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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
CRM1-IN-1
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "CRM1-IN-1" in MCE Product Catalog:
Cat. No.: HY-155972
CAS No.: 3032506-80-9
CRM1-IN-1 (Compound KL1) is a noncovalent CRM1 inhibitor. CRM1-IN-1 induces nuclear CRM1 degradation (IC50: 0.27 μM). CRM1-IN-1 inhibits CRM1-mediated nuclear export and cell proliferation, and triggers apoptosis in colorectal cancer cells .
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Target:
Leptomycin B (CI 940; LMB) is a potent inhibitor of the nuclear export of proteins. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue. Leptomycin B is a potent antifungal antibiotic blocking the eukaryotic cell cycle .
Synonyms: CBS9106; SL-801
CBS9106 (SL-801) is a reversible oral CRM1 inhibitor with CRM1 degrading and antitumor activities. CBS9106, inhibits CRM1-dependent nuclear export, causing arrest of the cell cycle and inducing apoptosis in a time- and dose-dependent manner for a broad spectrum of cancer cells .
Cat. No.: HY-N6795
CAS No.: 87081-36-5
Category:
Infection Microorganisms Antibiotics Disease Research Antibacterial Disease Research Fields Other Antibiotics
Target:
Cat. No.: HY-17536A
CAS No.: 1421923-86-5
Synonyms: (E)-KPT-330
(E)-Selinexor ((E)-KPT-330) is the E-isomer of Selinexor (HY-17536). Selinexor is the selective, orally active CRM1 inhibitor .
Cat. No.: HY-146384
CAS No.: 2986647-41-8
Target:
Research Areas:
CRM1 degrader 1 is a CRM1 degrader. CRM1 degrader 1 induces mitochondrial pathway-mediated apoptosis. CRM1 degrader 1 dose-dependently reduces CRM1 protein levels via the ubiquitin-proteasome pathway, promotes nuclear accumulation of p53, and regulates Bcl-2 family proteins and caspase activation. CRM1 degrader 1 is applicable to gastric cancer-related research .
Cat. No.: HY-155972A
CAS No.: 3032506-81-0
CRM1-IN-2 (Compound KL2) is a noncovalent CRM1 inhibitor. CRM1-IN-2 localizes CRM1 in the nuclear periphery, depletes nuclear CRM1, and inhibits CRM1-mediated nuclear export. CRM1-IN-2 inhibits growth of colorectal cancer cells, and induces apoptosis .
Cat. No.: HY-16909R
CAS No.: 87081-35-4
Synonyms: CI 940 (Standard); LMB (Standard)
Target:
Leptomycin B (Standard) is the analytical standard of Leptomycin B (HY-16909). This product is intended for research and analytical applications. Leptomycin B (CI 940; LMB) is a potent inhibitor of the nuclear export of proteins. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue. Leptomycin B is a potent antifungal antibiotic blocKing the eukaryotic cell cycle .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
