1 Result for "

AG494

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "AG494" in MCE Product Catalog:

Cat. No.: HY-101042
CAS No.: 133550-35-3
Purity:  99.31%
Synonyms: Tyrphostin AG 494
Target:  

EGFR CDK

Research Areas:  

Cancer

AG-494 (Tyrphostin AG 494) is a potent and selective EGFR tyrosine kinase inhibitor (IC50=0.7 μM). AG-494 inhibits the autophosphorylation of EGFR, ErbB2, HER1-2 and PDGF-R with IC50s 1.1, 39, 45 and 6 μM, respectively. AG-494 blocks Cdk2 activation and inhibits EGF-dependent DNA synthesis .
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