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Alternaria alternata

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By Targets:	Antibiotic (1) Apoptosis (1) Bacterial (3) Endogenous Metabolite (3) Environmental Pollutants (1) Fungal (12) Herbicide (1) Mitochondrial Metabolism (1) Reactive Oxygen Species (ROS) (2) Reference Standards (1) Succinate Dehydrogenase (1)
By Research Areas:	Cancer (3) Infection (14) Metabolic Disease (1)

Inhibitors & Agonists

Biochemical Assay Reagents

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Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-119976

Boscalid 1 Publications Verification	Environmental Pollutants Apoptosis Fungal Mitochondrial Metabolism Succinate Dehydrogenase	Infection
Boscalid is a succinate dehydrogenase (SDHI) inhibitor with antifungal activity. Boscalid binds to the ubiquinone-binding site of fungal mitochondrial complex II, blocks ATP production and aerobic respiration, exhibits good control efficacy against a variety of plant fungal diseases including gray mold, sclerotinia rot and powdery mildew, and is widely used for disease control in agriculture. Boscalid induces apoptosis, altered lipid metabolism, mitochondrial dysfunction, respiratory impairment, oxidative stress, ROS accumulation and neurodevelopmental disorders in zebrafish. Boscalid reduces foraging ability, shortens median death time and causes chronic toxicity in exposed honeybees. Boscalid also possesses genotoxicity, cytotoxicity, elevated mitochondrial superoxide levels and early-stage apoptosis .

HY-P1940

Maculosin Cyclo(Tyr-Pro)	Endogenous Metabolite Bacterial Fungal	Infection Cancer
Maculosin (Cyclo (Tyr-Pro)) is a host-specific phytotoxin for spotted knapweed from Alternaria alternata. Maculosin is a quorum-sensing molecule involved in cell-cell communication. Maculosin also acts as a signaling molecule regulating virulence gene expression. Maculosin shows antimicrobial, antifungal, antioxidant and anti-cancer properties .Maculosin (Cyclo (Tyr-Pro)) is a host-specific phytotoxin for spotted knapweed from Alternaria alternata. Maculosin is a quorum-sensing molecule involved in cell-cell communication. Maculosin also acts as a signaling molecule regulating virulence gene expression. Maculosin shows antimicrobial, antifungal, antioxidant and anti-cancer properties .

HY-23155

2-Phenylethyl isothiocyanate 1 Publications Verification 2-PE ITC	Fungal	Infection
2-Phenylethyl isothiocyanate is a potent antifungal agent. 2-Phenylethyl isothiocyanate significantly inhibited spore germination and mycelial growth of Alternaria alternata, with a MIC (minimum inhibitory concentration) of 1.22 mM. The antifungal effect of 2-Phenylethyl isothiocyanate against Alternaria alternate might be via reduction in toxin content and breakdown of cell membrane integrity .

HY-N6724

Altertoxin I Dihydroalterperylenol	Others	Metabolic Disease
Altertoxin I (Dihydroalterperylenol) is a quinone-type mycotoxin produced by Alternaria alternata fungi, which is mutagenic and cytotoxic, and can weakly disrupts metabolic communication .

HY-N6783

Oligomycin C 1 Publications Verification	Fungal Antibiotic	Infection
Oligomycin C is a macrolide antibiotic produced by Streptomyces strains. Oligomycin C exhibits a strong activity against Aspergillus niger, Alternaria alternata, Botrytis cinerea and Phytophthora capsici but no activity toward bacteria .

HY-23155S

2-Phenylethyl isothiocyanate-d5 2-PE ITC-d₅	Fungal	Infection
2-Phenylethyl isothiocyanate-d₅ isothiocyanate-d₅ is the deuterium labeled 2-Phenylethyl isothiocyanate[1]. 2-Phenylethyl isothiocyanate is a potent antifungal agent. 2-Phenylethyl isothiocyanate significantly inhibited spore germination and mycelial growth of Alternaria alternata, with a MIC (minimum inhibitory concentration) of 1.22 mM. The antifungal effect of 2-Phenylethyl isothiocyanate against Alternaria alternata might be via reduction in toxin content and breakdown of cell membrane integrity[2][3].

HY-W007980

Antifungal agent 98	Fungal	Infection
Antifungal agent 98 (compound 2) is an antifungal agent. Antifungal agent 98 (100 μg/mL) shows insecticidal activity against Bipolaris sorokinianum, Fusarium oxysporium f. sp.vasinfectum, Pyricularia oryzae, Alternaria Brassicae and Alternaria alternata with a death rate of 41.5%, 40.0%, 23.4, 36.8%, and 35.0% .

HY-23155R

2-Phenylethyl isothiocyanate (Standard) 2-PE ITC (Standard)	Fungal Reference Standards	Infection
2-Phenylethyl isothiocyanate (Standard) is the analytical standard of 2-Phenylethyl isothiocyanate. This product is intended for research and analytical applications. 2-Phenylethyl isothiocyanate is a potent antifungal agent. 2-Phenylethyl isothiocyanate significantly inhibited spore germination and mycelial growth of Alternaria alternata, with a MIC (minimum inhibitory concentration) of 1.22 mM. The antifungal effect of 2-Phenylethyl isothiocyanate against Alternaria alternate might be via reduction in toxin content and breakdown of cell membrane integrity .

HY-N9714

4-Hydroxyalternariol-9-methyl ether	Others	Others
4-Hydroxyalternariol-9-methyl ether can be isolated from an endolichenic fungal strain Nigrospora sphaerica (No.83-1-1-2), endolichenic fungal strains Alternaria alternata (No.58-8-4-1) and Phialophora sp. (No.96-1-8-1) .

HY-168470

Antifungal agent 125	Fungal	Infection
Antifungal agent 125 (compound 4H) is a potent inhibitor of succinate dehydrogenase (SDH), with the IC₅₀ of 3.59 μg/mL. Antifungal agent 125 exhibits fungicidal activity against Alternaria alternata .

HY-122191

AK-Toxin II	Others	Infection
AK-Toxin II is a phytotoxic metabolite that can be isolated from culture broth of alternaria alternata Japanese pear pathotype. AK-Toxin II induces characteristic veinal necrosis and rapid K ⁺ loss on susceptible pear leaves .

HY-N12033

4'-Demethylpodophyllotoxone	Others	Cancer
4'-Demethylpodophyllotoxone is an intermediate product of the biotransformation of Alternaria alternata S-f6. After 4'-Demethylpodophyllotoxone is modified with 4-(2,3,5,6-tetramethylpyrazine-1) (4-TMP), the resulting novel compound can strongly inhibit the growth of human gastric cancer cell line (BGC-823) .

HY-N10126

(3ξ,4ξ,5ξ,6ξ,7ξ,11ξ)-3,6-Dihydroxy-8-oxo-9-eremophilene-12-oic acid	Others	Others
(3ξ,4ξ,5ξ,6ξ,7ξ,11ξ)-3,6-Dihydroxy-8-oxo-9-eremophilene-12-oic acid is a new phytotoxin of Alternaria alternata ssp. tenuissima isolates associated with fruit spots on apple.

HY-174388

Antifungal agent 134	Fungal Herbicide Reactive Oxygen Species (ROS)	Infection
Antifungal agent 134 (Compound B13) is an antifungal agent with EC₅₀s of 3.24, 1.89, 1.70, 0.36, 4.27, and 1.50 μg/mL for Botrytis cinerea, Alternaria solani, Fusarium graminearum, Rhizoctonia solani, Colletotrichum orbiculare, and Alternaria alternata, respectively. Antifungal agent 134 can disrupt the cell membrane and mitochondria of the hyphae, leading to significant ROS accumulation. Antifungal agent 134 also has significant herbicidal activities against field weeds, such as Amaranthus retroflexus L and Abutilon theophrasti Medicus. Antifungal agent 134 can be used for crop diseases and field weeds research .

HY-N9553

Alternarian acid	Endogenous Metabolite	Others
Alternarian acid is a polyketide compound found in the endophytic fungus Alternaria alternata MT-47, an endophytic fungus isolated from the medicinal plant of Huperzia serrata. Alternarian acid shows little inhibitory activity against thrombin-activated platelets, acetylcholinesterase, or butyrylcholinesterase .

HY-N7519

5-(12Z-Heptadecenyl)-resorcinol	Fungal	Infection
5-(12Z-Heptadecenyl)-resorcinol (Compound 1a) serves as the main component of Antifungal mixtures. 5-(12Z-Heptadecenyl)-resorcinol can be isolated from mango peels. Antifungal mixtures composed of 5-(12Z-Heptadecenyl)-resorcinol exhibit activity against Alternaria alternata. 5-(12Z-Heptadecenyl)-resorcinol can be used in studies related to mango fruit black spot disease .

HY-N16428

Neoaspergillic acid NSC 356436	Endogenous Metabolite Fungal Bacterial	Infection Cancer
Neoaspergillic acid (NSC 356436) (Compound 2) is a microbial secondary metabolite. Neoaspergillic acid can be isolated from the endophytic fungus Aspergillus sp. SPH2. Neoaspergillic acid has potent antifungal activity against Alternaria alternata, Botrytis cinerea and Fusarium oxysporum. Neoaspergillic acid appears during the exponential phase of fungal growth. Neoaspergillic acid also antitumor and antibacterial effects .

HY-W012475

cis-3-Hexenyl benzoate	Fungal	Infection
cis-3-Hexenyl benzoate is a volatile organic compound with a grassy aroma, widely used in the fragrance and cosmetic industries. It exhibits weak antifungal activity. cis-3-Hexenyl benzoate shows no significant risks in genotoxicity, reproductive toxicity, or environmental toxicity, and its skin sensitization potential is controllable within defined concentration limits .

HY-183792

Antibacterial agent 347	Bacterial Reactive Oxygen Species (ROS)	Infection
Antibacterial agent 347 (Compound 4d) is an Antibacterial agent. Antibacterial agent 347 exhibits selective antibacterial activity against Streptococcus mutans. Antibacterial agent 347 shows moderate ABTS• ⁺ free radical scavenging activity .

Cat. No.	Product Name	Type

HY-119976

Boscalid 1 Publications Verification	Biochemical Assay Reagents
Boscalid is a succinate dehydrogenase (SDHI) inhibitor with antifungal activity. Boscalid binds to the ubiquinone-binding site of fungal mitochondrial complex II, blocks ATP production and aerobic respiration, exhibits good control efficacy against a variety of plant fungal diseases including gray mold, sclerotinia rot and powdery mildew, and is widely used for disease control in agriculture. Boscalid induces apoptosis, altered lipid metabolism, mitochondrial dysfunction, respiratory impairment, oxidative stress, ROS accumulation and neurodevelopmental disorders in zebrafish. Boscalid reduces foraging ability, shortens median death time and causes chronic toxicity in exposed honeybees. Boscalid also possesses genotoxicity, cytotoxicity, elevated mitochondrial superoxide levels and early-stage apoptosis .

Boscalid

1 Publications Verification

Biochemical Assay Reagents

Boscalid is a succinate dehydrogenase (SDHI) inhibitor with antifungal activity. Boscalid binds to the ubiquinone-binding site of fungal mitochondrial complex II, blocks ATP production and aerobic respiration, exhibits good control efficacy against a variety of plant fungal diseases including gray mold, sclerotinia rot and powdery mildew, and is widely used for disease control in agriculture. Boscalid induces apoptosis, altered lipid metabolism, mitochondrial dysfunction, respiratory impairment, oxidative stress, ROS accumulation and neurodevelopmental disorders in zebrafish. Boscalid reduces foraging ability, shortens median death time and causes chronic toxicity in exposed honeybees. Boscalid also possesses genotoxicity, cytotoxicity, elevated mitochondrial superoxide levels and early-stage apoptosis .

Cat. No.	Product Name	Target	Research Area

HY-P1940

Maculosin Cyclo(Tyr-Pro)	Endogenous Metabolite Bacterial Fungal	Infection Cancer
Maculosin (Cyclo (Tyr-Pro)) is a host-specific phytotoxin for spotted knapweed from Alternaria alternata. Maculosin is a quorum-sensing molecule involved in cell-cell communication. Maculosin also acts as a signaling molecule regulating virulence gene expression. Maculosin shows antimicrobial, antifungal, antioxidant and anti-cancer properties .Maculosin (Cyclo (Tyr-Pro)) is a host-specific phytotoxin for spotted knapweed from Alternaria alternata. Maculosin is a quorum-sensing molecule involved in cell-cell communication. Maculosin also acts as a signaling molecule regulating virulence gene expression. Maculosin shows antimicrobial, antifungal, antioxidant and anti-cancer properties .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-P1940

Maculosin Cyclo(Tyr-Pro)	Alkaloids Monophenols Microorganisms Pyrrole Alkaloids Phenols Disease Research Fields Source Classification Cancer	Endogenous Metabolite Bacterial Fungal
Maculosin (Cyclo (Tyr-Pro)) is a host-specific phytotoxin for spotted knapweed from Alternaria alternata. Maculosin is a quorum-sensing molecule involved in cell-cell communication. Maculosin also acts as a signaling molecule regulating virulence gene expression. Maculosin shows antimicrobial, antifungal, antioxidant and anti-cancer properties .Maculosin (Cyclo (Tyr-Pro)) is a host-specific phytotoxin for spotted knapweed from Alternaria alternata. Maculosin is a quorum-sensing molecule involved in cell-cell communication. Maculosin also acts as a signaling molecule regulating virulence gene expression. Maculosin shows antimicrobial, antifungal, antioxidant and anti-cancer properties .

HY-N6724

Altertoxin I Dihydroalterperylenol	Seeds of Cassia tora Linn. Structural Classification Classification of Application Fields Metabolic Disease Plants Quinones Microorganisms other families Leguminosae Phenols Polyphenols Disease Research Fields Source Classification	Others
Altertoxin I (Dihydroalterperylenol) is a quinone-type mycotoxin produced by Alternaria alternata fungi, which is mutagenic and cytotoxic, and can weakly disrupts metabolic communication .

HY-N6783

Oligomycin C 1 Publications Verification	Infection Microorganisms Antifungal Macrolide Antibiotics Classification of Application Fields Antibiotics Disease Research Disease Research Fields Source Classification	Fungal Antibiotic
Oligomycin C is a macrolide antibiotic produced by Streptomyces strains. Oligomycin C exhibits a strong activity against Aspergillus niger, Alternaria alternata, Botrytis cinerea and Phytophthora capsici but no activity toward bacteria .

HY-N9714

4-Hydroxyalternariol-9-methyl ether	Microorganisms Phenols Polyphenols Source Classification	Others
4-Hydroxyalternariol-9-methyl ether can be isolated from an endolichenic fungal strain Nigrospora sphaerica (No.83-1-1-2), endolichenic fungal strains Alternaria alternata (No.58-8-4-1) and Phialophora sp. (No.96-1-8-1) .

HY-122191

AK-Toxin II	Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Others
AK-Toxin II is a phytotoxic metabolite that can be isolated from culture broth of alternaria alternata Japanese pear pathotype. AK-Toxin II induces characteristic veinal necrosis and rapid K ⁺ loss on susceptible pear leaves .

HY-N12033

4'-Demethylpodophyllotoxone	Podophyllum peltatum L. Lignans Phenylpropanoids Plants Berberidaceae Source Classification	Others
4'-Demethylpodophyllotoxone is an intermediate product of the biotransformation of Alternaria alternata S-f6. After 4'-Demethylpodophyllotoxone is modified with 4-(2,3,5,6-tetramethylpyrazine-1) (4-TMP), the resulting novel compound can strongly inhibit the growth of human gastric cancer cell line (BGC-823) .

HY-N10126

(3ξ,4ξ,5ξ,6ξ,7ξ,11ξ)-3,6-Dihydroxy-8-oxo-9-eremophilene-12-oic acid	Structural Classification other families Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Plants Disease Research Fields Source Classification	Others
(3ξ,4ξ,5ξ,6ξ,7ξ,11ξ)-3,6-Dihydroxy-8-oxo-9-eremophilene-12-oic acid is a new phytotoxin of Alternaria alternata ssp. tenuissima isolates associated with fruit spots on apple.

HY-N9553

Alternarian acid	Structural Classification Monophenols Microorganisms Phenols Source Classification	Endogenous Metabolite
Alternarian acid is a polyketide compound found in the endophytic fungus Alternaria alternata MT-47, an endophytic fungus isolated from the medicinal plant of Huperzia serrata. Alternarian acid shows little inhibitory activity against thrombin-activated platelets, acetylcholinesterase, or butyrylcholinesterase .

HY-N7519

5-(12Z-Heptadecenyl)-resorcinol	Structural Classification Phenols Polyphenols Mangifera indica Linn. Plants Anacardiaceae Source Classification	Fungal
5-(12Z-Heptadecenyl)-resorcinol (Compound 1a) serves as the main component of Antifungal mixtures. 5-(12Z-Heptadecenyl)-resorcinol can be isolated from mango peels. Antifungal mixtures composed of 5-(12Z-Heptadecenyl)-resorcinol exhibit activity against Alternaria alternata. 5-(12Z-Heptadecenyl)-resorcinol can be used in studies related to mango fruit black spot disease .

HY-N16428

Neoaspergillic acid NSC 356436	Natural Products Microorganisms Source Classification	Endogenous Metabolite Fungal Bacterial
Neoaspergillic acid (NSC 356436) (Compound 2) is a microbial secondary metabolite. Neoaspergillic acid can be isolated from the endophytic fungus Aspergillus sp. SPH2. Neoaspergillic acid has potent antifungal activity against Alternaria alternata, Botrytis cinerea and Fusarium oxysporum. Neoaspergillic acid appears during the exponential phase of fungal growth. Neoaspergillic acid also antitumor and antibacterial effects .

Cat. No.	Product Name	Chemical Structure

HY-23155S

2-Phenylethyl isothiocyanate-d5
2-Phenylethyl isothiocyanate-d₅ isothiocyanate-d₅ is the deuterium labeled 2-Phenylethyl isothiocyanate[1]. 2-Phenylethyl isothiocyanate is a potent antifungal agent. 2-Phenylethyl isothiocyanate significantly inhibited spore germination and mycelial growth of Alternaria alternata, with a MIC (minimum inhibitory concentration) of 1.22 mM. The antifungal effect of 2-Phenylethyl isothiocyanate against Alternaria alternata might be via reduction in toxin content and breakdown of cell membrane integrity[2][3].

2-Phenylethyl isothiocyanate-d5

2-Phenylethyl isothiocyanate-d₅ isothiocyanate-d₅ is the deuterium labeled 2-Phenylethyl isothiocyanate[1]. 2-Phenylethyl isothiocyanate is a potent antifungal agent. 2-Phenylethyl isothiocyanate significantly inhibited spore germination and mycelial growth of Alternaria alternata, with a MIC (minimum inhibitory concentration) of 1.22 mM. The antifungal effect of 2-Phenylethyl isothiocyanate against Alternaria alternata might be via reduction in toxin content and breakdown of cell membrane integrity[2][3].

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Alternaria alternata

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

NaturalProducts

Isotope-Labeled Compounds

Natural
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