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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
Bell's palsy
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "Bell's palsy" in MCE Product Catalog:
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Methyllycaconitine (MLA) citrate is a blood-brain barrier-permeable antagonist of α7 nicotinic acetylcholine receptor (α7nAChR) with an IC50 of 2 nM. Methyllycaconitine citrate inhibits Aβ25-35-induced autophagy by restoring the mTOR pathway, and prevents reactive oxygen species (ROS) production, microglial activation, reduced dopamine uptake, loss of dopaminergic terminals and catecholamine secretion. Methyllycaconitine citrate induces hippocampal glutamate efflux, enhances long-term potentiation, and improves memory acquisition. Methyllycaconitine citrate can be used in research related to Alzheimer's disease, cerebral palsy, Parkinson's disease and schizophrenia .
Cat. No.: HY-P99648
CAS No.: 1788032-39-2
Synonyms: BMS-986168; IPN007; BIIB092
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Cat. No.: HY-P9995
CAS No.: 2517973-04-3
Synonyms: JNJ-63733657
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HBT1 is an effective AMPA receptor AMPA-R potentiator. HBT1 specifically binds to the ligand-binding domain (LBD) of AMPAR and enhances receptor activity only when AMPA is present., HBT1 has almost no agonistic effect (i.e., reaching the optimal concentration, and then the efficacy decreases as the concentration continues to increase) compared with traditional AMPA-R potentiator, avoiding the bell-shaped reaction of brain-derived neurotrophic factor (BDNF) production in primary neurons. HBT1 can be applicable to a wider range of neurological and psychiatric diseases (such as depression, Alzheimer's disease, etc.) .
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NOS1-IN-1 is a selective and cell-permeable nNOS inhibitor with a Ki of 120 nM. NOS1-IN-1 exhibits 2617-fold and 325-fold selectivity over eNOS (Ki=39 μM) and iNOS (Ki=325 μM) , respectively . NOS1-IN-1 can be used for the research of neurological disease, including cerebral palsy (CP) .
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Triamcinolone diacetate is a synthetic derivative of glucocorticoid. Triamcinolone diacetate has anti-inflammatory activity. Triamcinolone diacetate can be used in research on dermatomyositis, Bell's palsy and rheumatoid arthritis .
Cat. No.: HY-173291
CAS No.: 3063166-64-0
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Tau ligand-1 (Compound 75) is a ligand for aggregated tau protein that can penetrate the blood-brain barrier . In tissues from patients with Alzheimer's disease, progressive supranuclear palsy, corticobasal degeneration, and Pick's disease, Tau ligand-1 exhibits high affinity for aggregated tau protein, with equilibrium dissociation constant (KD) values ranging from 1 to 3.8 nM . Tau ligand-1 can serve as a potential positron emission tomography (PET) tracer and holds promise for application in positron emission tomography imaging studies of tau-related diseases in the central nervous system .
Cat. No.: HY-P5728
CAS No.: 302343-00-6
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Cat. No.: HY-P5725
CAS No.: 1240116-47-5
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Cat. No.: HY-P991377
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Cat. No.: HY-158702
CAS No.: 40581-89-3
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5-HTQ chloride is an indole alkaloid that can be isolated from the skin secretions of the Australian golden bell frog Litoria aurea. 5-HTQ chloride is also a full agonist of the 5-HT receptor .
Cat. No.: HY-179335
CAS No.: 17806-68-7
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Cat. No.: HY-172129
CAS No.: 2636786-68-8
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HDAC6-IN-52 (EX.1) is a potent inhibitor of HDAC6, with the inhibitory rate of 100% at 10 μM. HDAC6-IN-52 plays an important role in central nervous system diseases including neurodegenerative diseases such as Alzheimer’s disease andprogressive supranuclear palsy .
Cat. No.: HY-P99648A
CAS No.: 1788032-39-2
Synonyms: BMS-986168 (powder); IPN007 (powder); BIIB092 (powder)
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Cat. No.: HY-N19726
CAS No.: 121924-06-9
Category:
Capsicum annuum L. Terpenoids Diterpenoids Plants Solanaceae
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Cat. No.: HY-181600
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O-GlcNAcase-IN-4 (compound T-110) is a O-GlcNAcase inhibitor with an IC50 of 11.59 nM. O-GlcNAcase-IN-4 modulates the activity of O-GlcNAcase. O-GlcNAcase-IN-4 is applicable to the research of neurodegenerative diseases and disorders, Alzheimer's disease, and tau-mediated neurodegenerative diseases or disorders .
Cat. No.: HY-N2332
CAS No.: 21019-30-7
Synonyms: MLA
Cat. No.: HY-185357
CAS No.: 3083792-74-6
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TAU-IN-6 (Compound 13) is a Tau protein misfolding and aggregation inhibitor. TAU-IN-6 inhibits stress granules composed of tau and TIA1. TAU-IN-6 is applicable for Alzheimer's disease research .
Cat. No.: HY-187114
CAS No.: 1841078-84-9
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3-(1H-Pyrrolo[2,3-c]pyridin-1-yl)-7-isoquinolinol is a pyrrolopyridine compound that binds to tau aggregates and β-amyloid aggregates. 3-(1H-Pyrrolo[2,3-c]pyridin-1-yl)-7-isoquinolinol serves as a positron emission tomography (PET) tracer for research related to Alzheimer's disease and other neurodegenerative diseases characterized by tau pathology .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
