1337531-83-5
1337531-83-5
Chemical Structure
PERK-IN-2
- CAS No.: 1337531-83-5
- Formula:C23H18F3N5O
- Molecular Weight:437.42
IUPAC Name: 1-(5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)indolin-1-yl)-2-(2,3,5-trifluorophenyl)ethan-1-one
InChIKey: JCUSVFKWUQBVHH-UHFFFAOYSA-N
SMILES: FC1=CC(F)=C(F)C(CC(N2CCC3=C2C=CC(C4=CN(C)C5=NC=NC(N)=C54)=C3)=O)=C1
Biological Activity: PERK-IN-2 is a potent PERK inhibitor with an IC50 of 0.2 nM[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PERK-IN-2 | 99.29% | PERK-IN-2 is a potent PERK inhibitor with an IC50 of 0.2 nM. | ||||||||||||||||||||
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References
- [1]. Axten JM , et al. Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK). J Med Chem. 2012 Aug 23;55(16):7193-207. [Content Brief]
Keywords
