1 Result for "

Anti-Mouse CD80 Antibody (TKMG48)

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "Anti-Mouse CD80 Antibody (TKMG48)" in MCE Product Catalog:

Cat. No.: HY-P992062

Target:  

PD-1/PD-L1

Research Areas:  

Inflammation/Immunology

Anti-Mouse CD80 Antibody (TKMG48) is an antibody that targets mouse CD80. By specifically binding to and disrupting the CD80:PD-L1 complex to release PD-L1, Anti-Mouse CD80 Antibody (TKMG48) functions as an indirect PD-1 agonist without blocking CD28 co-stimulation or CD80-CTLA4 binding. Anti-Mouse CD80 Antibody (TKMG48) inhibits T cell activation, reduces T cell effector functions and antigen-specific CD8 + T cell populations, and does not interfere with the differentiation, migration, antigen presentation or surface marker expression of dendritic cells. Anti-Mouse CD80 Antibody (TKMG48) significantly attenuates disease severity in mouse models of arthritis, spondyloarthritis, multiple sclerosis and Sjögren's syndrome, and its activity depends on the expression of PD-1 and PD-L1 .
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