3063166-64-0
Chemical Structure
Tau ligand-1
- CAS No.: 3063166-64-0
- Formula:C17H16FN3O
- Molecular Weight:297.33
InChIKey: VMFGXNQGZROBNK-UHFFFAOYSA-N
SMILES: FC1=NC(N2CCOCC2)=CC=C1C3=CC4=C(N3)C=CC=C4
Biological Activity: Tau ligand-1 (Compound 75) is a ligand for aggregated tau protein that can penetrate the blood-brain barrier[1]. In tissues from patients with Alzheimer's disease, progressive supranuclear palsy, corticobasal degeneration, and Pick's disease, Tau ligand-1 exhibits high affinity for aggregated tau protein, with equilibrium dissociation constant (KD) values ranging from 1 to 3.8 nM[1]. Tau ligand-1 can serve as a potential positron emission tomography (PET) tracer and holds promise for application in positron emission tomography imaging studies of tau-related diseases in the central nervous system[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Tau ligand-1 | 99.47% | Tau ligand-1 (Compound 75) is a ligand for aggregated tau protein that can penetrate the blood-brain barrier. In tissues from patients with Alzheimer's disease, progressive supranuclear palsy, corticobasal degeneration, and Pick's disease, Tau ligand-1 exhibits high affinity for aggregated tau protein, with equilibrium dissociation constant (KD) values ranging from 1 to 3.8 nM. Tau ligand-1 can serve as a potential positron emission tomography (PET) tracer and holds promise for application in positron emission tomography imaging studies of tau-related diseases in the central nervous system. | ||||||||||||||||||||
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