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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
C5a receptor activation pathways
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "C5a receptor activation pathways" in MCE Product Catalog:
Cat. No.: HY-177094
CAS No.: 2489430-53-5
Synonyms: INF056
Target:
Research Areas:
Izicopan (INF056) is a complement factor C5a receptor (C5aR1) antagonist. Izicopan inhibits C5a-induced calcium mobilization with an IC50 of 10-100 nM. Izicopan is applicable for the research of complement-mediated inflammatory responses .
Cat. No.: HY-W130878
CAS No.: 1806-26-4
Research Areas:
4-Octylphenol is a hormone disruptor that has gender-specific effects on male reproductive cells, significantly reducing the mitotic index and the number of spermatogonia. 4-Octylphenol can cause inflammatory damage to fish gills by activating the complement system through the C3a/C3aR axis and the C5a/C5aR1 axis, this leads to complement activation and causes immune suppression due to the imbalance between Th1/Th2 cells and regulatory T cells (Treg)/Th17 cells, as well as inflammatory damage via the Toll-like receptor 7 (Toll-like Receptor (TLR))/IκBα/NF-κB pathway .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
