2 Results for "

3XTg-AD mice

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "3XTg-AD mice" in MCE Product Catalog:

Cat. No.: HY-184474
Target:  

LXR PPAR

Research Areas:  

Neurological Disease

AU403 is a potent, brain-penetrant, isoform-selective LXRβ/PPARδ dual agonist (EC50 ≈ 45 nM for LXRβ and EC50 ≈ 40 nM for PPARδ). AU403 is designed to bypass LXRα-driven hepatotoxicity. AU403 significantly improves cognitive functions and reduces amyloid-β plaque burden in 3xTg-AD mice. AU403 is a promising dual-acting agonist for the research of Alzheimer’s disease .
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Cat. No.: HY-184832
CAS No.: 1246751-68-7
Synonyms: Peptide 021
Target:  

Amyloid-β Tau Protein

Research Areas:  

Neurological Disease

P021 (Peptide 021) is an orally active, blood-brain barrier penetrant neurotrophic/neurogenic pentapeptide derived from the most active region of ciliary neurotrophic factor (CNTF). P021 competitively inhibits leukemia inhibitory factor (LIF) and promotes BDNF transcription. P021 targets neurogenesis and synaptic plasticity. P021 prevents neurodegeneration, Amyloid-β pathology, tau protein pathology and cognitive deficits, rescues episodic memory impairment and reduces mortality in 3xTg-AD mice. P021 is applicable to the research of Alzheimer's disease .
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