2300982-44-7
2300982-44-7
Chemical Structure
RIPK1-IN-7
- CAS No.: 2300982-44-7
- Formula:C25H22F3N5O2
- Molecular Weight:481.47
IUPAC Name: 1-(5-(4-amino-7-ethyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)indolin-1-yl)-2-(3-(trifluoromethoxy)phenyl)ethan-1-one
InChIKey: APPXQUDJLJXULP-UHFFFAOYSA-N
SMILES: NC1=C2C(N(CC)C=C2C3=CC(CCN4C(CC5=CC=CC(OC(F)(F)F)=C5)=O)=C4C=C3)=NC=N1
Biological Activity: RIPK1-IN-7 is a potent and selective RIPK1 inhibitor with a Kd of 4 nM and an enzymatic IC50 of 11 nM. RIPK1-IN-7 exhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model[1].
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RIPK1-IN-7 | 98.56% | RIPK1-IN-7 is a potent and selective RIPK1 inhibitor with a Kd of 4 nM and an enzymatic IC50 of 11 nM. RIPK1-IN-7 exhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model. | ||||||||||||||||||||
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References
Keywords
