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Isoforms Recommended:	AMPKα

Results for "

AMPKα

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acetyl-CoA Carboxylase (2) Acyltransferase (1) Akt (4) AMPK (16) Apoptosis (5) Autophagy (1) Bacterial (1) Bcl-2 Family (1) Carnitine Palmitoyltransferase (CPT) (1) Caspase (1) Cholinesterase (ChE) (3) Environmental Pollutants (1) ERK (2) Fatty Acid Synthase (FASN) (2) Fungal (1) GSK-3 (1) Insecticide (3) Interleukin Related (1) Isotope-Labeled Compounds (1) JNK (2) MDM-2/p53 (1) mTOR (3) NF-κB (1) Nuclear Factor of activated T Cells (NFAT) (1) Nuclear Hormone Receptor 4A/NR4A (1) p38 MAPK (1) Parasite (2) Phospholipase (3) PI3K (4) PKA (1) PPAR (2) Reactive Oxygen Species (ROS) (1) Reference Standards (4) SOD (3) Stearoyl-CoA Desaturase (SCD) (1) TNF Receptor (1) Wnt (2)
By Research Areas:	Cancer (8) Cardiovascular Disease (3) Endocrinology (2) Infection (4) Inflammation/Immunology (4) Metabolic Disease (9) Neurological Disease (3)

By Targets:

Acetyl-CoA Carboxylase (2)

Acyltransferase (1)

Akt (4)

AMPK (16)

Apoptosis (5)

Autophagy (1)

Bacterial (1)

Bcl-2 Family (1)

Carnitine Palmitoyltransferase (CPT) (1)

Caspase (1)

Cholinesterase (ChE) (3)

Environmental Pollutants (1)

ERK (2)

Fatty Acid Synthase (FASN) (2)

Fungal (1)

GSK-3 (1)

Insecticide (3)

Interleukin Related (1)

Isotope-Labeled Compounds (1)

JNK (2)

MDM-2/p53 (1)

mTOR (3)

NF-κB (1)

Nuclear Factor of activated T Cells (NFAT) (1)

Nuclear Hormone Receptor 4A/NR4A (1)

p38 MAPK (1)

Parasite (2)

Phospholipase (3)

PI3K (4)

PKA (1)

PPAR (2)

Reactive Oxygen Species (ROS) (1)

Reference Standards (4)

SOD (3)

Stearoyl-CoA Desaturase (SCD) (1)

TNF Receptor (1)

Wnt (2)

By Research Areas:

Cancer (8)

Cardiovascular Disease (3)

Endocrinology (2)

Infection (4)

Inflammation/Immunology (4)

Metabolic Disease (9)

Neurological Disease (3)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N1411

Platycodin D 5+ Cited Publications	AMPK Wnt	Metabolic Disease
Platycodin D is a saponin isolated from Platycodon grandiflorus, acts as an activator of *AMPKα, with anti-obesity property. WNT/β-catenin* pathway mediates the anti-adipogenic effect of platycodin D .

HY-W592871

10-Hydroxy-2-decenoic acid 10-HDA; Queen Bee Acid	mTOR Apoptosis ERK MDM-2/p53 GSK-3 AMPK Interleukin Related TNF Receptor Caspase NF-κB Bacterial Fungal	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
10-Hydroxy-2-decenoic acid (10-HDA) is an orally active unsaturated medium-chain fatty acid with various physiological activities. 10-Hydroxy-2-decenoic acid induces ROS-mediated apoptosis in A549 cells. 10-Hydroxy-2-decenoic acid inhibits VEGF-induced angiogenesis in human venous endothelial cells. 10-Hydroxy-2-decenoic acid alleviates non-alcoholic fatty liver disease (NAFLD) by activating the *AMPK-α signaling pathway. 10-Hydroxy-2-decenoic acid protects against bone loss by inhibiting NF-κB* signaling downstream of FFAR4. 10-Hydroxy-2-decenoic acid is an antibiotic against many bacteria and fungi, such as Neurospora sitophila, molds and Staphylococcus aureus. 10-Hydroxy-2-decenoic acid has longevity-promoting effects in C. elegans. 10-Hydroxy-2-decenoic acid prevents osteoarthritis by targeting aspartyl β hydroxylase and inhibiting chondrocyte senescence .

HY-18555

TMPA 3 Publications Verification	Nuclear Hormone Receptor 4A/NR4A AMPK	Metabolic Disease Inflammation/Immunology Cancer
TMPA is a high-affinity Nur77 antagonist that binds to Nur77 leading to the release and shuttling of LKB1 in the cytoplasm to activate *AMPKα*. TMPA effectively lowers blood glucose and attenuates insulin resistance in type II db/db, high-fat diet and streptozotocin-induced diabetic mice. TMPA reduces RICD (restimulation-induced cell death) in human T cells, can also be used in studies of cancer and T-cell apoptosis dysregulation .

HY-B1885

Fenitrothion 2 Publications Verification	Environmental Pollutants Apoptosis Insecticide Cholinesterase (ChE) AMPK PI3K Parasite Akt SOD	Infection
Fenitrothion is a broad-spectrum and orally active insecticide/acaricide. Fenitrothion inhibits cholinesterase, *AMPKα* and IRS1/PI3K/AKT. Fenitrothion causes Apoptosis, reduces SOD activity. Fenitrothion shows insecticidal effect against Rhyzopertha dominica and Tribolium castaneum adults. Fenitrothion is widely used in cotton crops, vegetable crops, fruit crops and field crops, especially rice. Fenitrothion can be used for brain and spleen toxicology studies .

HY-N0853A

Alisol A 24-acetate 1 Publications Verification Alisol A 24-monoacetate; Alisol A monoacetate	AMPK Carnitine Palmitoyltransferase (CPT) Acyltransferase Fatty Acid Synthase (FASN) Acetyl-CoA Carboxylase Bcl-2 Family PPAR Nuclear Factor of activated T Cells (NFAT) PI3K Akt PKA ERK Apoptosis Autophagy	Cardiovascular Disease Infection Neurological Disease Metabolic Disease Endocrinology
Alisol A 24-acetate (Alisol A monoacetate) is an orally active derivative of protostane-type tetracyclic triterpenoid. Alisol A 24-acetate upregulates the expression of adiponectin, *AMPKα, CPT1, and ACOX1; downregulates the expression of SREBP-1c, ACC, FAS, Bcl-2, Bcl-xl, PPAR-γ, perilipin A, and NFATc1; inhibits the activity of PI3K/Akt/mTOR* and HMGR; and activates the PKA and ERK signaling pathways. Alisol A 24-acetate regulates cell apoptosis (apoptosis), autophagy (Autophagy, hepatic lipid accumulation, inflammatory response, neuroprotection, MRSA membrane integrity, and osteoclast differentiation. Alisol A 24-acetate can be used in research related to non-alcoholic fatty liver disease, nephrotoxicity, obesity, global cerebral ischemia-reperfusion injury, bacterial infection, and osteoporosis .

HY-163649

A17	AMPK	Metabolic Disease
A17 is a bile acid analog with anti-non-alcoholic steatohepatitis (NASH) and anti-inflammatory activities. A17 reduces fatty acid (FA) uptake and promotes FA oxidation though inhibiting fatty acid translocase (Cd36) expression and activating *AMPKα*. A17 can be used for NASH research .

HY-19415

SB-435495	Phospholipase	Metabolic Disease
SB-435495 is a potent, selective, reversible, non-covalent and orally active Lp-PLA₂ inhibitor with an IC₅₀ of 0.06 nM .

HY-E70648

AMPK alpha 1 Recombinant Human Active Protein Kinase	AMPK	Cancer
AMPK is an αβγ heterotrimeric serinethreonine kinase activated by decreasing concentrations of adenosine triphosphate (ATP) and increasing AMP concentrations. AMPK alpha 1 Recombinant Human Active Protein Kinase is obtained by co-expressing AMPKα1 proteins .

HY-19415B

SB-435495 ditartrate	Phospholipase	Metabolic Disease
SB-435495 ditartrate is a potent, selective, reversible, non-covalent and orally active Lp-PLA₂ inhibitor with an IC₅₀ of 0.06 nM .

HY-N7521

Procyanidin C2 Procyanidine C2	Acetyl-CoA Carboxylase Fatty Acid Synthase (FASN) Stearoyl-CoA Desaturase (SCD) PPAR AMPK mTOR JNK	Inflammation/Immunology
Procyanidin C2 (Procyanidine C2) is a lipid metabolism regulator and antioxidant with free radical scavenging activity. Procyanidin C2 down-regulates ACC, SREBP-1c, FAS, SCD-1 and PPARγ. Procyanidin C2 increases the level of phosphorylated *AMPKα* and inhibits the level of phosphorylated mTOR. Procyanidin C2 reduces lipid accumulation, alleviates oxidative stress, enhances fatty acid oxidation and improves mitochondrial function. Procyanidin C2 can be used in the research of non-alcoholic fatty liver disease .

HY-E70793

*Biotin-AMPKα1β1γ1 Recombinant Human Active Protein Kinase*	AMPK	Cancer
AMPK is an αβγ heterotrimeric serinethreonine kinase activated by decreasing concentrations of adenosine triphosphate (ATP) and increasing AMP concentrations. Biotin-AMPKα1β1γ1 Recombinant Human Active Protein Kinase is obtained by co-expressing AMPKα1, AMPKβ1, and AMPKγ1 proteins and is biotinylated .

HY-N1411R

Platycodin D (Standard)	Reference Standards AMPK Wnt	Metabolic Disease
Platycodin D (Standard) is the analytical standard of Platycodin D. This product is intended for research and analytical applications. Platycodin D is a saponin isolated from Platycodon grandiflorus, acts as an activator of AMPKα, with anti-obesity property. WNT/β-catenin pathway mediates the anti-adipogenic effect of platycodin D .

HY-111431R

p-Cresyl sulfate (Standard) p-Tolyl sulfate (Standard)	Reference Standards JNK p38 MAPK Reactive Oxygen Species (ROS)	Metabolic Disease
Platycodin D (Standard) is the analytical standard of Platycodin D. This product is intended for research and analytical applications. Platycodin D is a saponin isolated from Platycodon grandiflorus, acts as an activator of AMPKα, with anti-obesity property. WNT/β-catenin pathway mediates the anti-adipogenic effect of platycodin D .

HY-W592871R

10-Hydroxy-2-decenoic acid (Standard) 10-HDA (Standard); Queen Bee Acid (Standard)	Reference Standards mTOR	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
10-Hydroxy-2-decenoic acid (Standard) is an analytical standard for 10-Hydroxy-2-decenoic acid (HY-W592871). This product is intended for research and analytical applications.10-Hydroxy-2-decenoic acid (10-HDA) is an orally active unsaturated medium-chain fatty acid with various physiological activities. 10-Hydroxy-2-decenoic acid induces ROS-mediated apoptosis in A549 cells. 10-Hydroxy-2-decenoic acid inhibits VEGF-induced angiogenesis in human venous endothelial cells. 10-Hydroxy-2-decenoic acid alleviates non-alcoholic fatty liver disease (NAFLD) by activating the *AMPK-α signaling pathway. 10-Hydroxy-2-decenoic acid protects against bone loss by inhibiting NF-κB* signaling downstream of FFAR4. 10-Hydroxy-2-decenoic acid is an antibiotic against many bacteria and fungi, such as Neurospora sitophila, molds and Staphylococcus aureus. 10-Hydroxy-2-decenoic acid has longevity-promoting effects in C. elegans. 10-Hydroxy-2-decenoic acid prevents osteoarthritis by targeting aspartyl β hydroxylase and inhibiting chondrocyte senescence .

HY-E70796

*Biotin-AMPKα2β1γ1 Recombinant Human Active Protein Kinase*	AMPK	Cancer
AMPK is an αβγ heterotrimeric serinethreonine kinase activated by decreasing concentrations of adenosine triphosphate (ATP) and increasing AMP concentrations. Biotin-AMPKα2β1γ1 Recombinant Human Active Protein Kinase is obtained by co-expressing AMPKα2, AMPKβ1, and AMPKγ1 proteins and is biotinylated .

HY-E70795

*Biotin-AMPKα1β2γ1 Recombinant Human Active Protein Kinase*	AMPK	Cancer
AMPK is an αβγ heterotrimeric serinethreonine kinase activated by decreasing concentrations of adenosine triphosphate (ATP) and increasing AMP concentrations. Biotin-AMPKα1β2γ1 Recombinant Human Active Protein Kinase is obtained by co-expressing AMPKα1, AMPKβ2, and AMPKγ1 proteins and is biotinylated .

HY-19415A

SB-435495 hydrochloride	Phospholipase	Metabolic Disease
SB-435495 hydrochloride is a potent, selective, reversible, non-covalent and orally active Lp-PLA₂ inhibitor with an IC₅₀ of 0.06 nM .

HY-B1885S

Fenitrothion-d6	Isotope-Labeled Compounds Insecticide Cholinesterase (ChE) AMPK PI3K Akt Apoptosis SOD	Infection
Fenitrothion-d₆ is the deuterium labeled Fenitrothion (HY-B1885). Fenitrothion is a broad-spectrum and orally active insecticide/acaricide. Fenitrothion inhibits cholinesterase, *AMPKα* and IRS1/PI3K/AKT. Fenitrothion causes Apoptosis, reduces SOD activity. Fenitrothion shows insecticidal effect against Rhyzopertha dominica and Tribolium castaneum adults. Fenitrothion is widely used in cotton crops, vegetable crops, fruit crops and field crops, especially rice. Fenitrothion can be used for brain and spleen toxicology studies .

HY-B1885R

Fenitrothion (Standard)	Reference Standards Insecticide Parasite Cholinesterase (ChE) AMPK PI3K Akt Apoptosis SOD	Infection
Fenitrothion (Standard) is the analytical standard of Fenitrothion (HY-B1885). This product is intended for research and analytical applications. Fenitrothion is a broad-spectrum and orally active insecticide/acaricide. Fenitrothion inhibits cholinesterase, *AMPKα* and IRS1/PI3K/AKT. Fenitrothion causes Apoptosis, reduces SOD activity. Fenitrothion shows insecticidal effect against Rhyzopertha dominica and Tribolium castaneum adults. Fenitrothion is widely used in cotton crops, vegetable crops, fruit crops and field crops, especially rice. Fenitrothion can be used for brain and spleen toxicology studies .

HY-181077

AMPKα1 activator 1	AMPK	Endocrinology
AMPKα1 activator 1 is a selective and orally active AMPKα1 activator with an EC₅₀ of 35.1 nM. AMPKα1 activator 1 shows 176-fold selectivity over AMPKα2. AMPKα1 activator 1 can be used as a cell protectant and a kidney protectant. AMPKα1 activator 1 attenuates elevation of serum creatinine and blood urea nitrogen levels, alleviates kidney damage, and reduces cellular infiltration in renal ischemia-reperfusion injury contexts. AMPKα1 activator 1 can be associated with renal ischemia-reperfusion injury research .

HY-E70794

*Biotin-AMPKα1β1γ2 Recombinant Human Active Protein Kinase*	AMPK	Cancer
AMPK is an αβγ heterotrimeric serinethreonine kinase activated by decreasing concentrations of adenosine triphosphate (ATP) and increasing AMP concentrations. Biotin-AMPKα1β1γ2 Recombinant Human Active Protein Kinase is obtained by co-expressing AMPKα1, AMPKβ1, and AMPKγ2 proteins and is biotinylated .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1411

Platycodin D 5+ Cited Publications	Triterpenes Human Gut Microbiota Metabolites Classification of Application Fields Terpenoids Platycodon grandiflorus (Jacq.) A. DC. Campanulaceae Metabolic Disease Plants Endogenous metabolite Disease Research Fields Source Classification	AMPK Wnt
Platycodin D is a saponin isolated from Platycodon grandiflorus, acts as an activator of *AMPKα, with anti-obesity property. WNT/β-catenin* pathway mediates the anti-adipogenic effect of platycodin D .

HY-W592871

10-Hydroxy-2-decenoic acid 10-HDA; Queen Bee Acid	Animals Ketones, Aldehydes, Acids Source Classification	mTOR Apoptosis ERK MDM-2/p53 GSK-3 AMPK Interleukin Related TNF Receptor Caspase NF-κB Bacterial Fungal
10-Hydroxy-2-decenoic acid (10-HDA) is an orally active unsaturated medium-chain fatty acid with various physiological activities. 10-Hydroxy-2-decenoic acid induces ROS-mediated apoptosis in A549 cells. 10-Hydroxy-2-decenoic acid inhibits VEGF-induced angiogenesis in human venous endothelial cells. 10-Hydroxy-2-decenoic acid alleviates non-alcoholic fatty liver disease (NAFLD) by activating the *AMPK-α signaling pathway. 10-Hydroxy-2-decenoic acid protects against bone loss by inhibiting NF-κB* signaling downstream of FFAR4. 10-Hydroxy-2-decenoic acid is an antibiotic against many bacteria and fungi, such as Neurospora sitophila, molds and Staphylococcus aureus. 10-Hydroxy-2-decenoic acid has longevity-promoting effects in C. elegans. 10-Hydroxy-2-decenoic acid prevents osteoarthritis by targeting aspartyl β hydroxylase and inhibiting chondrocyte senescence .

HY-N0853A

Alisol A 24-acetate 1 Publications Verification Alisol A 24-monoacetate; Alisol A monoacetate	Triterpenes Structural Classification Alisma plantago-aquatica Linn. Classification of Application Fields Terpenoids Other Diseases Alismataceae Plants Disease Research Fields Source Classification	AMPK Carnitine Palmitoyltransferase (CPT) Acyltransferase Fatty Acid Synthase (FASN) Acetyl-CoA Carboxylase Bcl-2 Family PPAR Nuclear Factor of activated T Cells (NFAT) PI3K Akt PKA ERK Apoptosis Autophagy
Alisol A 24-acetate (Alisol A monoacetate) is an orally active derivative of protostane-type tetracyclic triterpenoid. Alisol A 24-acetate upregulates the expression of adiponectin, *AMPKα, CPT1, and ACOX1; downregulates the expression of SREBP-1c, ACC, FAS, Bcl-2, Bcl-xl, PPAR-γ, perilipin A, and NFATc1; inhibits the activity of PI3K/Akt/mTOR* and HMGR; and activates the PKA and ERK signaling pathways. Alisol A 24-acetate regulates cell apoptosis (apoptosis), autophagy (Autophagy, hepatic lipid accumulation, inflammatory response, neuroprotection, MRSA membrane integrity, and osteoclast differentiation. Alisol A 24-acetate can be used in research related to non-alcoholic fatty liver disease, nephrotoxicity, obesity, global cerebral ischemia-reperfusion injury, bacterial infection, and osteoporosis .

HY-N7521

Procyanidin C2 Procyanidine C2	Structural Classification Polygonaceae Phenols Polyphenols Fagopyrum dibotrys (D. Don) Hara Plants Source Classification	Acetyl-CoA Carboxylase Fatty Acid Synthase (FASN) Stearoyl-CoA Desaturase (SCD) PPAR AMPK mTOR JNK
Procyanidin C2 (Procyanidine C2) is a lipid metabolism regulator and antioxidant with free radical scavenging activity. Procyanidin C2 down-regulates ACC, SREBP-1c, FAS, SCD-1 and PPARγ. Procyanidin C2 increases the level of phosphorylated *AMPKα* and inhibits the level of phosphorylated mTOR. Procyanidin C2 reduces lipid accumulation, alleviates oxidative stress, enhances fatty acid oxidation and improves mitochondrial function. Procyanidin C2 can be used in the research of non-alcoholic fatty liver disease .

HY-N1411R

Platycodin D (Standard)	Triterpenes Structural Classification Human Gut Microbiota Metabolites Terpenoids Platycodon grandiflorus (Jacq.) A. DC. Campanulaceae Plants Endogenous metabolite Source Classification	Reference Standards AMPK Wnt
Platycodin D (Standard) is the analytical standard of Platycodin D. This product is intended for research and analytical applications. Platycodin D is a saponin isolated from Platycodon grandiflorus, acts as an activator of AMPKα, with anti-obesity property. WNT/β-catenin pathway mediates the anti-adipogenic effect of platycodin D .

HY-111431R

p-Cresyl sulfate (Standard) p-Tolyl sulfate (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards JNK p38 MAPK Reactive Oxygen Species (ROS)
Platycodin D (Standard) is the analytical standard of Platycodin D. This product is intended for research and analytical applications. Platycodin D is a saponin isolated from Platycodon grandiflorus, acts as an activator of AMPKα, with anti-obesity property. WNT/β-catenin pathway mediates the anti-adipogenic effect of platycodin D .

HY-W592871R

10-Hydroxy-2-decenoic acid (Standard) 10-HDA (Standard); Queen Bee Acid (Standard)	Structural Classification Animals Ketones, Aldehydes, Acids Source Classification	Reference Standards mTOR
10-Hydroxy-2-decenoic acid (Standard) is an analytical standard for 10-Hydroxy-2-decenoic acid (HY-W592871). This product is intended for research and analytical applications.10-Hydroxy-2-decenoic acid (10-HDA) is an orally active unsaturated medium-chain fatty acid with various physiological activities. 10-Hydroxy-2-decenoic acid induces ROS-mediated apoptosis in A549 cells. 10-Hydroxy-2-decenoic acid inhibits VEGF-induced angiogenesis in human venous endothelial cells. 10-Hydroxy-2-decenoic acid alleviates non-alcoholic fatty liver disease (NAFLD) by activating the *AMPK-α signaling pathway. 10-Hydroxy-2-decenoic acid protects against bone loss by inhibiting NF-κB* signaling downstream of FFAR4. 10-Hydroxy-2-decenoic acid is an antibiotic against many bacteria and fungi, such as Neurospora sitophila, molds and Staphylococcus aureus. 10-Hydroxy-2-decenoic acid has longevity-promoting effects in C. elegans. 10-Hydroxy-2-decenoic acid prevents osteoarthritis by targeting aspartyl β hydroxylase and inhibiting chondrocyte senescence .

Cat. No.	Product Name	Chemical Structure

HY-B1885S

Fenitrothion-d6
Fenitrothion-d₆ is the deuterium labeled Fenitrothion (HY-B1885). Fenitrothion is a broad-spectrum and orally active insecticide/acaricide. Fenitrothion inhibits cholinesterase, *AMPKα* and IRS1/PI3K/AKT. Fenitrothion causes Apoptosis, reduces SOD activity. Fenitrothion shows insecticidal effect against Rhyzopertha dominica and Tribolium castaneum adults. Fenitrothion is widely used in cotton crops, vegetable crops, fruit crops and field crops, especially rice. Fenitrothion can be used for brain and spleen toxicology studies .

Fenitrothion-d6

Fenitrothion-d₆ is the deuterium labeled Fenitrothion (HY-B1885). Fenitrothion is a broad-spectrum and orally active insecticide/acaricide. Fenitrothion inhibits cholinesterase, AMPKα and IRS1/PI3K/AKT. Fenitrothion causes Apoptosis, reduces SOD activity. Fenitrothion shows insecticidal effect against Rhyzopertha dominica and Tribolium castaneum adults. Fenitrothion is widely used in cotton crops, vegetable crops, fruit crops and field crops, especially rice. Fenitrothion can be used for brain and spleen toxicology studies .

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AMPKα

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
Products