2 Results for "

HTF-919

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "HTF-919" in MCE Product Catalog:

4
4 Cited Publications
Cat. No.: HY-14153A
CAS No.: 189188-57-6
Purity:  99.90%
Synonyms: SDZ-HTF-919; HTF-919
Tegaserod maleate (SDZ-HTF-919) is an orally active serotonin receptor 4 (HTR4; 5-HT4R) agonist and a 5-HT2B receptor antagonist. Tegaserod maleate has pKis of 7.5, 8.4 and 7.0 for human recombinant 5-HT2A, 5-HT2B and 5-HT2C receptors, respectively. Tegaserod maleate causes tumor cell apoptosis, blunts PI3K/Akt/mTOR signaling and decreases S6 phosphorylation. Tegaserod maleate has anti-tumor activity and has the potential for irritable bowel syndrome (IBS) research .
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Cat. No.: HY-14153AS
Synonyms: SDZ-HTF-919-13C,d3; HTF-919-13C,d3
Tegaserod- 13C,d3 (maleate) is the 13C- and deuterium labeled Tegaserod (maleate). Tegaserod maleate is a selective 5-HT4 receptor partial agonist and a 5-HT2B receptor antagonist. Tegaserod maleate exhibits a promotile effect throughout the gastrointestinal (GI) tract .
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