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22 Results for "
Aminoacyl-tRNA Synthetase
" in MedChemExpress (MCE) Product Catalog:
Products (22)
22 Results for "Aminoacyl-tRNA Synthetase" in MCE Product Catalog:
3
3 Cited Publications
Target:
Research Areas:
Gln-AMS is an aminoacyl-tRNA synthetases (AARS) inhibitor, which binds the A-domain within the NRPS enzymes.
3
3 Cited Publications
Cat. No.: HY-112861A
Purity: 99.65%
Target:
Research Areas:
Gln-AMS (TFA) is a type Ia aminoacyl-tRNA synthetase (AARS) inhibitor. Gln-AMS inhibits glutaminyl-tRNA synthetase (GlnRS) with a Ki of 1.32 µM.
Synonyms: IleSA
Target:
Research Areas:
Aminoacyl tRNA synthetase-IN-1 (IleSA) is an inhibitor of bacterial aminoacyl-tRNA synthetase (aaRS). Aminoacyl tRNA synthetase-IN-1 is applicable to studies on bacterial infections .
Cat. No.: HY-P990782
CAS No.: 2566615-11-8
Synonyms: ATYR-1923; KRP-R120
Target:
Research Areas:
Cat. No.: HY-147643
CAS No.: 93218-59-8
Target:
Research Areas:
Aminoacyl tRNA synthetase-IN-2 (Compound 14) is an aminoacyl-tRNA synthetase (aaRS) inhibitor. Aminoacyl tRNA synthetase-IN-2 can be used for development of a new family of antibiotics .
Cat. No.: HY-117938
CAS No.: 2209057-94-1
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Research Areas:
T-3861174 is an inhibitor of prolyl-tRNA synthetase (PRS, Aminoacyl-tRNA Synthetase) without completely inhibiting its translation process. T-3861174 activates the GCN2-ATF4 pathway and induces death in multiple tumor cell lines, including SK-MEL-2. T-3861174 demonstrated significant antitumor activity in multiple xenograft models without significantly affecting body weight .
Cat. No.: HY-162238
CAS No.: 2650846-59-4
OSM-S-106 is a species-selective reaction hijacking pro-inhibitor targeting the cytosolic asparaginyl-tRNA synthetase (PfAsnRS) of Plasmodium falciparum. OSM-S-106 undergoes PfAsnRS-mediated reaction hijacking to form the Asn-OSM-S-106 adduct, which blocks the PfAsnRS catalytic cycle, inhibits protein translation, and activates the amino acid starvation response. OSM-S-106 is useful for research on malaria, PfAsnRS, and the reaction hijacking mechanism of aminoacyl-tRNA synthetases .
Cat. No.: HY-161800
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Research Areas:
Aminoacyl tRNA synthetase-IN-3 (compound 36K3) is an inhibitor of lysine tRNA synthetase (PfLysRS) from Plasmodium falciparum (IC50=59.2 nM), which inhibits the activity of PfLysRS by occupying the ATP binding site and L-lysine binding site of PfLysRS. Aminoacyl tRNA synthetase-IN-3 can be used in the development of antimalarial drugs .
Cat. No.: HY-128189
CAS No.: 342017-94-1
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Research Areas:
Aminoacyl tRNA synthetase-IN-4 (Compound 1l) is an inhibitor of Aminoacyl tRNA synthetase, with an IC50 of 0.026 μM for C.albicans prolyl-tRNA synthetase. Aminoacyl tRNA synthetase-IN-4 can be used for antifungal research .
Cat. No.: HY-108939R
CAS No.: 219931-45-0
Synonyms: IleSA (Standard)
Research Areas:
Aminoacyl tRNA synthetase-IN-1 (Standard) is the analytical standard of Aminoacyl tRNA synthetase-IN-1 (HY-108939). This product is intended for research and analytical applications. Aminoacyl tRNA synthetase-IN-1 is a bacterial aminoacyl tRNA synthetase (aaRS) inhibitor. Aminoacyl tRNA synthetase-IN-1 has inhibitory activity against S. aureus, E. faecalis and E.coli .
Cat. No.: HY-147674
CAS No.: 2494195-61-6
Target:
Research Areas:
Isoleucyl tRNA synthetase-IN-2 (compound 36a) is a potent and selective isoleucyl-tRNA synthetase (IleRS) inhibitor, with a Ki,app of 114 nM .
Cat. No.: HY-172773
PAA-38 is a highly potent selective inhibitor targeting bacterial prolyl-tRNA synthetase (ProRS). PAA-38 againsts Pseudomonas aeruginosa ProRS (PaProRS) with a Kd value of 0.399 nM and an IC50 value of 4.97 nM. PAA-38 againsts human cytoplasmic ProRSs (HsProRS) with an IC50 value of 35.5 nM. PAA-38 demonstrates an in vitro antibacterial activity of minimum inhibitory concentration (MIC) = 4-8 μg/mL .
Cat. No.: HY-130718
CAS No.: 2408626-64-0
ThrRS-IN-1 (Compound 30d) is a threonyl-tRNA synthetase (ThrRS) inhibitor with an IC50 of 1.4 µM and a Kd of 1.36 µM against Salmonella enterica ThrRS (SeThrRS). ThrRS-IN-1 simultaneously targets the tRNA Thr and L-threonine binding pockets of ThrRS. ThrRS-IN-1 shows potent antibacterial activities .
Cat. No.: HY-P76314
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: EEF1E1; Multisynthase Complex Auxiliary Component P18; Prev. P18; Elongation Factor P18; AIMP3; P18 Component Of Aminoacyl-tRNA Synthetase Complex; Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 3; ARS-Interacting Multifunctional Pr
Species:
Human
Source:
E. coli
Cat. No.: HY-147671
CAS No.: 1241942-59-5
Target:
Research Areas:
CB 168 is a potent and selective aminoacyl-sulfamoyl aryltetrazole inhibitor targeting isoleucyl-tRNA synthetase (IleRS) .
Cat. No.: HY-147672
CAS No.: 2502167-19-1
Target:
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IleRS-IN-1 (compound 11) is a potent and selective isoleucyl-tRNA synthetase (IleRS) inhibitor, with a Ki,app of 88 nM .
Cat. No.: HY-111434AR
CAS No.: 1994331-17-7
Synonyms: UAA crosslinker 1 hydrochloride (Standard)
Research Areas:
UAA crosslinker 1 hydrochloride (Standard) is the analytical standard of UAA crosslinker 1 (hydrochloride) (HY-111434A). This product is intended for research and analytical applications. UAA crosslinker 1 hydrochloride is an amber codon used for non-canonical amino acids (ncAAs) incorporation. The ncAAs can be incorporated into proteins in vivo by maKing use of the promiscuous activity of certain wildtype and engineered aminoacyl-tRNA synthetases . UAA crosslinker 1 (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Cat. No.: HY-P71538
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: AIMP2; JTV-1; Aminoacyl tRNA Synthetase Complex Interacting Multifunctional Protein 2; P38; JTV1; MultiSynthetase Complex Auxiliary Component P38; Aminoacyl tRNA Synthase Complex-Interacting Multifunctional Protein 2; PRO0992; Multisynthase Complex Auxili
Species:
Human
Source:
E. coli
Cat. No.: HY-P86767
Synonyms: Aimp2 antibody; AIMP2_HUMAN antibody; Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 antibody; Aminoacyl tRNA Synthetase complex interacting multifunctional protein 2 antibody; ARS interacting multi functional protein 2 antibody; JTV 1 antibody; JTV 1 protein antibody; JTV1 antibody; JTV1 gene antibody; Multisynthase complex auxiliary component p38 antibody; Aimp2 antibody; AIMP2_HUMAN antibody; Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 antibody; Aminoacyl tRNA Synthetase complex interacting multifunctional protein 2 antibody; ARS interacting multi functional protein 2 antibody; JTV 1 antibody; JTV 1 protein antibody; JTV1 antibody; JTV1 gene antibody; Multisynthase complex auxiliary component p38 antibody; MultiSynthetase complex auxiliary component p38 antibody; P38 antibody; PRO0992 antibody; Protein JTV 1 antibody; Protein JTV-1 antibody; tRNA Synthetase COFACTOR p38 antibody;
Cat. No.: HY-P810810
Synonyms: AIMP3, P18, EEF1E1, Eukaryotic translation elongation factor 1 epsilon-1, Aminoacyl tRNA Synthetase complex-interacting multifunctional protein 3, Elongation factor p18, Multisynthase complex auxiliary component p18
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
