1. Cell Cycle/DNA Damage
  2. PERK
  3. PERK-IN-2

PERK-IN-2 

Cat. No.: HY-135220
Handling Instructions

PERK-IN-2 is a potent PERK inhibitor with an IC50 of 0.2 nM.

For research use only. We do not sell to patients.

PERK-IN-2 Chemical Structure

PERK-IN-2 Chemical Structure

CAS No. : 1337531-83-5

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Description

PERK-IN-2 is a potent PERK inhibitor with an IC50 of 0.2 nM[1].

IC50 & Target

IC50: 0.2 nM (PERK)[1]

In Vitro

PERK-IN-2 (0.03-0.3 μM; 2 hours) inhibits PERK autophosphorylation in A459 cells with IC50 value ranging from 0.03−0.1 μM[1].

Cell Viability Assay[1]

Cell Line: A459 cells
Concentration: 0.03 μM, 0.1 μM, 0.3 μM
Incubation Time: 2 hours
Result: Inhibited PERK autophosphorylation in A459 cells.
Molecular Weight

437.42

Formula

C₂₃H₁₈F₃N₅O

CAS No.

1337531-83-5

SMILES

FC1=CC(F)=C(F)C(CC(N2CCC3=C2C=CC(C4=CN(C)C5=NC=NC(N)=C54)=C3)=O)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

PERK-IN-2PERKProtein kinase R-like endoplasmic reticulum kinasePKR-like endoplasmic reticulum kinaseInhibitorinhibitorinhibit

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