2. Cell Cycle/DNA Damage
  3. PERK
  4. PERK-IN-6

PERK-IN-6 (Compound 5) is a PERK inhibitor with an IC50 of 2.5 nM.

For research use only. We do not sell to patients.

PERK-IN-6 Chemical Structure

PERK-IN-6 Chemical Structure

CAS No. : 1337532-14-5

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Based on 1 publication(s) in Google Scholar

PERK-IN-6 Related Antibodies

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Description

PERK-IN-6 (Compound 5) is a PERK inhibitor with an IC50 of 2.5 nM[1].

IC50 & Target

IC50: 2.5 nM (PERK)[1]
In Vitro

PERK-IN-6 (Compound 5) inhibits thapsigargin induced PERK autophosphorylation with an IC50 of 0.1-0.3 μΜ in A549 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PERK-IN-6 Related Antibodies
In Vivo

The rat blood clearance of PERK-IN-6 (Compound 5) is 10.5 mL/min/kg after i.v infusion in SD rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

398.46

Formula

C23H22N6O
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(CC1=NC(C)=CC=C1)N2C3=C(CC2)C=C(C4=CN(C)C5=C4C(N)=NC=N5)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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PERK-IN-6 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PERK-IN-61337532-14-5PERKProtein kinase R-like endoplasmic reticulum kinasePKR-like endoplasmic reticulum kinaseInhibitorinhibitorinhibit

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HY-153160
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