2 Results for "

3D53

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "3D53" in MCE Product Catalog:

9
9 Cited Publications
Cat. No.: HY-106178
CAS No.: 219639-75-5
Purity:  99.98%
Synonyms: 3D53
PMX-53 (3D53) is a synthetic peptidic and a potent and orally active complement C5a receptor (CD88) antagonist with an IC50 of 20 nM. PMX-53 is also a low-affinity MrgX2 agonist that stimulates MrgX2-mediated mast cell degranulation. PMX-53 specifically binds to C5aR1 and does not bind to the second C5aR (C5L2) and C3aR. PMX-53 has anti-inflammatory, anticancer and antiatherosclerotic effects .
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Cat. No.: HY-106178D
CAS No.: 852629-88-0
Synonyms: 3D53 monoacetate
Target:  

Endogenous Metabolite

Research Areas:  

Inflammation/Immunology

PMX 53 monoacetate (3D53 monoacetate) is a potent orally active CD88 (C5aR) antagonist that inhibits C5a-induced neutrophil myeloperoxide release and chemotactic activity. PMX 53 monoacetate has an IC50 value of 20 nM against C5a-induced neutrophil myeloperoxide release. >The value is 22 nM, and the IC50 value of the chemotactic activity is 75 nM. PMX 53 monoacetate is also an agonist of MrgX2 .
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