl inhibitor with an IC50 of 14 nM. Bemcentinib blocks tumor metastasis and prolongs survival in metastatic breast cancer models .
Cat. No.: HY-13016S1
CAS No.: 1802168-53-1
Synonyms: XL184-d4; BMS-907351-d4
Cat. No.: HY-107145AR
CAS No.: 1394820-69-9
Research Areas:
Ningetinib (Standard) is the analytical standard of Ningetinib (HY-107145A). This product is intended for research and analytical applications. Ningetinib is a potent, orally bioavailable small molecule tyrosine Kinase inhibitor (TKi) with IC50s of 6.7, 1.9 and <1.0 nM for c-Met, VEGFR2 and Axl, respectively.
Cat. No.: HY-107145R
CAS No.: 1394820-77-9
Research Areas:
Ningetinib Tosylate (Standard) is the analytical standard of Ningetinib Tosylate (HY-107145). This product is intended for research and analytical applications. Ningetinib Tosylate is a potent, orally bioavailable small molecule tyrosine Kinase inhibitor (TKi) with IC50s of 6.7, 1.9 and <1.0 nM for c-Met, VEGFR2 and Axl, respectively.
Synonyms: XL184-d6; BMS-907351-d6
Research Areas:
UNC5293 is a MERTK-selective and potent inhibitor (Ki=190 pM). UNC5293 inhibits MERTK (IC50=0.9 nM) and is more selective over Axl, Tyro3 and Flt3. UNC5293 exhibits excellent mouse PK properties and is used for bone marrow leukemia research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
