1 Result for "

AN02

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "AN02" in MCE Product Catalog:

Cat. No.: HY-179228
CAS No.: 1246964-08-8
Target:  

CTLA-4 TGF-beta/Smad

Research Areas:  

Cancer

AN02 is a derivative of Curcumin (HY-N0005). AN02 inhibits the proliferation and clonogenicity, migration and invasion of ovarian cancer cells. AN02 dose-dependently upregulates the expression of APC and mediates the degradation of CTLA-4 through SMAD4. In the small xenograft model, AN02 significantly inhibits tumor growth and reverses the tumor immune-suppressive microenvironment. AN02, when combined with Ipilimumab (HY-P9901), can enhance efficacy and inhibit epithelial-mesenchymal transition. AN02 can be used for the study of ovarian cancer .
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