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Borealin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Caspase (1) CDK (1) Small Interfering RNA (siRNA) (2) Survivin (2)
By Research Areas:	Cancer (2)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

Inhibitors & Agonists

Peptides

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Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-RS02317

CDCA8 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CDCA8 Human Pre-designed siRNA Set A contains three designed siRNAs for CDCA8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CDCA8 Human Pre-designed siRNA Set A CDCA8 Human Pre-designed siRNA Set A

HY-RS22425

Cdca8 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cdca8 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cdca8 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cdca8 Mouse Pre-designed siRNA Set A Cdca8 Mouse Pre-designed siRNA Set A

HY-118447

RO0505124	CDK Survivin	Cancer
RO0505124 is a selective CDK4 inhibitor with an IC₅₀ of 20 nM. RO0505124 reversibly binds the ATP pocket of the kinase. RO0505124 induces G1 phase arrest in cancer cells via reduced retinoblastoma protein (Rb) phosphorylation, blocking S phase progression. RO0505124 exhibits anti-proliferative activity against various cancer cells. RO0505124 delays mitotic entry, induces aberrant mitosis with lagging chromosomes, driving mitotic slippage and formation of multinucleated or micronucleated cells. RO0505124 inhibits G2/M phase accumulation of survivin and *borealin*. RO0505124 can be used for the research of cancer .

HY-P11828

Anticancer agent 324	Survivin Caspase Apoptosis	Cancer
Anticancer agent 324 is a Survivin inhibitor. Anticancer agent 324 competitively binds to Survivin’s linker region and triggers proteasomal IAP degradation. Anticancer agent 324 blocks *Borealin* binding and chromosomal passenger complex formation, and inhibits Survivin-CRM1 nuclear-cytoplasmic transport. Anticancer agent 324 activates extrinsic (caspase-8) and intrinsic (caspase-9) apoptotic pathways, activates executioner caspases-3 and caspases-7, and arrests cell cycle. Anticancer agent 324 can be used for the research of breast cancer .

Cat. No.	Product Name	Target	Research Area

HY-P11828

Anticancer agent 324	Survivin Caspase Apoptosis	Cancer
Anticancer agent 324 is a Survivin inhibitor. Anticancer agent 324 competitively binds to Survivin’s linker region and triggers proteasomal IAP degradation. Anticancer agent 324 blocks *Borealin* binding and chromosomal passenger complex formation, and inhibits Survivin-CRM1 nuclear-cytoplasmic transport. Anticancer agent 324 activates extrinsic (caspase-8) and intrinsic (caspase-9) apoptotic pathways, activates executioner caspases-3 and caspases-7, and arrests cell cycle. Anticancer agent 324 can be used for the research of breast cancer .

Host:	Mouse (2)
Reactivity:	Human (2)
Application:	IHC-P (2)
Isotype:	IgG2a (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1)
Modification:	Unmodified (1)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P88286

	CDCA8 Antibody (YA7970) BOR; Borealin; DasraB; MESRGP	IHC-P	Human
	CDCA8 Antibody (YA7970) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to CDCA8.

HY-P88286A

	CDCA8 Antibody (YA7970)(PBS only) BOR; Borealin; DasraB; MESRGP	IHC-P	Human
	CDCA8 Antibody (YA7970) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to CDCA8.

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CDCA8 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CDCA8 Human Pre-designed siRNA Set A contains three designed siRNAs for CDCA8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cdca8 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Cdca8 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cdca8 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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