2 Results for "

2-Methoxyestradiol (Standard)

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "2-Methoxyestradiol (Standard)" in MCE Product Catalog:

2-Methoxyestradiol (Standard)
2-Methoxyestradiol (Standard)
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Cat. No.: HY-12033R
CAS No.: 362-07-2
Synonyms: 2-ME2 (Standard); NSC-659853 (Standard)
Category:  

Monophenols Disease markers Endocrine diseases Phenols Endogenous metabolite Cancer Steroids

Target:  

Microtubule/Tubulin Reactive Oxygen Species (ROS) Apoptosis Autophagy Endogenous Metabolite Reference Standards

2-Methoxyestradiol (Standard) is the analytical standard of 2-Methoxyestradiol. This product is intended for research and analytical applications. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa .
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2-Methoxyestrone (Standard)
2-Methoxyestrone (Standard)
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Cat. No.: HY-113252R
CAS No.: 362-08-3
Category:  

Microorganisms Monophenols Disease markers Endocrine diseases Phenols Nervous System Disorder Endogenous metabolite Steroids

Target:  

Reference Standards Endogenous Metabolite Drug Metabolite

2-Methoxyestrone (Standard) is the analytical standard of 2-Methoxyestrone (HY-113252). This product is intended for research and analytical applications. 2-Methoxyestrone is an estrogen metabolite with antimitotic activity. 2-Methoxyestrone acts as a liver-specific prohormone that undergoes demethylation to form active 2-hydroxyestrogens, and it can also interconvert with 2-Methoxyestradiol (HY-12033) via the 17β-hydroxysteroid dehydrogenase pathway. In the presence of all-trans retinoic acid, 2-Methoxyestrone exerts a strong, concentration-dependent inhibitory effect on cell growth. 2-Methoxyestrone delays the progression of pulmonary hypertension in rats, alleviates right ventricular and pulmonary vascular remodeling, and relieves proliferative pulmonary hypertension in rats. 2-Methoxyestrone can be used in studies related to proliferative pulmonary hypertension .
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